Development and evaluation of olanzapine-loaded PLGA nanoparticles for nose-to-brain delivery: In vitro and in vivo studies

2011 ◽  
Vol 7 (12) ◽  
pp. 4169-4176 ◽  
Author(s):  
U. Seju ◽  
A. Kumar ◽  
K.K. Sawant
Keyword(s):  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Brain Delivery

Use of mPEG-PLGA nanoparticles to improve bioactivity and hemocompatibility of streptokinase: In-vitro and in-vivo studies

2021 ◽  
Vol 118 ◽  
pp. 111427
Author(s):  
Akram Hasanpour ◽  
Fariba Esmaeili ◽  
Hossein Hosseini ◽  
Amir Amani
Keyword(s):  
Plga Nanoparticles ◽  
In Vivo Studies

Brain delivery of camptothecin by means of solid lipid nanoparticles: Formulation design, in vitro and in vivo studies

2012 ◽  
Vol 439 (1-2) ◽  
pp. 49-62 ◽  
Author(s):  
Susana Martins ◽  
Ingunn Tho ◽  
Isolde Reimold ◽  
Gert Fricker ◽  
Eliana Souto ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
In Vivo Studies ◽  
Brain Delivery ◽  
Formulation Design ◽  
Solid Lipid

Carbamazepine and levetiracetam-loaded PLGA nanoparticles prepared by nanoprecipitation method: in vitro and in vivo studies

2020 ◽  
Vol 46 (7) ◽  
pp. 1063-1072
Author(s):  
Busra Kandilli ◽  
Afife Busra Ugur Kaplan ◽  
Meltem Cetin ◽  
Numan Taspinar ◽  
Muhammed Sait Ertugrul ◽  
...  
Keyword(s):  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Nanoprecipitation Method

scholarly journals The effect of surface treatment on the brain delivery of curcumin nanosuspension: in vitro and in vivo studies

2019 ◽  
Vol Volume 14 ◽  
pp. 5477-5490 ◽  
Author(s):  
Maryam Dibaei ◽  
Mohammad-Reza Rouini ◽  
Behjat Sheikholeslami ◽  
Mahdi Gholami ◽  
Rassoul Dinarvand
Keyword(s):  
Surface Treatment ◽  
In Vivo Studies ◽  
Brain Delivery ◽  
The Brain ◽  
Effect Of Surface

scholarly journals Garcinol loaded vitamin E TPGS emulsified PLGA nanoparticles: preparation, physicochemical characterization, in vitro and in vivo studies

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Raghuvir H. Gaonkar ◽  
Soumya Ganguly ◽  
Saikat Dewanjee ◽  
Samarendu Sinha ◽  
Amit Gupta ◽  
...  
Keyword(s):  
Vitamin E ◽  
Physicochemical Characterization ◽  
Plga Nanoparticles ◽  
In Vivo Studies ◽  
Vitamin E Tpgs

scholarly journals Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application

Materials ◽  
2021 ◽  
Vol 14 (13) ◽  
pp. 3495
Author(s):  
Adriana Trapani ◽  
Filomena Corbo ◽  
Gennaro Agrimi ◽  
Nicoletta Ditaranto ◽  
Nicola Cioffi ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Near Field ◽  
Neuroblastoma Cell ◽  
Fluorescein Isothiocyanate ◽  
Neuroblastoma Cell Line ◽  
In Vivo Studies ◽  
Brain Delivery ◽  
In Vitro Characterization

Background: The blood–brain barrier (BBB) bypass of dopamine (DA) is still a challenge for supplying it to the neurons of Substantia Nigra mainly affected by Parkinson disease. DA prodrugs have been studied to cross the BBB, overcoming the limitations of DA hydrophilicity. Therefore, the aim of this work is the synthesis and preliminary characterization of an oxidized alginate-dopamine (AlgOX-DA) conjugate conceived for DA nose-to-brain delivery. Methods: A Schiff base was designed to connect oxidized polymeric backbone to DA and both AlgOX and AlgOX-DA were characterized in terms of Raman, XPS, FT-IR, and 1H- NMR spectroscopies, as well as in vitro mucoadhesive and release tests. Results: Data demonstrated that AlgOX-DA was the most mucoadhesive material among the tested ones and it released the neurotransmitter in simulated nasal fluid and in low amounts in phosphate buffer saline. Results also demonstrated the capability of scanning near-field optical microscopy to study the structural and fluorescence properties of AlgOX, fluorescently labeled with fluorescein isothiocyanate microstructures. Interestingly, in SH-SY5Y neuroblastoma cell line up to 100 μg/mL, no toxic effect was derived from AlgOX and AlgOX-DA in 24 h. Conclusions: Overall, the in vitro performances of AlgOX and AlgOX-DA conjugates seem to encourage further ex vivo and in vivo studies in view of nose-to-brain administration.

Enhancement of the Brain Delivery of Methotrexate with Administration of Mid-chain Ester Prodrugs: In vitro and In vivo Studies

2021 ◽  
pp. 120479
Author(s):  
Nadia Fattahi ◽  
Ali Ramazani ◽  
Mehrdad Hamidi ◽  
Maliheh Parsa ◽  
Kobra Rostamizadeh ◽  
...  
Keyword(s):  
In Vivo Studies ◽  
Brain Delivery ◽  
The Brain ◽  
Ester Prodrugs ◽  
Chain Ester
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