scholarly journals Self-assembling peptide amphiphile promotes plasticity of serotonergic fibers following spinal cord injury

2010 ◽  
Vol 88 (14) ◽  
pp. 3161-3170 ◽  
Author(s):  
Vicki M. Tysseling ◽  
Vibhu Sahni ◽  
Eugene T. Pashuck ◽  
Derin Birch ◽  
Amy Hebert ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Peptide Amphiphile ◽  
Self Assembling ◽  
Cord Injury

scholarly journals Investigation on the Motor Recovery Effect of a Self-Assembling Nanofiber in the Spinal Cord Injury Model in Rat

2014 ◽  
Vol 2 (2) ◽  
pp. 41-46 ◽  
Author(s):  
Shima Tavakol ◽  
Hadi Aligholi ◽  
Arezou Eshaghabadi ◽  
Mostafa Modarres Mousavi ◽  
Jafar Ai ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Recovery ◽  
Recovery Effect ◽  
Self Assembling ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury

scholarly journals Comparing natural hydrogels to self-assembling peptides in spinal cord injury treatment: a systematic review

F1000Research ◽  
2022 ◽  
Vol 11 ◽  
pp. 16
Author(s):  
Kurosh Mojtabavi ◽  
Morteza Gholami ◽  
Zahra Ghodsi ◽  
Narges Mahmoodi ◽  
Sina Shool ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Data Extraction ◽  
Included Study ◽  
Cns Injury ◽  
Neuronal Regeneration ◽  
Self Assembling ◽  
Cord Injury ◽  
Injury Treatment

Background: In many cases, central nervous system (CNS) injury is unchanging due to the absence of neuronal regeneration and repair capabilities. In recent years, regenerative medicine, and especially hydrogels, has reached a significant amount of attention for their promising results for the treatment of spinal cord injury (SCI) currently considered permanent. Hydrogels are categorized based on their foundation: synthetic, natural, and combination. The objective of this study was to compare the properties and efficacy of commonly used hydrogels, like collagen, and other natural peptides with synthetic self-assembling peptide hydrogels in the treatment of SCI.  Methods: Articles were searched in PubMed, Scopus, Web of Science, and Embase. All studies from 1985 until January 2020 were included in the primary search. Eligible articles were included based on the following criteria: administering hydrogels (both natural and synthetic) for SCI treatment, solely focusing on spinal cord injury treatment, and published in a peer-reviewed journal. Data on axonal regeneration, revascularization, elasticity, drug delivery efficacy, and porosity were extracted. Results: A total of 24 articles were included for full-text review and data extraction. There was only one experimental study comparing collagen I (natural hydrogel) and polyethylene glycol (PEG) in an in vitro setting. The included study suggested the behavior of cells with PEG is more expectable in the injury site, which makes it a more reliable scaffold for neurites. Conclusions: There is limited research comparing and evaluating both types of natural and self-assembling peptides (SAPs) in the same animal or in vitro study, despite its importance. Although we assume that the remodeling of natural scaffolds may lead to a stable hydrogel, there was not a definitive conclusion that synthetic hydrogels are more beneficial than natural hydrogels in neuronal regeneration.

Rationally Designed, Self‐Assembling, Multifunctional Hydrogel Depot Repairs Severe Spinal Cord Injury

2021 ◽  
pp. 2100242
Author(s):  
Jingjia Ye ◽  
Shuang Jin ◽  
Wanxiong Cai ◽  
Xiangfeng Chen ◽  
Hanyu Zheng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Self Assembling ◽  
Cord Injury

scholarly journals Self-Assembling Nanofibers Inhibit Glial Scar Formation and Promote Axon Elongation after Spinal Cord Injury

2008 ◽  
Vol 28 (14) ◽  
pp. 3814-3823 ◽  
Author(s):  
V. M. Tysseling-Mattiace ◽  
V. Sahni ◽  
K. L. Niece ◽  
D. Birch ◽  
C. Czeisler ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Glial Scar ◽  
Scar Formation ◽  
Axon Elongation ◽  
Self Assembling ◽  
Cord Injury
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