A mathematical model for predicting controlled release of bioactive agents from composite fiber structures

2007 ◽  
Vol 80A (3) ◽  
pp. 679-686 ◽  
Author(s):  
Meital Zilberman ◽  
Moran Sofer
Keyword(s):  
Mathematical Model ◽  
Controlled Release ◽  
Composite Fiber ◽  
Bioactive Agents

Controlled release and corrosion protection by self-assembled colloidal particles electrodeposited onto magnesium alloys

2015 ◽  
Vol 3 (8) ◽  
pp. 1667-1676 ◽  
Author(s):  
Jiadi Sun ◽  
Ye Zhu ◽  
Long Meng ◽  
Wei Wei ◽  
Yang Li ◽  
...  
Keyword(s):  
Corrosion Resistance ◽  
Magnesium Alloy ◽  
Controlled Release ◽  
Magnesium Alloys ◽  
Corrosion Protection ◽  
Colloidal Particles ◽  
Self Assembled ◽  
Bioactive Agents

Self-assembled nanoparticles loaded with bioactive agents were electrodeposited to provide the magnesium alloy with controlled release and corrosion resistance properties.

Preparation of Redox-Sensitive Shell Cross-Linked Nanoparticles for Controlled Release of Bioactive Agents

2012 ◽  
Vol 1 (4) ◽  
pp. 489-493 ◽  
Author(s):  
Guohua Jiang ◽  
Yin Wang ◽  
Rui Zhang ◽  
Rijing Wang ◽  
Xiaohong Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Bioactive Agents

scholarly journals The development of crosslinked gelatin thin films as controlled release matrices

2021 ◽  
Author(s):  
Alireza Abbasi
Keyword(s):  
Thin Films ◽  
Mathematical Model ◽  
Controlled Release ◽  
Release Kinetics ◽  
Fluorescent Marker ◽  
Force Microscopy ◽  
Standard Glass ◽  
Atomic Force ◽  
Gelatin Films ◽  
Glass Slides

The aim of this thesis was to develop gelatin-based thin films that may be used as matrices for the controlled release of bioactive compounds. There were three objectives to this research: i) develop a method to generate the thin films ii) experimentally quantify the release of a fluorescent marker from these films, and iii) implement a mathematical model to characterize the release of the fluorescent marker. To achieve the first objective, a novel method of developing thin films was implemented where sub-micron thickness films affixed to standard glass slides were crosslinked with genipin, a naturally-occurring fixative. Gel thickness measured using atomic force microscopy (AFM) varied from 350 to 650 nm irrespective of the concentration of genifin added. AFM-based surface roughness decreased with increasing genipin concentration. Release behavior of a fluorescent marker from the thin films demonstrated a strong influence of genipin concentration on release kinetics, with greater genipin leading to slower release. A mathematical model for the water transport into, and fluorescent marker release from, the genipin-crosslinked gelatin films was developed and successfully implemented with both the water ingress (swelling) and marker release being effectively characterized by the model.

scholarly journals The development of crosslinked gelatin thin films as controlled release matrices

2021 ◽  
Author(s):  
Alireza Abbasi
Keyword(s):  
Thin Films ◽  
Mathematical Model ◽  
Controlled Release ◽  
Release Kinetics ◽  
Fluorescent Marker ◽  
Force Microscopy ◽  
Standard Glass ◽  
Atomic Force ◽  
Gelatin Films ◽  
Glass Slides

The aim of this thesis was to develop gelatin-based thin films that may be used as matrices for the controlled release of bioactive compounds. There were three objectives to this research: i) develop a method to generate the thin films ii) experimentally quantify the release of a fluorescent marker from these films, and iii) implement a mathematical model to characterize the release of the fluorescent marker. To achieve the first objective, a novel method of developing thin films was implemented where sub-micron thickness films affixed to standard glass slides were crosslinked with genipin, a naturally-occurring fixative. Gel thickness measured using atomic force microscopy (AFM) varied from 350 to 650 nm irrespective of the concentration of genifin added. AFM-based surface roughness decreased with increasing genipin concentration. Release behavior of a fluorescent marker from the thin films demonstrated a strong influence of genipin concentration on release kinetics, with greater genipin leading to slower release. A mathematical model for the water transport into, and fluorescent marker release from, the genipin-crosslinked gelatin films was developed and successfully implemented with both the water ingress (swelling) and marker release being effectively characterized by the model.

scholarly journals Nanoscale and Macroscale Scaffolds with Controlled-Release Polymeric Systems for Dental Craniomaxillofacial Tissue Engineering.

2021 ◽  
Author(s):  
Saeed Ur Rahman ◽  
Malvika Nagrath ◽  
Sasikumar Ponnusamy ◽  
Praveen R. Arany
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Controlled Release ◽  
Cell Biology ◽  
Biological Molecules ◽  
Cellular Behavior ◽  
Polymeric Systems ◽  
Biological Responses ◽  
Bioactive Agents ◽  
Craniofacial Tissue

Tremendous progress in stem cell biology has resulted in a major current focus on effective modalities to promote directed cellular behavior for clinical therapy. The fundamental principles of tissue engineering are aimed at providing soluble and insoluble biological cues to promote these directed biological responses. Better understanding of extracellular matrix functions is ensuring optimal adhesive substrates to promote cell mobility and a suitable physical niche to direct stem cell responses. Further, appreciation of the roles of matrix constituents as morphogen cues, termed matrikines or matricryptins, are also now being directly exploited in biomaterial design. These insoluble topological cues can be presented at both micro- and nanoscales with specific fabrication techniques. Progress in development and molecular biology has described key roles for a range of biological molecules, such as proteins, lipids, and nucleic acids, to serve as morphogens promoting directed behavior in stem cells. Controlled-release systems involving encapsulation of bioactive agents within polymeric carriers are enabling utilization of soluble cues. Using our efforts at dental craniofacial tissue engineering, this narrative review focuses on outlining specific biomaterial fabrication techniques, such as electrospinning, gas foaming, and 3D printing used in combination with polymeric nano- or microspheres. These avenues are providing unprecedented therapeutic opportunities for precision bioengineering for regenerative applications.

A mathematical model for pulsatile release: Controlled release of rhodamine B from UV-crosslinked thermoresponsive thin films

2012 ◽  
Vol 427 (2) ◽  
pp. 320-327 ◽  
Author(s):  
Rongbing Yang ◽  
Tuoi Vo T. N. ◽  
Alexander V. Gorelov ◽  
Fawaz Aldabbagh ◽  
William M. Carroll ◽  
...  
Keyword(s):  
Thin Films ◽  
Mathematical Model ◽  
Controlled Release ◽  
Rhodamine B ◽  
Pulsatile Release
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