scholarly journals The Nanoscale Geometrical Maturation of Focal Adhesions Controls Stem Cell Differentiation and Mechanotransduction

Nano Letters ◽  
2014 ◽  
Vol 14 (7) ◽  
pp. 3945-3952 ◽  
Author(s):  
Julien E. Gautrot ◽  
Jenny Malmström ◽  
Maria Sundh ◽  
Coert Margadant ◽  
Arnoud Sonnenberg ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Focal Adhesions ◽  
Stem Cell Differentiation

Micro-Engineered Sythetical Extrocellular Metrix for Stem Cell Differentiation Study

2010 ◽  
Author(s):  
Jianping Fu
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Cell Morphology ◽  
Focal Adhesions ◽  
Stem Cell Differentiation ◽  
Material Surface ◽  
Single Cell Level ◽  
Cell Level ◽  
Substrate Rigidity ◽  
Non Destructive

We report the use of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. We demonstrate that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility, and stem cell differentiation. Furthermore, these micropost arrays reveal that changes in cytoskeletal contractility can precede stem cell differentiation and be utilized as a non-destructive predictor for fate decisions at the single cell level.

Mechanical Regulation of Stem Cell Differentiation on Geometrically Modulated Elastomeric Substrates

2010 ◽  
Author(s):  
Jianping Fu
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Cell Morphology ◽  
Focal Adhesions ◽  
Stem Cell Differentiation ◽  
Material Surface ◽  
Single Cell Level ◽  
Cell Level ◽  
Substrate Rigidity ◽  
Non Destructive

We report the use of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. We demonstrate that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility, and stem cell differentiation. Furthermore, these micropost arrays reveal that changes in cytoskeletal contractility can precede stem cell differentiation and be utilized as a non-destructive predictor for fate decisions at the single cell level.

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