Cooperative Organization in Iron Oxide Multi-Core Nanoparticles Potentiates Their Efficiency as Heating Mediators and MRI Contrast Agents

ACS Nano ◽  
2012 ◽  
Vol 6 (12) ◽  
pp. 10935-10949 ◽  
Author(s):  
Lénaic Lartigue ◽  
Pierre Hugounenq ◽  
Damien Alloyeau ◽  
Sarah P. Clarke ◽  
Michael Lévy ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Cooperative Organization ◽  
Core Nanoparticles

One-Step Synthesis of Single-Stranded DNA-Bridged Iron Oxide Supraparticles as MRI Contrast Agents

Nano Letters ◽  
2021 ◽  
Vol 21 (7) ◽  
pp. 2793-2799
Author(s):  
Jingfang Zhang ◽  
Zhenghan Di ◽  
Husheng Yan ◽  
Yuliang Zhao ◽  
Lele Li
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Single Stranded Dna ◽  
Mri Contrast ◽  
One Step

Comparison of commercial iron oxide-based MRI contrast agents with synthesized high-performance MPI tracers

2013 ◽  
Vol 58 (6) ◽  
Author(s):  
Kerstin Lüdtke-Buzug ◽  
Julian Haegele ◽  
Sven Biederer ◽  
Timo F. Sattel ◽  
Marlitt Erbe ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
High Performance ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Commercial Iron

Synthesis of Iron Oxide Nanoparticles Used as MRI Contrast Agents: A Parametric Study

1999 ◽  
Vol 212 (2) ◽  
pp. 474-482 ◽  
Author(s):  
Lucia Babes ◽  
Benoı̂t Denizot ◽  
Gisèle Tanguy ◽  
Jean Jacques Le Jeune ◽  
Pierre Jallet
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Parametric Study ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Mri Contrast

scholarly journals Digital Simulation Assessments of the Sensitivity of Quantitative MRI for Detection of an Iron Oxide Nanoparticle Brain MRI Contrast Agent

2021 ◽  
Author(s):  
Joong Kim ◽  
Wen-Tung Wang ◽  
Andrew Knutsen ◽  
David Brody
Keyword(s):  
Iron Oxide ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Digital Simulation ◽  
Brain Mri ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Simulation Approach ◽  
Mri Contrast ◽  
Mr Relaxation

Abstract There have been substantial efforts to develop targeted exogenous MRI contrast agents to assess specific brain pathologies. In parallel with other efforts, it is important to assess the sensitivity of candidate MRI methods for detection of contrast agents. Here, we propose a digital simulation approach, which includes MR relaxation (R1 and R2) mapping and image co-registration. We simulated the effects of 3 nm iron oxide nanoparticles (IONPs) as a model contrast agent. Two independent relaxation maps acquired from the brain of the same subject were co-registered. The baseline subtraction between the two relaxation maps showed good agreement, demonstrating the high reproducibility of the method. Next, the second relaxation map was digitally altered (“seeded”) to simulate additional MR relaxation values corresponding to several concentrations of 3 nm IONPs in various locations. The maps of absolute differences between the first relaxation map and the digitally altered second relaxation maps were assessed for conspicuity. Results based on living mouse and human brains scanned at 9.4 T and 3.0 T respectively both indicated reliable conspicuity for signal equivalent to 0.06 mM IONP or higher. Overall, the digital simulation approach is a useful method to improve the development of MRI contrast agents and accompanying MRI methodologies.

scholarly journals CARS microscopy for the visualization of micrometer-sized iron oxide MRI contrast agents in living cells

2011 ◽  
Vol 2 (9) ◽  
pp. 2470 ◽  
Author(s):  
Gianluca Rago ◽  
Carolin M. Langer ◽  
Christian Brackman ◽  
James P.R. Day ◽  
Katrin F. Domke ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Living Cells ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Cars Microscopy

scholarly journals Iron oxide nanoparticles stabilized with dendritic polyglycerols as selective MRI contrast agents

Nanoscale ◽  
2014 ◽  
Vol 6 (16) ◽  
pp. 9646-9654 ◽  
Author(s):  
Daniel Nordmeyer ◽  
Patrick Stumpf ◽  
Dominic Gröger ◽  
Andreas Hofmann ◽  
Sven Enders ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast

Superparamagnetic iron oxide nanoparticles with a dendritic polyglycerol (dPG) sulfate strongly bind to L- and P-selectin. Shielding of leukocytes reduces cell extravasation and binding to endothelial cells indicate inflammation specificity and thus, applicability as selective MRI contrast agent.

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