scholarly journals Targeted Delivery of Doxorubicin by Folic Acid-Decorated Dual Functional Nanocarrier

2014 ◽  
Vol 11 (11) ◽  
pp. 4164-4178 ◽  
Author(s):  
Jianqin Lu ◽  
Wenchen Zhao ◽  
Yixian Huang ◽  
Hao Liu ◽  
Rebecca Marquez ◽  
...  
Keyword(s):  
Folic Acid ◽  
Targeted Delivery ◽  
Dual Functional

scholarly journals Correction to “Targeted Delivery of Doxorubicin by Folic Acid-Decorated Dual Functional Nanocarrier”

2019 ◽  
Vol 16 (9) ◽  
pp. 4087-4087
Author(s):  
Jianqin Lu ◽  
Wenchen Zhao ◽  
Yixian Huang ◽  
Hao Liu ◽  
Rebecca Marquez ◽  
...  
Keyword(s):  
Folic Acid ◽  
Targeted Delivery ◽  
Dual Functional

scholarly journals Biodegradable poly(D,L-lactide-co-glycolide)/poly(L-γ-glutamic acid) nanoparticles conjugated to folic acid for targeted delivery of doxorubicin

2017 ◽  
Vol 76 ◽  
pp. 743-751 ◽  
Author(s):  
Laura Jaimes-Aguirre ◽  
Enrique Morales-Avila ◽  
Blanca E. Ocampo-García ◽  
Luis Alberto Medina ◽  
Gustavo López-Téllez ◽  
...  
Keyword(s):  
Folic Acid ◽  
Glutamic Acid ◽  
Targeted Delivery ◽  
Biodegradable Poly

Targeted Delivery and Redox Activity of Folic Acid-Functionalized Nanoceria in Tumor Cells

2018 ◽  
Vol 15 (3) ◽  
pp. 994-1004 ◽  
Author(s):  
James A. Vassie ◽  
John M. Whitelock ◽  
Megan S. Lord
Keyword(s):  
Folic Acid ◽  
Tumor Cells ◽  
Targeted Delivery ◽  
Redox Activity

Effective tumor-targeted delivery of etoposide using chitosan nanoparticles conjugated with folic acid and sulfobetaine methacrylate

RSC Advances ◽  
2016 ◽  
Vol 6 (94) ◽  
pp. 91192-91200 ◽  
Author(s):  
Song Hua ◽  
Jiahua Yu ◽  
Jun Shang ◽  
Haowen Zhang ◽  
Jie Du ◽  
...  
Keyword(s):  
Folic Acid ◽  
Targeted Delivery ◽  
Tumor Targeting ◽  
Chitosan Nanoparticles

FA–CS(VP-16)-g-PSBMA nanoparticles were synthesized and showed effective tumor-targeting properties and promising anti-tumor capacity in vivo.

Immobilization of gold nanoparticles on folate-conjugated dendritic mesoporous silica-coated reduced graphene oxide nanosheets: a new nanoplatform for curcumin pH-controlled and targeted delivery

Soft Matter ◽  
2018 ◽  
Vol 14 (12) ◽  
pp. 2400-2410 ◽  
Author(s):  
Samira Malekmohammadi ◽  
Hassan Hadadzadeh ◽  
Hossein Farrokhpour ◽  
Zahra Amirghofran
Keyword(s):  
Gold Nanoparticles ◽  
Graphene Oxide ◽  
Folic Acid ◽  
Mesoporous Silica ◽  
Reduced Graphene Oxide ◽  
Targeted Delivery ◽  
Cell Imaging ◽  
Graphene Oxide Nanosheets ◽  
Reduced Graphene ◽  
Gold Nps

A nanocarrier for curcumin targeted delivery and cell imaging was prepared by immobilization of gold NPs on the folic acid-modified dendritic mesoporous silica-coated reduced graphene oxide nanosheets.

scholarly journals Effective Targeting of Colon Cancer Cells with Piperine Natural Anticancer Prodrug Using Functionalized Clusters of Hydroxyapatite Nanoparticles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 70 ◽  
Author(s):  
Khaled AbouAitah ◽  
Agata Stefanek ◽  
Iman M. Higazy ◽  
Magdalena Janczewska ◽  
Anna Swiderska-Sroda ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Folic Acid ◽  
Cancer Cells ◽  
Delivery System ◽  
Targeted Delivery ◽  
Gum Arabic ◽  
Colon Cancer Cells ◽  
Hydroxyapatite Nanoparticles ◽  
Anticancer Effects ◽  
Targeted Delivery System

Targeted drug delivery offers great opportunities for treating cancer. Here, we developed a novel anticancer targeted delivery system for piperine (Pip), an alkaloid prodrug derived from black pepper that exhibits anticancer effects. The tailored delivery system comprises aggregated hydroxyapatite nanoparticles (HAPs) functionalized with phosphonate groups (HAP-Ps). Pip was loaded into HAPs and HAP-Ps at pH 7.2 and 9.3 to obtain nanoformulations. The nanoformulations were characterized using several techniques and the release kinetics and anticancer effects investigated in vitro. The Pip loading capacity was >20%. Prolonged release was observed with kinetics dependent on pH, surface modification, and coating. The nanoformulations fully inhibited monolayer HCT116 colon cancer cells compared to Caco2 colon cancer and MCF7 breast cancer cells after 72 h, whereas free Pip had a weaker effect. The nanoformulations inhibited ~60% in HCT116 spheroids compared to free Pip. The Pip-loaded nanoparticles were also coated with gum Arabic and functionalized with folic acid as a targeting ligand. These functionalized nanoformulations had the lowest cytotoxicity towards normal WI-38 fibroblast cells. These preliminary findings suggest that the targeted delivery system comprising HAP aggregates loaded with Pip, coated with gum Arabic, and functionalized with folic acid are a potentially efficient agent against colon cancer.

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