scholarly journals Amorphous Pharmaceutical Solids: Characterization, Stabilization, and Development of Marketable Formulations of Poorly Soluble Drugs with Improved Oral Absorption

2008 ◽  
Vol 5 (6) ◽  
pp. 903-904 ◽  
Author(s):  
Ping Gao
Keyword(s):  
Oral Absorption ◽  
Poorly Soluble Drugs ◽  
Pharmaceutical Solids ◽  
Poorly Soluble

In vitro -in vivo correlation in the effect of cyclodextrin on oral absorption of poorly soluble drugs

2021 ◽  
pp. 120494
Author(s):  
Risa Aihara ◽  
Roman Messerschmid ◽  
Masashi Mizoguchi ◽  
Koichi Wada ◽  
Keiko Minami ◽  
...  
Keyword(s):  
Oral Absorption ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Mechanisms of Membrane Transport of Poorly Soluble Drugs: Role of Micelles in Oral Absorption Processes

2010 ◽  
Vol 99 (3) ◽  
pp. 1336-1345 ◽  
Author(s):  
Koji Yano ◽  
Yoshie Masaoka ◽  
Makoto Kataoka ◽  
Shinji Sakuma ◽  
Shinji Yamashita
Keyword(s):  
Membrane Transport ◽  
Oral Absorption ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Supersaturation–Nucleation Behavior of Poorly Soluble Drugs and its Impact on the Oral Absorption of Drugs in Thermodynamically High-Energy Forms

2012 ◽  
Vol 101 (1) ◽  
pp. 214-222 ◽  
Author(s):  
Shunsuke Ozaki ◽  
Takuma Minamisono ◽  
Taro Yamashita ◽  
Takashi Kato ◽  
Ikuo Kushida
Keyword(s):  
Oral Absorption ◽  
High Energy ◽  
Poorly Soluble Drugs ◽  
Nucleation Behavior ◽  
Poorly Soluble

Physicochemical Properties of Solid Phospholipid Particles as a Drug Delivery Platform for Improving Oral Absorption of Poorly Soluble Drugs

2016 ◽  
Vol 34 (1) ◽  
pp. 208-216 ◽  
Author(s):  
Kohsaku Kawakami ◽  
Aoi Miyazaki ◽  
Mayuko Fukushima ◽  
Keiko Sato ◽  
Yuko Yamamura ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Physicochemical Properties ◽  
Oral Absorption ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble ◽  
Delivery Platform

scholarly journals Enhancement of solubility of poorly soluble drugs by solid dispersion: An Overview

2017 ◽  
Vol 5 (04) ◽  
pp. 17-23
Author(s):  
Katta Manogna ◽  
P. Nagaveni ◽  
K. Thyagaraju
Keyword(s):  
Solid Dispersion ◽  
Oral Absorption ◽  
Water Soluble ◽  
Poorly Soluble Drugs ◽  
Drug Solubility ◽  
Solid Dosage Forms ◽  
Preparation Methods ◽  
Solid Dosage ◽  
Poorly Soluble ◽  
Poorly Water Soluble

Most of the newly invented chemical drug moieties are poorly water soluble. According to BCS classification, class II and IV drugs are considered as poorly water soluble. So enhancement of oral absorption and bioavailability of solid dosage forms remains a challenge to formulation scientists due to their solubility criteria. Therefore many techniques are being explored to enhance the solubility of poor soluble drugs. Solid dispersion is one of the most important method for enhance the solubility (dissolution rate) and hence oral bioavailability of poorly soluble drugs. In solid dispersion the particle size of drug is reduced or a crystalline pure drug is converted into amorphous form and hence the solubility is increased. Polymer incorporating in solid dispersion technology is usually hydrophilic in nature and also showing compatibility with the drug to enhance the drug solubility. This review mainly discus about solid dispersion, preparation methods, and finally characterization.

scholarly journals Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

2019 ◽  
Vol 108 (5) ◽  
pp. 1765-1771 ◽  
Author(s):  
Janneke Keemink ◽  
Erik Sjögren ◽  
René Holm ◽  
Christel A.S. Bergström
Keyword(s):  
Oral Absorption ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble
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