Maximizing the Electromagnetic and Chemical Resonances of Surface-Enhanced Raman Scattering for Nucleic Acids

ACS Nano ◽  
2014 ◽  
Vol 8 (8) ◽  
pp. 8383-8391 ◽  
Author(s):  
Lindsay M. Freeman ◽  
Lin Pang ◽  
Yeshaiahu Fainman
2018 ◽  
Vol 47 (13) ◽  
pp. 4909-4923 ◽  
Author(s):  
Eduardo Garcia-Rico ◽  
Ramon A. Alvarez-Puebla ◽  
Luca Guerrini

In this tutorial review, we summarize and discuss the most recent cutting-edge research in the field of direct surface-enhanced Raman scattering (SERS) analysis of nucleic acids.


2016 ◽  
Vol 4 (10) ◽  
pp. 1757-1769 ◽  
Author(s):  
Jie Chao ◽  
Wenfang Cao ◽  
Shao Su ◽  
Lixing Weng ◽  
Shiping Song ◽  
...  

Nanostructure-based SERS platforms have been developed for nucleic acid and protein detection ranging from label-free, labeled and multiplex analyses.


2011 ◽  
Vol 25 (1) ◽  
pp. 33-43 ◽  
Author(s):  
Cristina M. Muntean ◽  
Nicolae Leopold ◽  
Adela Halmagyi ◽  
Sergiu Valimareanu

Ultrasensitive detection of nucleic acids is demonstrated through exploiting the effect of surface-enhanced Raman scattering (SERS). In this work the SERS spectra of eight genomic DNAs from leaves of apple trees grown in the field (Malus domesticaBorkh., Fam.Rosaceae, cultivars. Florina, Idared, Rebra, Goldrush, Romus 3, Romus 4 and the rootstocks M9 and M26) have been analyzed in the wavenumber range 200–1800 cm–1. SERS signatures, spectroscopic band assignments and structural interpretations of these plant genomic DNAs are reported. SERS spectra of nucleic acids are compared here with caution, because these signals are time-dependent and are strongly influenced by DNA amount in the measured sample volume. Similarities of the SERS spectra of genomic DNAs extracted from apple leaves of Goldrush, Rebra and Florina cultivars, respectively, have been detected. Besides, the SERS spectra, corresponding to DNA from M9, Romus 4 and M26, leaves, respectively, show similar features and well resolved bands. Based on this work, specific plant DNA-ligand interactions or DNA structural changes induced by plant stress conditions associated with their natural environment, might be further investigated using surface-enhanced Raman spectroscopy.


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