Reversal of Multidrug Resistance by Mitochondrial Targeted Self-Assembled Nanocarrier Based on Stearylamine

2013 ◽  
Vol 10 (6) ◽  
pp. 2426-2434 ◽  
Author(s):  
Zhiwen Zhang ◽  
Zeying Liu ◽  
Li Ma ◽  
Shijun Jiang ◽  
Yixin Wang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Self Assembled

scholarly journals Apoptosis-independent organoruthenium anticancer complexes that overcome multidrug resistance: self-assembly and phenotypic screening strategies

2017 ◽  
Vol 8 (5) ◽  
pp. 3641-3649 ◽  
Author(s):  
Mun Juinn Chow ◽  
Mohammad Alfiean ◽  
Giorgia Pastorin ◽  
Christian Gaiddon ◽  
Wee Han Ang
Keyword(s):  
Multidrug Resistance ◽  
Self Assembly ◽  
Phenotypic Screening ◽  
Screening Strategies ◽  
Anticancer Complexes ◽  
Self Assembled

Phenotypic screening on a library of combinatorial self-assembled organoruthenium complexes revealed constructs that act on refractory cancers via apoptosis-independent pathways.

Supramolecularly self-assembled nano-twin drug for reversing multidrug resistance

2018 ◽  
Vol 6 (8) ◽  
pp. 2261-2269 ◽  
Author(s):  
Chenwei Wu ◽  
Li Xu ◽  
Leilei Shi ◽  
Xihui Gao ◽  
Jing Li ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Therapy ◽  
New Approach ◽  
Self Assembled

A new approach to reverse the multidrug resistance for cancer therapy.

A self-assembled albumin based multiple drug delivery nanosystem to overcome multidrug resistance

RSC Advances ◽  
2015 ◽  
Vol 5 (9) ◽  
pp. 6807-6814 ◽  
Author(s):  
Bin Chen ◽  
Cong Wu ◽  
Ren-Xi Zhuo ◽  
Si-Xue Cheng
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Multidrug Resistance ◽  
Drug Delivery System ◽  
Delivery System ◽  
Multiple Drug ◽  
Self Assembled ◽  
Multiple Drug Delivery

A self-assembled nano-sized albumin based drug delivery system co-loaded with an anti-tumor drug and a drug resistance inhibitor has promising applications in overcoming multidrug resistance (MDR).

scholarly journals Docetaxel-Loaded Chitosan-Cholesterol Conjugate-Based Self-Assembled Nanoparticles for Overcoming Multidrug Resistance in Cancer Cells

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 783
Author(s):  
Chao-Feng Mu ◽  
Fude Cui ◽  
Yong-Mei Yin ◽  
Hyun-Jong Cho ◽  
Dae-Duk Kim
Keyword(s):  
Multidrug Resistance ◽  
Zeta Potential ◽  
Cancer Cells ◽  
In Vitro Release ◽  
Spherical Shape ◽  
Entrapment Efficiency ◽  
Hydrodynamic Diameter ◽  
Anticancer Drug Delivery ◽  
Self Assembled

Cholesteryl hemisuccinate (CHS)-conjugated chitosan (CS)-based self-assembled nanoparticles (NPs) were developed for enhancing the intracellular uptake of docetaxel in multidrug resistance (MDR)-acquired cancer cells. CHS-CS was successfully synthesized and self-aggregation, particle size, zeta potential, drug entrapment efficiency, and in vitro drug release of docetaxel-loaded CHS-CS NPs were tested. The optimized NPs had a mean hydrodynamic diameter of 303 nm, positive zeta potential of 21.3 mV, and spherical shape. The in vitro release of docetaxel from the optimized CHS-CS NPs in different pH medium (pH 6.0 and 7.4) revealed that the release was improved in a more acidic condition (pH 6.0), representing a tumor cell’s environment. The superior MDR-overcoming effect of docetaxel-loaded CHS-CS NPs, compared with docetaxel solution, was verified in anti-proliferation and cellular accumulation studies in MDR-acquired KBV20C cells. Thus, CHS-CS NPs could be potentially used for overcoming the MDR effect in anticancer drug delivery.

A self-assembled pH/enzyme dual-responsive prodrug with PEG deshielding for multidrug-resistant tumor therapy

2020 ◽  
Vol 8 (6) ◽  
pp. 1290-1301 ◽  
Author(s):  
Ronghua Ni ◽  
Jianhua Zhu ◽  
Zhiyuan Xu ◽  
Yun Chen
Keyword(s):  
Multidrug Resistance ◽  
Tumor Therapy ◽  
Multidrug Resistant ◽  
Dual Responsive ◽  
Self Assembled

Multidrug resistance (MDR) is one of the major obstacles for tumor therapy.

Overcoming Multidrug Resistance in Microbials Using Nanostructures Self-Assembled from Cationic Bent-Core Oligomers

Small ◽  
2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Shao Qiong Liu ◽  
Shrinivas Venkataraman ◽  
Zhan Yuin Ong ◽  
Julian M. W. Chan ◽  
Chuan Yang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Self Assembled

Paclitaxel loaded self-assembled nanocarrier reduces multidrug resistance in lung cancer

2013 ◽  
Vol 172 (1) ◽  
pp. e96
Author(s):  
Zhiwen Zhang ◽  
Huihui Bu ◽  
Zeying Liu ◽  
Yixin Wang ◽  
Baohua Niu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multidrug Resistance ◽  
Self Assembled

scholarly journals Stimuli-responsive nanodrug self-assembled from amphiphilic drug-inhibitor conjugate for overcoming multidrug resistance in cancer treatment

Theranostics ◽  
2019 ◽  
Vol 9 (20) ◽  
pp. 5755-5768 ◽  
Author(s):  
Ping Huang ◽  
Guanchun Wang ◽  
Yue Su ◽  
Yongfeng Zhou ◽  
Wei Huang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Treatment ◽  
Stimuli Responsive ◽  
Amphiphilic Drug ◽  
Self Assembled

Chemosensitizing micelles self-assembled from amphiphilic TPGS-indomethacin twin drug for significantly synergetic multidrug resistance reversal

2020 ◽  
pp. 088532822097517
Author(s):  
Ran Chen* ◽  
Zhexiang Wang* ◽  
Shuo Wu ◽  
Xingyu Kuang ◽  
Xiu Wang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Glycoprotein P ◽  
Long Term Stability ◽  
Resistance Reversal ◽  
Self Assembled ◽  
Poly Ethylene ◽  
Synergistic Cytotoxic Effect ◽  
Mdr Reversal ◽  
Mcf 7

Vitamin E d-ɑ-tocopheryl poly(ethylene glycol) 1000 succinate (TPGS) and indomethacin (IDM) can reverse multidrug resistance (MDR) via inhibiting P-glycoprotein (P-gp) and multidrug resistance associated protein 1 (MRP1) respectively, but their drawbacks in physicochemical properties limit their clinical application. To overcome these defects and enhance MDR reversal, the amphiphilic TPGS-IDM twin drug was successfully synthesized via esterification, and could self-assemble into free and paclitaxel-loaded (PTX-loaded) micelles. The micelles exhibited lower CMC values (5.2 × 10−5 mg/mL), long-term stability in PBS (pH 7.4) for 7 days and SDS solution (5 mg/mL) for 3 days, and effective drug release at esterase/pH 5.0. Moreover, the micelles could down-regulate ATP levels and promote ROS production in MCF-7/ADR via the mitochondrial impairment, therefore achieving MDR reversal and cell apoptosis. Additionally, the PTX-loaded micelles could significantly inhibit the cell proliferation and promote apoptosis for MCF-7/ADR via the synergistic chemosensitizing effect of TPGS and IDM, and synergistic cytotoxic effect of TPGS and PTX. Thus, the chemosensitizing micelles self-assembled from amphiphilic TPGS-indomethacin twin drug have the great potentials for reversing MDR in clinical cancer therapy.

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