scholarly journals Self-Assembling Peptide Amphiphile-Based Nanofiber Gel for Bioresponsive Cisplatin Delivery

2009 ◽  
Vol 6 (3) ◽  
pp. 978-985 ◽  
Author(s):  
Jin-Ki Kim ◽  
Joel Anderson ◽  
Ho-Wook Jun ◽  
Michael A. Repka ◽  
Seongbong Jo
Keyword(s):  
Peptide Amphiphile ◽  
Self Assembling

COMPUTER SIMULATIONS TO INVESTIGATE STABILITY AND STRUCTURAL PROPERTIES OF PEPTIDE AMPHIPHILE NANOFIBERS

2007 ◽  
Vol 06 (03) ◽  
pp. 621-630
Author(s):  
RUO-YU CHEN ◽  
LING-YING WU ◽  
JUN-MIN LIAO ◽  
CHENG-LUNG CHEN
Keyword(s):  
Molecular Dynamics ◽  
Disulfide Bonds ◽  
Md Simulation ◽  
Intermolecular Hydrogen Bond ◽  
Intermolecular Distance ◽  
Peptide Amphiphile ◽  
Hydrogen Bond Interactions ◽  
Self Assembling ◽  
Polar Groups ◽  
The Stability

Molecular mechanics (MM) method followed by molecular dynamics (MD) simulation was carried out to investigate the stability of an aggregate formed by self-assembling of peptide amphiphile (PA) molecules. The MM + MD simulation confirms that the cylindrical shaped aggregate is very stable. The analysis showed that the remarkable stability of the aggregate was partly due to various intermolecular hydrogen-bond interactions between polar groups of PA molecules. The hydrophobic alkyl tails of PA molecules are packed loosely inside the interior of the aggregates. The packing of alkyl tails contribute further stability of the PA aggregate. Our simulations reproduce qualitatively experimental observations and support the fact that PA molecules are self-assembled within closed intermolecular distance to favor the forming of disulfide bonds.

scholarly journals Self-assembling peptide amphiphile promotes plasticity of serotonergic fibers following spinal cord injury

2010 ◽  
Vol 88 (14) ◽  
pp. 3161-3170 ◽  
Author(s):  
Vicki M. Tysseling ◽  
Vibhu Sahni ◽  
Eugene T. Pashuck ◽  
Derin Birch ◽  
Amy Hebert ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Peptide Amphiphile ◽  
Self Assembling ◽  
Cord Injury

Epitope Peptide Amphiphile-Based Nanofiber as an Effective Vaccine for Viral Infectious Diseases

2020 ◽  
Vol 20 (9) ◽  
pp. 5329-5332 ◽  
Author(s):  
Yu-Gyeong Kim ◽  
Yunsu Lee ◽  
Jong-Wha Jung ◽  
Hyo-Eon Jin
Keyword(s):  
Immune Responses ◽  
Enterovirus 71 ◽  
Foot And Mouth Disease ◽  
Effective Vaccine ◽  
Epitope Peptide ◽  
Serum Samples ◽  
Peptide Amphiphile ◽  
Force Microscopy ◽  
Self Assembling ◽  
Atomic Force

Peptide-based vaccines are relatively safe but have weak immune responses even with an adjuvant. In order to overcome the limitations of peptide-based vaccines, we developed peptide amphiphile (PA)-based nanofibers to enhance the immune responses for preventing enterovirus 71 (EV71) infectious disease (i.e., Hand, Foot, and Mouth Disease). PAs are peptides conjugated with fatty acid alkyl chain and able to self-assemble into various structures including high-aspectratio nanofibers. We designed PAs by coupling EV71 virus particle 1 (VP1) epitope peptides and spacer-crosslinker to the N-terminal of long-chain fatty acids (VP1-PA). PAs then self-assembled into nanofibers at physiological pH (pH 7.4). PA nanofibers were characterized by atomic force microscopy (AFM). For the immunization studies, C57BL/6 mice were injected intraperitoneally (i.p.) with recombinant VP1 with adjuvant (alum), VP1 epitope peptide with or without adjuvant, VP1-PA nanofibers with or without adjuvant, and PBS. To assess the immunogenecity of the VP1-PA nanofibers on serum samples from the immunized mice was analyzed by Western blot for the evaluation of VP1-specific IgG. The PA group showed a higher immune response than the peptide group. We expect that self-assembling VP1-PA based nanofibers as an immune stimulator could enhance immune responses effectively against EV71 infection and overcome the limitations of peptide-based vaccine.

Self-assembling peptide amphiphile nanofiber matrices for cell entrapment

2005 ◽  
Vol 1 (4) ◽  
pp. 387-397 ◽  
Author(s):  
Elia Beniash ◽  
Jeffery D. Hartgerink ◽  
Hannah Storrie ◽  
John C. Stendahl ◽  
Samuel I. Stupp
Keyword(s):  
Peptide Amphiphile ◽  
Cell Entrapment ◽  
Self Assembling

scholarly journals Redox modulated hydrogelation of a self-assembling short peptide amphiphile

2012 ◽  
Vol 57 (33) ◽  
pp. 4296-4303 ◽  
Author(s):  
ChangHai Cao ◽  
MeiWen Cao ◽  
HaiMing Fan ◽  
DaoHong Xia ◽  
Hai Xu ◽  
...  
Keyword(s):  
Peptide Amphiphile ◽  
Short Peptide ◽  
Self Assembling

Self-Assembling Peptide Amphiphile Nanofibers as a Scaffold for Dental Stem Cells

2008 ◽  
Vol 14 (12) ◽  
pp. 2051-2058 ◽  
Author(s):  
Kerstin M. Galler ◽  
Adriana Cavender ◽  
Virany Yuwono ◽  
He Dong ◽  
Songtao Shi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Stem Cells ◽  
Peptide Amphiphile ◽  
Self Assembling

scholarly journals Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers

Biopolymers ◽  
2007 ◽  
Vol 88 (2) ◽  
pp. 115-121 ◽  
Author(s):  
Antonella Accardo ◽  
Diego Tesauro ◽  
Gaetano Mangiapia ◽  
Carlo Pedone ◽  
Giancarlo Morelli
Keyword(s):  
Drug Carriers ◽  
Peptide Amphiphile ◽  
Self Assembling

scholarly journals Reversible helical unwinding transition of a self-assembling peptide amphiphile

Soft Matter ◽  
2013 ◽  
Vol 9 (39) ◽  
pp. 9290 ◽  
Author(s):  
Ian W. Hamley ◽  
Ashkan Dehsorkhi ◽  
Valeria Castelletto ◽  
Steve Furzeland ◽  
Derek Atkins ◽  
...  
Keyword(s):  
Peptide Amphiphile ◽  
Self Assembling

Supramolecular Interactions and Morphology of Self-Assembling Peptide Amphiphile Nanostructures

Nano Letters ◽  
2021 ◽  
Author(s):  
M. Hussain Sangji ◽  
Hiroaki Sai ◽  
Stacey M. Chin ◽  
Sieun Ruth Lee ◽  
Ivan R Sasselli ◽  
...  
Keyword(s):  
Supramolecular Interactions ◽  
Peptide Amphiphile ◽  
Self Assembling

scholarly journals Correction to “Supramolecular Interactions and Morphology of Self-Assembling Peptide Amphiphile Nanostructures”

Nano Letters ◽  
2021 ◽  
Author(s):  
M. Hussain Sangji ◽  
Hiroaki Sai ◽  
Stacey M. Chin ◽  
Sieun Ruth Lee ◽  
Ivan R. Sasselli ◽  
...  
Keyword(s):  
Supramolecular Interactions ◽  
Peptide Amphiphile ◽  
Self Assembling
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