Mesoporous Biocompatible and Acid-Degradable Magnetic Colloidal Nanocrystal Clusters with Sustainable Stability and High Hydrophobic Drug Loading Capacity

ACS Nano ◽  
2011 ◽  
Vol 5 (2) ◽  
pp. 1428-1435 ◽  
Author(s):  
Bin Luo ◽  
Shuai Xu ◽  
An Luo ◽  
Wen-Rui Wang ◽  
Shi-Long Wang ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
Hydrophobic Drug

Role of zein incorporation on hydrophobic drug-loading capacity and colloidal stability of phospholipid nanoparticles

2018 ◽  
Vol 171 ◽  
pp. 514-521 ◽  
Author(s):  
Soon-Seok Hong ◽  
Raj Kumar Thapa ◽  
Jin-Hee Kim ◽  
Soo-Yeon Kim ◽  
Jong Oh Kim ◽  
...  
Keyword(s):  
Colloidal Stability ◽  
Drug Loading ◽  
Loading Capacity ◽  
Hydrophobic Drug ◽  
Phospholipid Nanoparticles

Design of dual-responsive nanocarries with high drug loading capacity based on hollow mesoporous organosilica nanoparticles

2019 ◽  
Vol 233 ◽  
pp. 230-235 ◽  
Author(s):  
Li-li Lu ◽  
Wen-ya Xiong ◽  
Jun-bin Ma ◽  
Tian-fang Gao ◽  
Si-yuan Peng ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Dual Responsive ◽  
Mesoporous Organosilica ◽  
High Drug Loading

scholarly journals Exploring the drug loading mechanism of photoresponsive inorganic nanocarriers through molecular dynamics simulations

Nanoscale ◽  
2021 ◽  
Author(s):  
Stefano Motta ◽  
Paulo Siani ◽  
Andrea Levy ◽  
Cristiana Di Valentin
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Combine Therapy ◽  
Drug Loading ◽  
Drug Carriers ◽  
Inorganic Nanoparticles ◽  
Loading Capacity ◽  
Physical Stimuli ◽  
Dynamics Simulations

Inorganic nanoparticles are gaining increasing attention as drug carriers because they respond to external physical stimuli, allowing to combine therapy with diagnosis. Their drawback is a low drug loading capacity,...

scholarly journals On the Drug-Loading Capacity of Pectin Powder for Direct Compression

2012 ◽  
Vol 13 (2) ◽  
pp. 601-604
Author(s):  
Ingunn Tho ◽  
Katharina Picker-Freyer ◽  
Linda Salbu ◽  
Annette Bauer-Brandl
Keyword(s):  
Drug Loading ◽  
Direct Compression ◽  
Loading Capacity

scholarly journals Cancer Nanomedicines Stabilized by π-π Stacking between Heterodimeric Prodrugs Enable Exceptionally High Drug Loading Capacity and Safer Delivery of Drug Combinations

Theranostics ◽  
2017 ◽  
Vol 7 (15) ◽  
pp. 3638-3652 ◽  
Author(s):  
Hangxiang Wang ◽  
Jianmei Chen ◽  
Chang Xu ◽  
Linlin Shi ◽  
Munire Tayier ◽  
...  
Keyword(s):  
Drug Loading ◽  
Drug Combinations ◽  
Loading Capacity ◽  
High Drug ◽  
Π Stacking ◽  
High Drug Loading

scholarly journals Synthesis of pH-Sensitive and Self-Fluorescent Polymeric Micelles Derived From Rosin and Vegetable Oils via ATRP

2021 ◽  
Vol 9 ◽  
Author(s):  
Juan Yu ◽  
Chaoqun Xu ◽  
Chuanwei Lu ◽  
Qian Liu ◽  
Jifu Wang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Vegetable Oils ◽  
Renewable Resources ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Dehydroabietic Acid ◽  
Great Promise ◽  
Loading Capacity ◽  
Carboxylic Groups ◽  
Ph Dependent

Preparation and application of sustainable polymers derived from renewable resources are of great significance. The aim of this study is to synthesize a kind of sustainable polymeric micelles from rosin and vegetable oils via atom transfer radical polymerization (ATRP) and to investigate the doxorubicin delivery properties of these micelles. Dehydroabietic acid–based poly lauryl methacrylate (DA-PLMA) with narrow PDI of 1.13 was prepared in a well-controlled process using rosin as an ATRP initiator. Thereafter, carboxylic groups were introduced to form poly methacrylic acid (PMAA) moieties in DA-PLMA polymer via acid hydrolysis. The resulted DA-PLMA-PMAA could self-assemble in water to form pH-dependent polymeric micelles with a diameter of ∼65 nm and PDI as low as 0.105. Owing to the existence of rosin, DA-PLMA-PMAA micelles also showed self-fluorescence properties. In addition, Dox-loaded micelles were prepared in aqueous solution with the drug-loading capacity as high as 16.0% and showed sustained-release characteristics. These results demonstrate great promise for designing polymeric micellar from rosin and vegetable oils.

scholarly journals Synthesis and Characterization of Stearic Acid-Beclomethasone Dipropionate Conjugates with the Potential for Improving Loading Capacity in Lipid-based Nanoparticles

2021 ◽  
Author(s):  
Shishuai Dang ◽  
Zhengwei Huang ◽  
Ying Huang ◽  
Xin Pan ◽  
Chuanbin Wu
Keyword(s):  
Drug Delivery ◽  
Stearic Acid ◽  
Beclomethasone Dipropionate ◽  
Drug Loading ◽  
Pulmonary Delivery ◽  
Dynamics Simulation ◽  
Loading Capacity ◽  
Technology Platform ◽  
New Type ◽  
Model Drug

<p>Lipid-based nanoparticles (LBNs) are a new type of nanoparticulate drug delivery system, which have been gradually shown broad prospects in pulmonary drug delivery systems. However, the main disadvantage of these LBNs for inhalable drugs with limited lipophilicity is the low encapsulation capacity. Herein, this study anticipates establishing a technology platform to improve the loading capacity of low lipophilicity drugs in LBNs, for the therapy of lung diseases. A proof-of-concept was carried out using Beclomethasone dipropionate (BDP) as a model drug. BDP was conjugated with stearic acid (SA), a kind of the lipid matrix for LBN. The conjugate was characterized and the interactions between the conjugate and SA were investigated by molecular dynamics simulation. It is expected that the drug loading capacity of weak-lipophilic drugs in LBN can be increased by establishing the technology platform, and the application of LBNs in pulmonary delivery can be broadened.</p>

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