Origin of Enhanced Stem Cell Growth and Differentiation on Graphene and Graphene Oxide

ACS Nano ◽  
2011 ◽  
Vol 5 (9) ◽  
pp. 7334-7341 ◽  
Author(s):  
Wong Cheng Lee ◽  
Candy Haley Y. X. Lim ◽  
Hui Shi ◽  
Lena A. L. Tang ◽  
Yu Wang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Stem Cell ◽  
Cell Growth ◽  
Cell Growth And Differentiation

scholarly journals A Mini Review Focused on the Recent Applications of Graphene Oxide in Stem Cell Growth and Differentiation

2018 ◽  
Author(s):  
Alexander Halim ◽  
Qing Luo ◽  
Yang Ju ◽  
Guanbin Song
Keyword(s):  
Stem Cells ◽  
Graphene Oxide ◽  
Stem Cell ◽  
Cell Growth ◽  
Disease Modeling ◽  
Biological Effects ◽  
Stem Cell Differentiation ◽  
Differentiation Potential ◽  
The World ◽  
Cell Growth And Differentiation

Stem cells are undifferentiated cells which can give rise to any types of cells in our body. Hence, they have been utilized for various applications such as drug testing and disease modeling. However, for the successful of those applications, the survival and differentiation of stem cells into specialized lineages should be well controlled. Growth factors and chemical agents are the most common signals to promote the proliferation and differentiation of stem cells. However, those approaches holds several drawbacks such as the negative side effects, degradation or denaturation, and expensive. To address such limitations, nanomaterials have been recently used as a better approach for controlling stem cells behaviors. Graphene oxide is the derivative of graphene, the first 2D materials in the world. Recently, due to its extraordinary properties and great biological effects on stem cells, many scientists around the world have utilized graphene oxide to enhance the differentiation potential of stem cells. In this mini review, we highlight the key advances about the effects of graphene oxide on controlling stem cell growth and various types of stem cell differentiation. We also discuss the possible molecular mechanisms of graphene oxide in controlling stem cell growth and differentiation.

scholarly journals A Mini Review Focused on the Recent Applications of Graphene Oxide in Stem Cell Growth and Differentiation

Nanomaterials ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 736 ◽  
Author(s):  
Alexander Halim ◽  
Qing Luo ◽  
Yang Ju ◽  
Guanbin Song
Keyword(s):  
Stem Cells ◽  
Graphene Oxide ◽  
Stem Cell ◽  
Cell Growth ◽  
Disease Modeling ◽  
Biological Effects ◽  
Stem Cell Differentiation ◽  
Differentiation Potential ◽  
The World ◽  
Cell Growth And Differentiation

Stem cells are undifferentiated cells that can give rise to any types of cells in our body. Hence, they have been utilized for various applications, such as drug testing and disease modeling. However, for the successful of those applications, the survival and differentiation of stem cells into specialized lineages should be well controlled. Growth factors and chemical agents are the most common signals to promote the proliferation and differentiation of stem cells. However, those approaches holds several drawbacks such as the negative side effects, degradation or denaturation, and expensive. To address such limitations, nanomaterials have been recently used as a better approach for controlling stem cells behaviors. Graphene oxide is the derivative of graphene, the first two-dimensional (2D) materials in the world. Recently, due to its extraordinary properties and great biological effects on stem cells, many scientists around the world have utilized graphene oxide to enhance the differentiation potential of stem cells. In this mini review, we highlight the key advances about the effects of graphene oxide on controlling stem cell growth and various types of stem cell differentiation. We also discuss the possible molecular mechanisms of graphene oxide in controlling stem cell growth and differentiation.

p21 is a critical suppressor of mesenchymal stem cell growth and differentiation after ionizing radiation

2008 ◽  
Vol 207 (3) ◽  
pp. S63
Author(s):  
Marc A. Soares ◽  
John G. Fernandez ◽  
Björn H. Schönmeyr ◽  
Nicholas W. Clavin ◽  
Babak J. Mehrara
Keyword(s):  
Stem Cell ◽  
Cell Growth ◽  
Mesenchymal Stem Cell ◽  
Ionizing Radiation ◽  
Cell Growth And Differentiation

High Content Analysis of Human Embryonic Stem Cell Growth and Differentiation

2007 ◽  
pp. 205-224 ◽  
Author(s):  
Paul J. Sammak ◽  
Vivek Abraham ◽  
Richik Ghosh ◽  
Jeff Haskins ◽  
Esther Jane ◽  
...  
Keyword(s):  
Content Analysis ◽  
Stem Cell ◽  
Cell Growth ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Cell Growth And Differentiation ◽  
High Content Analysis

scholarly journals Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals

2016 ◽  
Vol 11 (1) ◽  
pp. 45-61 ◽  
Author(s):  
Shahab A Shaffiey ◽  
Hongpeng Jia ◽  
Timothy Keane ◽  
Cait Costello ◽  
Deena Wasserman ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Growth ◽  
Intestinal Stem Cell ◽  
Tubular Scaffold ◽  
Cell Growth And Differentiation ◽  
Large Animals

The Influence of Metalized Graphene Oxide/Reduced Graphene Oxide and Sulfonated Polystyrene on Dental Pulp Stem Cell Differentiation and Protein Adsorption

MRS Advances ◽  
2017 ◽  
Vol 2 (19-20) ◽  
pp. 1059-1070 ◽  
Author(s):  
Rachel Sacks ◽  
Gila Schein ◽  
Rebecca Isseroff ◽  
Vincent Ricotta ◽  
Marcia Simon ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Stem Cell ◽  
Protein Adsorption ◽  
Dental Pulp ◽  
Stem Cell Differentiation ◽  
Sulfonated Polystyrene ◽  
Reduced Graphene ◽  
Human Dental Pulp ◽  
Osteogenic Induction ◽  
Cell Growth And Differentiation

ABSTRACTHuman dental pulp stem cells (DPSCs) can differentiate, showing potential for regenerative medicine. Designing artificial surfaces with properties appropriate for the initiation of extracellular matrix (ECM) adsorption and organization is a critical step in tissue engineering and can greatly impact protein adhesion. Sulfonated polystyrene (SPS), used as a scaffold for tissue development, stimulates protein adsorption due to the increased negative charge of sulfonate.Graphene and graphene oxide (GO) sheets enhance stem cell growth and differentiation because they are soft membranes with “high in-plane” stiffness and have the potential to be transferable and implantable platforms. This project functionalized GO and reduced GO (RGO) with gold or silver nanoparticles, mixing with SPS to investigate their combined impact on DPSC differentiation and protein adsorption, hypothesizing that this combination supplies more charges to better absorb the proteins to the surface and stimulate differentiation.Results indicate that proteins of cells plated on the gold-RGO/SPS surfaces were the most highly adsorbed and most densely packed. Additionally, the cell moduli data indicated that the metal-RGO solutions substantially induced a change in modulus even more than Dexamethasone, a glucocortoid known to enhance this process in DPSCs. This suggests that the metal-RGO solutions may be instrumental in osteogenic induction.

scholarly journals Human neural stem cell growth and differentiation in a gradient-generating microfluidic device

Lab on a Chip ◽  
2005 ◽  
Vol 5 (4) ◽  
pp. 401 ◽  
Author(s):  
Bong Geun Chung ◽  
Lisa A. Flanagan ◽  
Seog Woo Rhee ◽  
Philip H. Schwartz ◽  
Abraham P. Lee ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Growth ◽  
Neural Stem Cell ◽  
Microfluidic Device ◽  
Human Neural Stem Cell ◽  
Cell Growth And Differentiation
Sign in / Sign up

Export Citation Format

Share Document