Preparation of Redox-Sensitive Shell Cross-Linked Nanoparticles for Controlled Release of Bioactive Agents

2012 ◽  
Vol 1 (4) ◽  
pp. 489-493 ◽  
Author(s):  
Guohua Jiang ◽  
Yin Wang ◽  
Rui Zhang ◽  
Rijing Wang ◽  
Xiaohong Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Bioactive Agents

Controlled release and corrosion protection by self-assembled colloidal particles electrodeposited onto magnesium alloys

2015 ◽  
Vol 3 (8) ◽  
pp. 1667-1676 ◽  
Author(s):  
Jiadi Sun ◽  
Ye Zhu ◽  
Long Meng ◽  
Wei Wei ◽  
Yang Li ◽  
...  
Keyword(s):  
Corrosion Resistance ◽  
Magnesium Alloy ◽  
Controlled Release ◽  
Magnesium Alloys ◽  
Corrosion Protection ◽  
Colloidal Particles ◽  
Self Assembled ◽  
Bioactive Agents

Self-assembled nanoparticles loaded with bioactive agents were electrodeposited to provide the magnesium alloy with controlled release and corrosion resistance properties.

scholarly journals Nanoscale and Macroscale Scaffolds with Controlled-Release Polymeric Systems for Dental Craniomaxillofacial Tissue Engineering.

2021 ◽  
Author(s):  
Saeed Ur Rahman ◽  
Malvika Nagrath ◽  
Sasikumar Ponnusamy ◽  
Praveen R. Arany
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Controlled Release ◽  
Cell Biology ◽  
Biological Molecules ◽  
Cellular Behavior ◽  
Polymeric Systems ◽  
Biological Responses ◽  
Bioactive Agents ◽  
Craniofacial Tissue

Tremendous progress in stem cell biology has resulted in a major current focus on effective modalities to promote directed cellular behavior for clinical therapy. The fundamental principles of tissue engineering are aimed at providing soluble and insoluble biological cues to promote these directed biological responses. Better understanding of extracellular matrix functions is ensuring optimal adhesive substrates to promote cell mobility and a suitable physical niche to direct stem cell responses. Further, appreciation of the roles of matrix constituents as morphogen cues, termed matrikines or matricryptins, are also now being directly exploited in biomaterial design. These insoluble topological cues can be presented at both micro- and nanoscales with specific fabrication techniques. Progress in development and molecular biology has described key roles for a range of biological molecules, such as proteins, lipids, and nucleic acids, to serve as morphogens promoting directed behavior in stem cells. Controlled-release systems involving encapsulation of bioactive agents within polymeric carriers are enabling utilization of soluble cues. Using our efforts at dental craniofacial tissue engineering, this narrative review focuses on outlining specific biomaterial fabrication techniques, such as electrospinning, gas foaming, and 3D printing used in combination with polymeric nano- or microspheres. These avenues are providing unprecedented therapeutic opportunities for precision bioengineering for regenerative applications.

Polyanhydrides for controlled release of bioactive agents

Biomaterials ◽  
1986 ◽  
Vol 7 (5) ◽  
pp. 364-371 ◽  
Author(s):  
K.W. Leong ◽  
J. Kost ◽  
E. Mathiowitz ◽  
R. Langer
Keyword(s):  
Controlled Release ◽  
Bioactive Agents

scholarly journals Polysaccharide κ-Carrageenan as Doping Agent in Conductive Coatings for Electrochemical Controlled Release of Dexamethasone at Therapeutic Doses

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2139 ◽  
Author(s):  
Karla Ramírez Sánchez ◽  
Aura Ledezma-Espinoza ◽  
Andrés Sánchez-Kopper ◽  
Esteban Avendaño-Soto ◽  
Mónica Prado ◽  
...  
Keyword(s):  
Controlled Release ◽  
Electrical Properties ◽  
High Resolution Mass Spectrometry ◽  
Physical Stability ◽  
Doping Agent ◽  
Release Process ◽  
As Doping ◽  
Organic Bioelectronics ◽  
Bioactive Agents ◽  
Therapeutic Doses

Smart conductive materials are developed in regenerative medicine to promote a controlled release profile of charged bioactive agents in the vicinity of implants. The incorporation and the active electrochemical release of the charged compounds into the organic conductive coating is achieved due to its intrinsic electrical properties. The anti-inflammatory drug dexamethasone was added during the polymerization, and its subsequent release at therapeutic doses was reached by electrical stimulation. In this work, a Poly (3,4-ethylenedioxythiophene): κ-carrageenan: dexamethasone film was prepared, and κ-carrageenan was incorporated to keep the electrochemical and physical stability of the electroactive matrix. The presence of κ-carrageenan and dexamethasone in the conductive film was confirmed by µ-Raman spectroscopy and their effect in the topographic was studied using profilometry. The dexamethasone release process was evaluated by cyclic voltammetry and High-Resolution mass spectrometry. In conclusion, κ-carrageenan as a doping agent improves the electrical properties of the conductive layer allowing the release of dexamethasone at therapeutic levels by electrochemical stimulation, providing a stable system to be used in organic bioelectronics systems.

Controlled release of bioactive agents

Biomaterials ◽  
1982 ◽  
Vol 3 (1) ◽  
pp. 59
Author(s):  
N.B. Graham
Keyword(s):  
Controlled Release ◽  
Bioactive Agents

scholarly journals Nanoscale and Macroscale Scaffolds with Controlled-Release Polymeric Systems for Dental Craniomaxillofacial Tissue Engineering.

2021 ◽  
Author(s):  
Saeed Ur Rahman ◽  
Malvika Nagrath ◽  
Sasikumar Ponnusamy ◽  
Praveen R. Arany
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Controlled Release ◽  
Cell Biology ◽  
Biological Molecules ◽  
Cellular Behavior ◽  
Polymeric Systems ◽  
Biological Responses ◽  
Bioactive Agents ◽  
Craniofacial Tissue

Tremendous progress in stem cell biology has resulted in a major current focus on effective modalities to promote directed cellular behavior for clinical therapy. The fundamental principles of tissue engineering are aimed at providing soluble and insoluble biological cues to promote these directed biological responses. Better understanding of extracellular matrix functions is ensuring optimal adhesive substrates to promote cell mobility and a suitable physical niche to direct stem cell responses. Further, appreciation of the roles of matrix constituents as morphogen cues, termed matrikines or matricryptins, are also now being directly exploited in biomaterial design. These insoluble topological cues can be presented at both micro- and nanoscales with specific fabrication techniques. Progress in development and molecular biology has described key roles for a range of biological molecules, such as proteins, lipids, and nucleic acids, to serve as morphogens promoting directed behavior in stem cells. Controlled-release systems involving encapsulation of bioactive agents within polymeric carriers are enabling utilization of soluble cues. Using our efforts at dental craniofacial tissue engineering, this narrative review focuses on outlining specific biomaterial fabrication techniques, such as electrospinning, gas foaming, and 3D printing used in combination with polymeric nano- or microspheres. These avenues are providing unprecedented therapeutic opportunities for precision bioengineering for regenerative applications.

Preparation and Characterization of PP-PVA Blends and Controlled Release System Comprising Bensulfuron-Methyl

2011 ◽  
Vol 399-401 ◽  
pp. 1257-1260 ◽  
Author(s):  
Li Min Tai
Keyword(s):  
Controlled Release ◽  
Scanning Calorimetry ◽  
Release Formulation ◽  
Release System ◽  
Single Screw Extruder ◽  
Neutral Media ◽  
Novel Method ◽  
Controlled Release System ◽  
Bioactive Agents

The matrixes for the controlled release system have been prepared by blending polyvinyl alcohol (PVA) and the reworked granules of recycled polypropylene (PP) with EVA as a compatibilizer on a single screw extruder. The changes of microphase (crystalline) structure and macrophase structure of the PP/PVA blends were investigated by the differential scanning calorimetry (DSC) and scanning electron microscope (SEM). The controlled release formulation (CRF) of Bensulfuron-methyl based on the blends was prepared by means of melt-extrusion, and the release behaviors of bioactive agents were investigated in the different pH buffers with UV spectrophotometer. To a certain extent, the PP/PVA blends showed the components compatibility. The results also showed that there was gradual decrease in the crystallinity of PP with increasing PVA content. The bensulfuron-methyl CRFs exhibited the obviously controlled-release function. The release rate of bensulfuron-methyl was found to be faster in the neutral media than in acidic or basic media. The pesticide CRFs could have an important potential in reducing inefficient use and impact of pesticides in the environment. Moreover, a novel method was provided for recycling and utilizing PP wasters.

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