Enhanced Brain Delivery of Deferasirox–Lactoferrin Conjugates for Iron Chelation Therapy in Neurodegenerative Disorders: In Vitro and in Vivo Studies

2013 ◽  
Vol 10 (12) ◽  
pp. 4418-4431 ◽  
Author(s):  
Golnaz Kamalinia ◽  
Fariba Khodagholi ◽  
Fatemeh Atyabi ◽  
Mohsen Amini ◽  
Fatemeh Shaerzadeh ◽  
...  
Keyword(s):  
Neurodegenerative Disorders ◽  
Chelation Therapy ◽  
Iron Chelation ◽  
In Vivo Studies ◽  
Brain Delivery ◽  
Iron Chelation Therapy

Brain delivery of camptothecin by means of solid lipid nanoparticles: Formulation design, in vitro and in vivo studies

2012 ◽  
Vol 439 (1-2) ◽  
pp. 49-62 ◽  
Author(s):  
Susana Martins ◽  
Ingunn Tho ◽  
Isolde Reimold ◽  
Gert Fricker ◽  
Eliana Souto ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Studies ◽  
Brain Delivery ◽  
Formulation Design ◽  
Solid Lipid

scholarly journals The effect of surface treatment on the brain delivery of curcumin nanosuspension: in vitro and in vivo studies

2019 ◽  
Vol Volume 14 ◽  
pp. 5477-5490 ◽  
Author(s):  
Maryam Dibaei ◽  
Mohammad-Reza Rouini ◽  
Behjat Sheikholeslami ◽  
Mahdi Gholami ◽  
Rassoul Dinarvand
Keyword(s):  
Surface Treatment ◽  
In Vivo Studies ◽  
Brain Delivery ◽  
The Brain ◽  
Effect Of Surface

scholarly journals Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application

Materials ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3495
Author(s):  
Adriana Trapani ◽  
Filomena Corbo ◽  
Gennaro Agrimi ◽  
Nicoletta Ditaranto ◽  
Nicola Cioffi ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Near Field ◽  
Neuroblastoma Cell ◽  
Fluorescein Isothiocyanate ◽  
Neuroblastoma Cell Line ◽  
In Vivo Studies ◽  
Brain Delivery ◽  
In Vitro Characterization

Background: The blood–brain barrier (BBB) bypass of dopamine (DA) is still a challenge for supplying it to the neurons of Substantia Nigra mainly affected by Parkinson disease. DA prodrugs have been studied to cross the BBB, overcoming the limitations of DA hydrophilicity. Therefore, the aim of this work is the synthesis and preliminary characterization of an oxidized alginate-dopamine (AlgOX-DA) conjugate conceived for DA nose-to-brain delivery. Methods: A Schiff base was designed to connect oxidized polymeric backbone to DA and both AlgOX and AlgOX-DA were characterized in terms of Raman, XPS, FT-IR, and 1H- NMR spectroscopies, as well as in vitro mucoadhesive and release tests. Results: Data demonstrated that AlgOX-DA was the most mucoadhesive material among the tested ones and it released the neurotransmitter in simulated nasal fluid and in low amounts in phosphate buffer saline. Results also demonstrated the capability of scanning near-field optical microscopy to study the structural and fluorescence properties of AlgOX, fluorescently labeled with fluorescein isothiocyanate microstructures. Interestingly, in SH-SY5Y neuroblastoma cell line up to 100 μg/mL, no toxic effect was derived from AlgOX and AlgOX-DA in 24 h. Conclusions: Overall, the in vitro performances of AlgOX and AlgOX-DA conjugates seem to encourage further ex vivo and in vivo studies in view of nose-to-brain administration.

Enhancement of the Brain Delivery of Methotrexate with Administration of Mid-chain Ester Prodrugs: In vitro and In vivo Studies

2021 ◽  
pp. 120479
Author(s):  
Nadia Fattahi ◽  
Ali Ramazani ◽  
Mehrdad Hamidi ◽  
Maliheh Parsa ◽  
Kobra Rostamizadeh ◽  
...  
Keyword(s):  
In Vivo Studies ◽  
Brain Delivery ◽  
The Brain ◽  
Ester Prodrugs ◽  
Chain Ester

Synchronizing In Silico, In Vitro, and In Vivo Studies for the Successful Nose to Brain Delivery of an Anticancer Molecule

2021 ◽  
Vol 18 (10) ◽  
pp. 3763-3776
Author(s):  
Shaymaa A. Abd-algaleel ◽  
Abdelkader A. Metwally ◽  
Hend Mohamed Abdel-Bar ◽  
Dina H. Kassem ◽  
Rania M. Hathout
Keyword(s):  
In Silico ◽  
In Vivo Studies ◽  
Brain Delivery

Imbir lekarski ? roślina o właściwościach neuroochronnych

2019 ◽  
Vol 20 (4) ◽  
Author(s):  
Dominika Łażewska ◽  
Kinga Miętkiewska ◽  
Elżbieta Studzińska-Sroka
Keyword(s):  
Neurodegenerative Disorders ◽  
Chemical Compounds ◽  
Zingiber Officinale ◽  
Raw Material ◽  
In Vivo Studies ◽  
Neuroprotective Activity ◽  
Subtropical Zone ◽  
Loss Of Appetite

Ginger (Zingiber officinale Rosc.) is a perennial belonging to Zingiberaceae family. Primary place of occurrence was Asia, but nowadays it is grown in many regions of subtropical zone. The raw material used in medicine is a rhizome and oil obtained from it. Chemical compounds responsible for pharmacological activity are mainly sesquiterpene alcohols, gingerols and shogaols. Among beneficial properties of ginger we can list: promoting salivation, stimulating secretion of gastric juice and bile, reducing cholesterol level, improving immunity, activating peristalsis of the intestines and antioxidative, antibacterial, antiviral, anticoagulant and anti-inflammatory properties. Confirmed indications are loss of appetite, dyspepsia and motion sickness. In this paper we described scientific reports considering potential neuroprotective activity of ginger, which can be used in treatment of neurodegenerative disorders as Alzheimer’s disease. We presented the results of in vitro and in vivo studies. The article contains information on the safety of products from Z. officinale.

In silico Exploration of Bioactive Phytochemicals Against Neurodegenerative Diseases Via Inhibition of Cholinesterases

2020 ◽  
Vol 26 (33) ◽  
pp. 4151-4162 ◽  
Author(s):  
Fawzi Mahomoodally ◽  
Hassan H. Abdallah ◽  
Shanoo Suroowan ◽  
Sharmeen Jugreet ◽  
Yansheng Zhang ◽  
...  
Keyword(s):  
Neurodegenerative Disorders ◽  
In Silico ◽  
Randomized Clinical Trials ◽  
Synaptic Cleft ◽  
Docking Studies ◽  
In Vivo Studies ◽  
In Silico Docking ◽  
Long Term Treatment

Neurodegenerative disorders are estimated to become the second leading cause of death worldwide by 2040. Despite the widespread use of diverse allopathic drugs, these brain-associated disorders can only be partially addressed and long term treatment is often linked with dependency and other unwanted side effects. Nature, believed to be an arsenal of remedies for any illness, presents an interesting avenue for the development of novel neuroprotective agents. Interestingly, inhibition of cholinesterases, involved in the breakdown of acetylcholine in the synaptic cleft, has been proposed to be neuroprotective. This review therefore aims to provide additional insight via docking studies of previously studied compounds that have shown potent activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro. Indeed, the determination of potent plant-based ligands for this purpose through in silico methods enables the elimination of lengthy and costly traditional methods of drug discovery. Herein, a literature search was conducted to identify active phytochemicals which are cholinesterase inhibitors. Following which in silico docking methods were applied to obtain docking scores. Compound structures were extracted from online ZINC database and optimized using AM1 implemented in gaussian09 software. Noteworthy ligands against AChE highlighted in this study include: 19,20-dihydroervahanine A and 19, 20-dihydrotabernamine. Regarding BChE inhibition, the best ligands were found to be 8-Clavandurylkaempferol, Na-methylepipachysamine D; ebeiedinone; and dictyophlebine. Thus, ligand optimization between such phytochemicals and cholinesterases coupled with in vitro, in vivo studies and randomized clinical trials can lead to the development of novel drugs against neurodegenerative disorders.

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