Penetratin, a Potentially Powerful Absorption Enhancer for Noninvasive Intraocular Drug Delivery

2014 ◽  
Vol 11 (4) ◽  
pp. 1218-1227 ◽  
Author(s):  
Chang Liu ◽  
Lingyu Tai ◽  
Wenjian Zhang ◽  
Gang Wei ◽  
Weisan Pan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Absorption Enhancer ◽  
Powerful Absorption ◽  
Intraocular Drug Delivery

An electrochemical intraocular drug delivery device

2008 ◽  
Vol 143 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Po-Ying Li ◽  
Jason Shih ◽  
Ronalee Lo ◽  
Saloomeh Saati ◽  
Rajat Agrawal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Intraocular Drug Delivery

scholarly journals Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 269 ◽  
Author(s):  
Rubén Varela-Fernández ◽  
Victoria Díaz-Tomé ◽  
Andrea Luaces-Rodríguez ◽  
Andrea Conde-Penedo ◽  
Xurxo García-Otero ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
Anatomy And Physiology ◽  
Administration Routes ◽  
Age Related ◽  
Complex Anatomy ◽  
Site Of Action ◽  
Intraocular Drug Delivery ◽  
Novel Drug ◽  
Drug Pharmacokinetics

The treatment of the posterior-segment ocular diseases, such as age-related eye diseases (AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the complex anatomy and physiology of the eye. This specialized organ is composed of various static and dynamic barriers that restrict drug delivery into the target site of action. Despite numerous efforts, effective intraocular drug delivery remains unresolved and, therefore, it is highly desirable to improve the current treatments of diseases affecting the posterior cavity. This review article gives an overview of pharmacokinetic and biopharmaceutics aspects for the most commonly-used ocular administration routes (intravitreal, topical, systemic, and periocular), including information of the absorption, distribution, and elimination, as well as the benefits and limitations of each one. This article also encompasses different conventional and novel drug delivery systems designed and developed to improve drug pharmacokinetics intended for the posterior ocular segment treatment.

scholarly journals Nanospheres Delivering the EGFR TKI AG1478 Promote Optic Nerve Regeneration: The Role of Size for Intraocular Drug Delivery

ACS Nano ◽  
2011 ◽  
Vol 5 (6) ◽  
pp. 4392-4400 ◽  
Author(s):  
Rebecca Robinson ◽  
Stephen R. Viviano ◽  
Jason M. Criscione ◽  
Cicely A. Williams ◽  
Lin Jun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optic Nerve ◽  
Nerve Regeneration ◽  
Optic Nerve Regeneration ◽  
Intraocular Drug Delivery ◽  
Egfr Tki

scholarly journals Critical Assessment of Implantable Drug Delivery Devices in Glaucoma Management

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Dharani Manickavasagam ◽  
Moses O. Oyewumi
Keyword(s):  
Drug Delivery ◽  
Ganglion Cells ◽  
Drug Stability ◽  
Unmet Need ◽  
Delivery Systems ◽  
Therapeutic Interventions ◽  
Future Research ◽  
Drug Bioavailability ◽  
Intraocular Drug Delivery ◽  
Drug Delivery Devices

Glaucoma is a group of heterogeneous disorders involving progressive optic neuropathy that can culminate into visual impairment and irreversible blindness. Effective therapeutic interventions must address underlying vulnerability of retinal ganglion cells (RGCs) to degeneration in conjunction with correcting other associated risk factors (such as elevated intraocular pressure). However, realization of therapeutic outcomes is heavily dependent on suitable delivery system that can overcome myriads of anatomical and physiological barriers to intraocular drug delivery. Development of clinically viable sustained release systems in glaucoma is a widely recognized unmet need. In this regard, implantable delivery systems may relieve the burden of chronic drug administration while potentially ensuring high intraocular drug bioavailability. Presently there are no FDA-approved implantable drug delivery devices for glaucoma even though there are several ongoing clinical studies. The paper critically assessed the prospects of polymeric implantable delivery systems in glaucoma while identifying factors that can dictate (a) patient tolerability and acceptance, (b) drug stability and drug release profiles, (c) therapeutic efficacy, and (d) toxicity and biocompatibility. The information gathered could be useful in future research and development efforts on implantable delivery systems in glaucoma.

scholarly journals Characterization of a Novel Intraocular Drug-Delivery System Using Crystalline Lipid Antiviral Prodrugs of Ganciclovir and Cyclic Cidofovir

2004 ◽  
Vol 45 (11) ◽  
pp. 4138 ◽  
Author(s):  
Lingyun Cheng ◽  
Karl Y. Hostetler ◽  
Jeffery Lee ◽  
Hyoung Jun Koh ◽  
James R. Beadle ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Intraocular Drug Delivery

Polysulfone Capillary Fiber for Intraocular Drug Delivery: In Vitro and in Vivo Evaluations

1994 ◽  
Vol 2 (4) ◽  
pp. 289-298 ◽  
Author(s):  
M. H. Rahimy ◽  
G. A. Peyman ◽  
S. Y. Chin ◽  
R. Golshani ◽  
C. Aras ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Intraocular Drug Delivery
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