In Vitro Efficacy of Paclitaxel-Loaded Dual-Responsive Shell Cross-Linked Polymer Nanoparticles Having Orthogonally Degradable Disulfide Cross-Linked Corona and Polyester Core Domains

2013 ◽  
Vol 10 (3) ◽  
pp. 1092-1099 ◽  
Author(s):  
Sandani Samarajeewa ◽  
Ritu Shrestha ◽  
Mahmoud Elsabahy ◽  
Amolkumar Karwa ◽  
Ang Li ◽  
...  
Keyword(s):  
Polymer Nanoparticles ◽  
Dual Responsive

scholarly journals In Vitro and In Vivo Imaging of Peptide-Encapsulated Polymer Nanoparticles for Cancer Biomarker Activated Drug Delivery

2013 ◽  
Vol 12 (4) ◽  
pp. 304-310 ◽  
Author(s):  
Gulsim K. Kulsharova ◽  
Matthew B. Lee ◽  
Felice Cheng ◽  
Munima Haque ◽  
Hyungsoo Choi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
In Vivo Imaging ◽  
Cancer Biomarker ◽  
Polymer Nanoparticles

scholarly journals Fluorescent Polymer Nanoparticles for Cell Barcoding In Vitro and In Vivo

Small ◽  
2017 ◽  
Vol 13 (38) ◽  
pp. 1701582 ◽  
Author(s):  
Bohdan Andreiuk ◽  
Andreas Reisch ◽  
Marion Lindecker ◽  
Gautier Follain ◽  
Nadine Peyriéras ◽  
...  
Keyword(s):  
Polymer Nanoparticles ◽  
Fluorescent Polymer

A cis-Diol/pH Dual-Responsive Upconversion Nanoplatform: Synthesis, Characterization, and In Vitro Demonstration

2019 ◽  
Vol 15 (3) ◽  
pp. 487-499
Author(s):  
Hui Cui ◽  
Bowen Zhang ◽  
Haolin Ding ◽  
Youming Hu ◽  
Xianhua Wang ◽  
...  
Keyword(s):  
Dual Responsive

Fabrication and in vitro performance of a dual responsive lactate and glucose biosensor

2018 ◽  
Vol 267 ◽  
pp. 71-79 ◽  
Author(s):  
Christian N. Kotanen ◽  
Olukayode Karunwi ◽  
Fouzan Alam ◽  
Catherine F.T. Uyehara ◽  
Anthony Guiseppi-Elie
Keyword(s):  
Glucose Biosensor ◽  
Dual Responsive ◽  
In Vitro Performance

scholarly journals Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3089
Author(s):  
Junda Zhang ◽  
Vadde Ramu ◽  
Xue-Quan Zhou ◽  
Carolina Frias ◽  
Daniel Ruiz-Molina ◽  
...  
Keyword(s):  
Coordination Polymer ◽  
High Performance ◽  
Green Light ◽  
Fold Increase ◽  
Polymer Nanoparticles ◽  
Light Irradiation ◽  
Bridging Ligands ◽  
Monomeric Complex ◽  
First Time

Green light photoactive Ru-based coordination polymer nanoparticles (CPNs), with chemical formula [[Ru(biqbpy)]1.5(bis)](PF6)3 (biqbpy = 6,6′-bis[N-(isoquinolyl)-1-amino]-2,2′-bipyridine; bis = bis(imidazol-1-yl)-hexane), were obtained through polymerization of the trans-[Ru(biqbpy)(dmso)Cl]Cl complex (Complex 1) and bis bridging ligands. The as-synthesized CPNs (50 ± 12 nm diameter) showed high colloidal and chemical stability in physiological solutions. The axial bis(imidazole) ligands coordinated to the ruthenium center were photosubstituted by water upon light irradiation in aqueous medium to generate the aqueous substituted and active ruthenium complexes. The UV-Vis spectral variations observed for the suspension upon irradiation corroborated the photoactivation of the CPNs, while High Performance Liquid Chromatography (HPLC) of irradiated particles in physiological media allowed for the first time precisely quantifying the amount of photoreleased complex from the polymeric material. In vitro studies with A431 and A549 cancer cell lines revealed an 11-fold increased uptake for the nanoparticles compared to the monomeric complex [Ru(biqbpy)(N-methylimidazole)2](PF6)2 (Complex 2). After irradiation (520 nm, 39.3 J/cm2), the CPNs yielded up to a two-fold increase in cytotoxicity compared to the same CPNs kept in the dark, indicating a selective effect by light irradiation. Meanwhile, the absence of 1O2 production from both nanostructured and monomeric prodrugs concluded that light-induced cell death is not caused by a photodynamic effect but rather by photoactivated chemotherapy.

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