pH-Responsive Assembly of Gold Nanoparticles and “Spatiotemporally Concerted” Drug Release for Synergistic Cancer Therapy

ACS Nano ◽  
2013 ◽  
Vol 7 (4) ◽  
pp. 3388-3402 ◽  
Author(s):  
Jutaek Nam ◽  
Wan-Geun La ◽  
Sekyu Hwang ◽  
Yeong Su Ha ◽  
Nokyoung Park ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Therapy ◽  
Drug Release ◽  
Ph Responsive

Mitochondrial alkaline pH-responsive drug release mediated by Celastrol loaded glycolipid-like micelles for cancer therapy

Biomaterials ◽  
2018 ◽  
Vol 154 ◽  
pp. 169-181 ◽  
Author(s):  
Yanan Tan ◽  
Yun Zhu ◽  
Yue Zhao ◽  
Lijuan Wen ◽  
Tingting Meng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Alkaline Ph ◽  
Ph Responsive

A pH-responsive prodrug for real-time drug release monitoring and targeted cancer therapy

2014 ◽  
Vol 50 (80) ◽  
pp. 11852-11855 ◽  
Author(s):  
Shi-Ying Li ◽  
Li-Han Liu ◽  
Hui-Zhen Jia ◽  
Wen-Xiu Qiu ◽  
Lei Rong ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Real Time ◽  
Targeted Cancer Therapy ◽  
Ph Responsive

A pH-responsive AIE nanoprobe as a drug delivery system for bioimaging and cancer therapy

2015 ◽  
Vol 3 (37) ◽  
pp. 7401-7407 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu ◽  
Shihua Dong ◽  
Junjie Xiong ◽  
Zongliang Du ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cellular Imaging ◽  
Ph Responsive ◽  
Triggered Drug Release

A multifunctional drug delivery system with AIE character was designed and constructed for simultaneous cellular imaging and pH-triggered drug release.

scholarly journals Core–shell structured nanospheres for photothermal ablation and pH-triggered drug delivery toward synergistic cancer therapy

RSC Advances ◽  
2017 ◽  
Vol 7 (43) ◽  
pp. 26640-26649 ◽  
Author(s):  
Tian Zhong ◽  
Jia Fu ◽  
Ran Huang ◽  
Lianjiang Tan
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Core Shell ◽  
Ph Responsive ◽  
Photothermal Conversion ◽  
Photothermal Ablation

Core–shell CuS(DOX)@CS nanospheres with pH-responsive drug release ability and photothermal conversion properties are synthesized for synergistic cancer therapy.

Fe3O4@carbon@zeolitic imidazolate framework-8 nanoparticles as multifunctional pH-responsive drug delivery vehicles for tumor therapy in vivo

2015 ◽  
Vol 3 (46) ◽  
pp. 9033-9042 ◽  
Author(s):  
Mengni He ◽  
Jiajia Zhou ◽  
Jian Chen ◽  
Fangcai Zheng ◽  
Dongdong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Tumor Therapy ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Zeolitic Imidazolate Framework ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Controlled drug release is a promising approach for cancer therapy due to its merits of reduced systemic toxicity and enhanced antitumor efficacy.

Chitosan-Coated Vitis viniferaL Mediated Gold Nanoparticles for Controlled Released of Anticancer Drug Doxorubicin

2017 ◽  
Vol 7 (03) ◽  
Author(s):  
Pradipta Das ◽  
Subash Das ◽  
Niranjan Rout ◽  
Umesh Kumar Parida
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Drug Release ◽  
Breast Cancer Treatment ◽  
Release Profile ◽  
Ph Responsive ◽  
Drug Release Profile ◽  
Uv Visible ◽  
Controlled Released

In this study, we developed encapsulating doxorubicin (DOX) drug loaded CS coated Vitis viniferaL mediated gold nanoparticles (V-AuNPs) [DOX loaded CS coated-V-AuNPs]. V-AuNPs were characterized by UV-Visible spectrophotometer, FTIR, XRD, TEM. The DOX-loaded CS coated-V-AuNPs was evaluated by particle size, surface charge, entrapment efficacy, and effect of pH in drug release profile. Additionally, drug entrapment efficacy (EE) was up to 56%; CS-DOX- V-AuNPs showed a pH-responsive drug release in vitro. The DOX release was nearly 84% at pH 5.4 and 67% at pH 7.4.The current work proves the potential of pharmacology that involves a fusion of advanced techniques from nanoscience to develop the biology and used in the fields of drug delivery, Bio Sensor Manufacturing, Medical therapy and the development of DOX-loaded CS coated-V-AuNPs nanoparticle for sustained, controlled release and may be useful for breast cancer treatment.

Block copolymer [(l-GluA-5-BE)-b-(l-AspA-4-BE)]-based nanoflower capsules with thermosensitive morphology and pH-responsive drug release for cancer therapy

2020 ◽  
Vol 8 (40) ◽  
pp. 9258-9268
Author(s):  
Chander Amgoth ◽  
Shuai Chen ◽  
Tirupathi Malavath ◽  
Guping Tang
Keyword(s):  
Amino Acid ◽  
Block Copolymer ◽  
Cancer Therapy ◽  
Drug Release ◽  
Glutamic Acid ◽  
Aspartic Acid ◽  
Benzyl Ester ◽  
Ph Responsive

Herein, the synthesis of an amino-acid-based di-block copolymer (di-BCP) in-between an l-glutamic acid-5-benzyl ester and L-aspartic acid-4-benzyl ester [(l-GluA-5-BE)-b-(l-AspA-4-BE)] has been reported.

In Vitro Drug Release and Biocatalysis from pH-Responsive Gold Nanoparticles Synthesized Using Doxycycline

Langmuir ◽  
2019 ◽  
Vol 35 (49) ◽  
pp. 16266-16274 ◽  
Author(s):  
Syed Akif Raza Kazmi ◽  
Muhammad Zahid Qureshi ◽  
Shaukat Ali ◽  
Jean-Francois Masson
Keyword(s):  
Gold Nanoparticles ◽  
Drug Release ◽  
Ph Responsive ◽  
In Vitro Drug Release

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

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