scholarly journals Nanospheres Delivering the EGFR TKI AG1478 Promote Optic Nerve Regeneration: The Role of Size for Intraocular Drug Delivery

ACS Nano ◽  
2011 ◽  
Vol 5 (6) ◽  
pp. 4392-4400 ◽  
Author(s):  
Rebecca Robinson ◽  
Stephen R. Viviano ◽  
Jason M. Criscione ◽  
Cicely A. Williams ◽  
Lin Jun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optic Nerve ◽  
Nerve Regeneration ◽  
Optic Nerve Regeneration ◽  
Intraocular Drug Delivery ◽  
Egfr Tki

Interactions between compound and normal eye projections in dually innervated tectum: a study of optic nerve regeneration in Xenopus

Development ◽  
1981 ◽  
Vol 66 (1) ◽  
pp. 159-174
Author(s):  
Charles Straznicky ◽  
David Tay
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Compound Eye ◽  
Compound Eyes ◽  
Lateral Region ◽  
Optic Nerve Regeneration ◽  
Xenopus Embryos ◽  
Retinotectal Projections ◽  
Two Populations

Right compound eyes were formed in Xenopus embryos at tailbud stages by the fusion of two nasal (NN), two temporal (TT) or two ventral (VV) halves. The left eye was kept intact. Two to four weeks after metamorphosis the optic nerve from the intact eye was severed to induce bilateral optic nerve regeneration. The contralateral retinotectal projections from the compound eye and the induced ipsilateral projections from the intact eye to the same (dually innervated) tectum were studied by [3H]proline autoradiography and visuotectal mapping from 3 to 6 months after the postmetamorphic surgery. The results showed that the NN, TT and VV projections, in the presence of optic fibres from the intact eye failed to spread across the whole extent of the dually innervated tectum. Unexpectedly the bulk of the regenerating projection from the intact eye was confined to the previously uninnervated parts of the dually innervated tecta, the caudomedial region in TT, the rostrolateral region in NN and the lateral region in VV eye animals. The partial segregation of the two populations of optic fibres in the dually innervated tectum has been taken as a further indication of the role of fibre-fibre and fibre-tectum interactions in retinotectal map formation.

scholarly journals The role of macrophages in optic nerve regeneration

Neuroscience ◽  
2009 ◽  
Vol 158 (3) ◽  
pp. 1039-1048 ◽  
Author(s):  
Q. Cui ◽  
Y. Yin ◽  
L.I. Benowitz
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Optic Nerve Regeneration

scholarly journals Novel role of Lin28 signaling in regulation of mammalian PNS and CNS axon regeneration

2018 ◽  
Author(s):  
Xue-Wei Wang ◽  
Chang-Mei Liu ◽  
Philip A. Hall ◽  
Jing-Jing Jiang ◽  
Christopher D. Katchis ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Axon Regeneration ◽  
Ganglion Cells ◽  
Cellular Reprogramming ◽  
Optic Nerve Regeneration ◽  
Reprogramming Factors ◽  
Necessary And Sufficient

SummarySeveral signaling molecules involved in cellular reprogramming have been shown to regulate mammalian axon regeneration. We hypothesized that reprogramming factors are key regulators of axon regeneration. Here we investigated the role of Lin28, an important reprogramming factor, in the regulation of axon regeneration. We found that Lin28a and Lin28b and their regulatory partners, let-7 microRNAs (miRNAs), were both necessary and sufficient in regulating mature sensory axon regeneration in vivo. More importantly, overexpression of either Lin28a or Lin28b in mature retinal ganglion cells (RGCs) promoted robust and sustained optic nerve regeneration. Additionally, combined overexpression of Lin28a and downregulation of PTEN in RGCs acted additively to promote optic nerve regeneration by reducing the backward turning of regenerating RGC axons. Our findings not only identified a novel molecule promoting optic nerve regeneration but also suggested that reprogramming factors may play vital roles in regulating axon regeneration in mammals.

Müller glia–myeloid cell crosstalk accelerates optic nerve regeneration in the adult zebrafish

Glia ◽  
2021 ◽  
Author(s):  
Annelies Van Dyck ◽  
Ilse Bollaerts ◽  
An Beckers ◽  
Sophie Vanhunsel ◽  
Nynke Glorian ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Myeloid Cell ◽  
Muller Glia ◽  
Müller Glia ◽  
Adult Zebrafish ◽  
Optic Nerve Regeneration ◽  
Cell Crosstalk

A vulnerable period of colchicine toxicity during goldfish optic nerve regeneration

1999 ◽  
Vol 842 (1) ◽  
pp. 62-72 ◽  
Author(s):  
Joseph A Dybowski ◽  
Anne M Heacock ◽  
Bernard W Agranoff
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Optic Nerve Regeneration ◽  
Vulnerable Period

scholarly journals zRICH, a protein induced during optic nerve regeneration in zebrafish, promotes neuritogenesis and interacts with tubulin

2012 ◽  
Vol 1474 ◽  
pp. 29-39 ◽  
Author(s):  
Satya S. Pathi ◽  
Soumia Jose ◽  
Suman Govindaraju ◽  
Juan A. Conde ◽  
Hannah E. Romo ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Optic Nerve Regeneration

scholarly journals Successful optic nerve regeneration in the senescent zebrafish despite age-related decline of cell intrinsic and extrinsic response processes

2017 ◽  
Vol 60 ◽  
pp. 1-10 ◽  
Author(s):  
Jessie Van houcke ◽  
Ilse Bollaerts ◽  
Emiel Geeraerts ◽  
Benjamin Davis ◽  
An Beckers ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Nerve Regeneration ◽  
Optic Nerve Regeneration ◽  
Age Related
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