scholarly journals Fluorescent Polymer Nanoparticles for Cell Barcoding In Vitro and In Vivo

Small ◽  
2017 ◽  
Vol 13 (38) ◽  
pp. 1701582 ◽  
Author(s):  
Bohdan Andreiuk ◽  
Andreas Reisch ◽  
Marion Lindecker ◽  
Gautier Follain ◽  
Nadine Peyriéras ◽  
...  
Keyword(s):  
Polymer Nanoparticles ◽  
Fluorescent Polymer

Preparation of polyacrylic acid surface-crosslinked strong fluorescent polymer nanoparticles and their sensitive in vitro imaging of cancer cells and long-life in vivo imaging of in situ tumors

2017 ◽  
Vol 9 (33) ◽  
pp. 4797-4807 ◽  
Author(s):  
Xue-Ping Cai ◽  
Huan-Huan He ◽  
Hai-Yang Ding ◽  
Xiao-Bo Chen ◽  
Tong-Hong Wei ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Polyacrylic Acid ◽  
In Vivo Imaging ◽  
Polymer Nanoparticles ◽  
Long Life ◽  
Fluorescent Polymer

Preparation of polyacrylic acid surface-crosslinked fluorescent polymer nanoparticles and their sensitive in vitro and long-lived in vivo imaging for cancer cells.

scholarly journals In Vitro and In Vivo Imaging of Peptide-Encapsulated Polymer Nanoparticles for Cancer Biomarker Activated Drug Delivery

2013 ◽  
Vol 12 (4) ◽  
pp. 304-310 ◽  
Author(s):  
Gulsim K. Kulsharova ◽  
Matthew B. Lee ◽  
Felice Cheng ◽  
Munima Haque ◽  
Hyungsoo Choi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
In Vivo Imaging ◽  
Cancer Biomarker ◽  
Polymer Nanoparticles

AIE-active conjugated polymer nanoparticles with red-emission for in vitro and in vivo imaging

RSC Advances ◽  
2016 ◽  
Vol 6 (115) ◽  
pp. 114580-114586 ◽  
Author(s):  
Dongliang Yang ◽  
Shuwei Zhang ◽  
Yanling Hu ◽  
Jia Chen ◽  
Biqing Bao ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Conjugated Polymer ◽  
Fluorescence Emission ◽  
Polymer Nanoparticles ◽  
Red Emission ◽  
Bright Fluorescence ◽  
Conjugated Polymer Nanoparticles ◽  
Excellent Photostability

Novel AIE-active conjugated polymer nanoparticles with bright fluorescence emission and excellent photostability have been prepared for imaging in cells and zebrafish.

scholarly journals Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Simultaneous Use in Magnetic Resonance and Fluorescent Imaging of Brain Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1258
Author(s):  
N. Arias-Ramos ◽  
L. E. Ibarra ◽  
M. Serrano-Torres ◽  
B. Yagüe ◽  
M. D. Caverzán ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Conjugated Polymer ◽  
Colloidal Stability ◽  
Fluorescent Imaging ◽  
Polymer Nanoparticles ◽  
Biodistribution Studies ◽  
Conjugated Polymer Nanoparticles ◽  
Theranostic Agents

Conjugated polymer nanoparticles (CPNs) have emerged as advanced polymeric nanoplatforms in biomedical applications by virtue of extraordinary properties including high fluorescence brightness, large absorption coefficients of one and two-photons, and excellent photostability and colloidal stability in water and physiological medium. In addition, low cytotoxicity, easy functionalization, and the ability to modify CPN photochemical properties by the incorporation of dopants, convert them into excellent theranostic agents with multifunctionality for imaging and treatment. In this work, CPNs were designed and synthesized by incorporating a metal oxide magnetic core (Fe3O4 and NiFe2O4 nanoparticles, 5 nm) into their matrix during the nanoprecipitation method. This modification allowed the in vivo monitoring of nanoparticles in animal models using magnetic resonance imaging (MRI) and intravital fluorescence, techniques widely used for intracranial tumors evaluation. The modified CPNs were assessed in vivo in glioblastoma (GBM) bearing mice, both heterotopic and orthotopic developed models. Biodistribution studies were performed with MRI acquisitions and fluorescence images up to 24 h after the i.v. nanoparticles administration. The resulting IONP-doped CPNs were biocompatible in GBM tumor cells in vitro with an excellent cell incorporation depending on nanoparticle concentration exposure. IONP-doped CPNs were detected in tumor and excretory organs of the heterotopic GBM model after i.v. and i.t. injection. However, in the orthotopic GBM model, the size of the nanoparticles is probably hindering a higher effect on intratumorally T2-weighted images (T2WI) signals and T2 values. The photodynamic therapy (PDT)—cytotoxicity of CPNs was not either affected by the IONPs incorporation into the nanoparticles.

scholarly journals In Vitro and in Vivo mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles

2011 ◽  
Vol 8 (3) ◽  
pp. 774-787 ◽  
Author(s):  
Xingfang Su ◽  
Jennifer Fricke ◽  
Daniel G. Kavanagh ◽  
Darrell J. Irvine
Keyword(s):  
Polymer Nanoparticles ◽  
Ph Responsive ◽  
Responsive Polymer

Second Near-Infrared Photoactivatable Biocompatible Polymer Nanoparticles for Effective in Vitro and in Vivo Cancer Theranostics

Nanoscale ◽  
2021 ◽  
Author(s):  
Fei Wang ◽  
Xiaoju Men ◽  
Haobin Chen ◽  
Feixue Mi ◽  
Mengze Xu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Tissue Penetration ◽  
Biocompatible Polymer ◽  
Cancer Theranostics ◽  
Maximum Permissible Exposure

Photoacoustic imaging (PAI)-guided photothermal therapy (PTT) has drawn considerable attention due to the deeper tissue penetration and higher maximum permissible exposure. However, current phototheranostic agents are greatly restricted to the...

Red Fluorescent Emissive Gd-Phenolic Nanoparticles for In Vivo Fluorescence and Magnetic Resonance Bimodal Imaging

2021 ◽  
Vol 17 (8) ◽  
pp. 1635-1646
Author(s):  
Weibing Xu ◽  
Jia Zhang ◽  
Minzhi Zhao ◽  
Zhijie Yang ◽  
Qingfeng Wu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Metabolic Pathways ◽  
Polymer Nanoparticles ◽  
Resonance Imaging ◽  
Dual Mode ◽  
Bimodal Imaging ◽  
Imaging Performance

Due to the combination of the high resolution of fluorescence imaging and the no limitation in penetration depth of magnetic resonance imaging, dual-mode imaging of magnetic resonance and fluorescence (MR/FI) have attracted extensive research in recent years. Herein, a novel MR/FI bimodal imaging probe is facile fabricated by attaching the rhodamine fluorophore covalently to the surface of the Gd-phenolic coordination polymer nanoparticles. The contents of Gd3+ and RB of the as prepared probe are calculated to be 8.2% and 12.5%. The quantum yield of the probe is about 8.84% as well as red fluorescent emissive. The longitudinal r1 value is 6.94 mM−1 s−1 and the ratio r2/r1 is very low and about 1.22. Subsequently, the and MR imaging and fluorescence both in vitro and In Vivo are performed. The metabolic pathways In Vivo are inferred by studying the bio-distribution of the probe in major organs. The as-prepared probe exhibits excellent imaging performance and biocompatibility, which is conducive to its further application.

Induction and Differentiation of Dental Epithelium in Vivo and in Vitro

1982 ◽  
Vol 40 ◽  
pp. 142-145
Author(s):  
E. J. Kollar
Keyword(s):  
Connective Tissue ◽  
Oral Mucosa ◽  
Basal Lamina ◽  
Functional Derivatives ◽  
Specific Source ◽  
Dental Epithelium ◽  
Connective Tissue Stroma

The differentiation and maintenance of many specialized epithelial structures are dependent on the underlying connective tissue stroma and on an intact basal lamina. These requirements are especially stringent in the development and maintenance of the skin and oral mucosa. The keratinization patterns of thin or thick cornified layers as well as the appearance of specialized functional derivatives such as hair and teeth can be correlated with the specific source of stroma which supports these differentiated expressions.

Ultrastructural Correlations between Clonal Human Tumor Colonies and in Vivo Neoplasms

1982 ◽  
Vol 40 ◽  
pp. 210-211
Author(s):  
M.J. Murphy ◽  
R.R. Price ◽  
J.C. Sloman
Keyword(s):  
Cultured Cells ◽  
Human Tumor ◽  
Cell Type ◽  
Tumor Mass ◽  
Initial Cell ◽  
Cloning Assay ◽  
Human Tumor Cloning ◽  
The Relationship

The in vitro human tumor cloning assay originally described by Salmon and Hamburger has been applied recently to the investigation of differential anti-tumor drug sensitivities over a broad range of human neoplasms. A major problem in the acceptance of this technique has been the question of the relationship between the cultured cells and the original patient tumor, i.e., whether the colonies that develop derive from the neoplasm or from some other cell type within the initial cell population. A study of the ultrastructural morphology of the cultured cells vs. patient tumor has therefore been undertaken to resolve this question. Direct correlation was assured by division of a common tumor mass at surgical resection, one biopsy being fixed for TEM studies, the second being rapidly transported to the laboratory for culture.

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