Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells

ACS Nano ◽  
2011 ◽  
Vol 5 (5) ◽  
pp. 3679-3692 ◽  
Author(s):  
Feng Wang ◽  
Yu-Cai Wang ◽  
Shuang Dou ◽  
Meng-Hua Xiong ◽  
Tian-Meng Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Intracellular Drug Delivery

The Enhancement Effect of Gold Nanoparticles in Drug Delivery and as Biomarkers of Drug-Resistant Cancer Cells

ChemMedChem ◽  
2007 ◽  
Vol 2 (3) ◽  
pp. 374-378 ◽  
Author(s):  
Jingyuan Li ◽  
Xuemei Wang ◽  
Chunxia Wang ◽  
Baoan Chen ◽  
Yongyuan Dai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Enhancement Effect ◽  
Drug Resistant

Chondroitin sulfate coated gold nanoparticles: a new strategy to resolve multidrug resistance and thromboinflammation

2016 ◽  
Vol 52 (5) ◽  
pp. 966-969 ◽  
Author(s):  
Deepanjali Gurav ◽  
Oommen P. Varghese ◽  
Osama A. Hamad ◽  
Bo Nilsson ◽  
Jöns Hilborn ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Multidrug Resistance ◽  
Chondroitin Sulfate ◽  
Cancer Cells ◽  
Chemotherapeutic Drug ◽  
New Strategy

We have developed the first chondroitin sulfate polymer coated gold nanoparticles that can simultaneously overcome mulidrug resistance in cancer cells and suppress thromboinflammation triggered by the chemotherapeutic drug.

Biodegradable multiblock polyurethane micelles with tunable reduction-sensitivity for on-demand intracellular drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (47) ◽  
pp. 24736-24746 ◽  
Author(s):  
Xueling He ◽  
Mingming Ding ◽  
Jiehua Li ◽  
Hong Tan ◽  
Qiang Fu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Tumor Cells ◽  
On Demand ◽  
Intracellular Drug Delivery ◽  
Disulfide Linkages ◽  
Drug Delivery Applications

Biodegradable polyurethanes bearing varied amounts of disulfide linkages in the backbone can rapidly enter tumor cells and efficiently transport the encapsulated payloads into cytosol, resulting in controlled inhibition effects against cancer cells. The nanocarriers are promising candidates for on-demand intracellular drug delivery applications.

Drug Delivery: Bypassing Multidrug Resistance in Cancer Cells with Biodegradable Polymer Capsules (Adv. Mater. 47/2010)

2010 ◽  
Vol 22 (47) ◽  
pp. 5324-5324 ◽  
Author(s):  
Yan Yan ◽  
Christopher J. Ochs ◽  
Georgina K. Such ◽  
Joan K. Heath ◽  
Edouard C. Nice ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Biodegradable Polymer

Freezing-Assisted Intracellular Drug Delivery to Multidrug Resistant Cancer Cells

2009 ◽  
Vol 131 (7) ◽  
Author(s):  
Ka Yaw Teo ◽  
Bumsoo Han
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Plasma Membranes ◽  
Cancer Cell Line ◽  
Multidrug Resistant ◽  
Drug Uptake ◽  
Freezing And Thawing ◽  
Intracellular Space ◽  
Intracellular Drug Delivery ◽  
Model Drug

The efficacy of chemotherapy is significantly impaired by the multidrug resistance (MDR) of cancer cells. The mechanism of MDR is associated with the overexpression of certain adenosine triphosphate-binding cassette protein transporters in plasma membranes, which actively pump out cytotoxic drugs from the intracellular space. In this study, we tested a hypothesis that freezing and thawing (F/T) may enhance intracellular drug delivery to MDR cancer cells via F/T-induced denaturation of MDR-associated proteins and/or membrane permeabilization. After a human MDR cancer cell line (NCI/ADR-RES) was exposed to several F/T conditions, its cellular drug uptake was quantified by a fluorescent calcein assay using calcein as a model drug. After F/T to −20°C, the intracellular uptake of calcein increased by 70.1% (n=5, P=0.0004). It further increased to 118% as NCI/ADR-RES cells were frozen/thawed to −40°C (n=3, P=0.009). These results support the hypothesis, and possible mechanisms of F/T-enhanced intracellular drug delivery were proposed and discussed.

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