scholarly journals Biological Barriers to Therapy with Antisense and siRNA Oligonucleotides

2009 ◽  
Vol 6 (3) ◽  
pp. 686-695 ◽  
Author(s):  
R. Juliano ◽  
J. Bauman ◽  
H. Kang ◽  
X. Ming
Keyword(s):  
Biological Barriers ◽  
Barriers To Therapy

Review of Biological Barriers in Behavioral Medicine.

1991 ◽  
Vol 36 (7) ◽  
pp. 641-641
Author(s):  
No authorship indicated
Keyword(s):  
Behavioral Medicine ◽  
Biological Barriers

The Role of Carrier Geometry in Overcoming Biological Barriers to Drug Delivery

2016 ◽  
Vol 22 (9) ◽  
pp. 1259-1273 ◽  
Author(s):  
Carolyn Jordan ◽  
Vladimir V. Shuvaev ◽  
Mark Bailey ◽  
Vladimir R. Muzykantov ◽  
Thomas D. Dziubla
Keyword(s):  
Drug Delivery ◽  
Biological Barriers

Evaluation of the Biological Fate and the Transport Through Biological Barriers of Nanosilver in Mice

2013 ◽  
Vol 19 (37) ◽  
pp. 6691-6697 ◽  
Author(s):  
Zhe Wang ◽  
Guangbo Qu ◽  
Lina Su ◽  
Lei Wang ◽  
Zuozhi Yang ◽  
...  
Keyword(s):  
Biological Barriers ◽  
Biological Fate

scholarly journals Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 122 ◽  
Author(s):  
Rebekah Omarkhail Elliott ◽  
Mei He
Keyword(s):  
Drug Delivery ◽  
Traffic Control ◽  
Information Transfer ◽  
Cancer Metastasis ◽  
Research Field ◽  
Blood Retinal Barrier ◽  
Biological Barriers ◽  
Diagnostic Role ◽  
Delivery Platform ◽  
Traffic Control System

Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup of nanovesicles called exosomes has been driving the research field to a new regime for understanding cellular communication. This exosome-dominated traffic control system has increased understanding of many diseases, including cancer metastasis, diabetes, and HIV. In addition to the important diagnostic role, exosomes are particularly attractive for drug delivery, due to their distinctive properties in cellular information transfer and uptake. Compared to viral and non-viral synthetic systems, the natural, cell-derived exosomes exhibit intrinsic payload and bioavailability. Most importantly, exosomes easily cross biological barriers, obstacles that continue to challenge other drug delivery nanoparticle systems. Recent emerging studies have shown numerous critical roles of exosomes in many biological barriers, including the blood–brain barrier (BBB), blood–cerebrospinal fluid barrier (BCSFB), blood–lymph barrier (BlyB), blood–air barrier (BAB), stromal barrier (SB), blood–labyrinth barrier (BLaB), blood–retinal barrier (BRB), and placental barrier (PB), which opens exciting new possibilities for using exosomes as the delivery platform. However, the systematic reviews summarizing such discoveries are still limited. This review covers state-of-the-art exosome research on crossing several important biological barriers with a focus on the current, accepted models used to explain the mechanisms of barrier crossing, including tight junctions. The potential to design and engineer exosomes to enhance delivery efficacy, leading to future applications in precision medicine and immunotherapy, is discussed.

“Fishing” nano–bio interactions at the key biological barriers

Nanoscale ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 5954-5964
Author(s):  
Jinyu Rong ◽  
Yuan He ◽  
Juanjuan Tang ◽  
Ruxia Qiao ◽  
Sijie Lin
Keyword(s):  
Environmental Applications ◽  
Biological Barriers

Understanding nano–bio interactions is pivotal to the safe implementation of nanotechnology for both biological and environmental applications.

scholarly journals Reconstituted HDL: Drug Delivery Platform for Overcoming Biological Barriers to Cancer Therapy

2018 ◽  
Vol 9 ◽  
Author(s):  
Sangram Raut ◽  
Linda Mooberry ◽  
Nirupama Sabnis ◽  
Ashwini Garud ◽  
Akpedje Serena Dossou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Biological Barriers ◽  
Delivery Platform
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