Molecular Mobility as an Effective Predictor of the Physical Stability of Amorphous Trehalose

2012 ◽  
Vol 9 (11) ◽  
pp. 3209-3217 ◽  
Author(s):  
Sunny P. Bhardwaj ◽  
Raj Suryanarayanan
Keyword(s):  
Molecular Mobility ◽  
Physical Stability

Correlation between Molecular Mobility and Physical Stability in Pharmaceutical Glasses

2016 ◽  
Vol 13 (4) ◽  
pp. 1267-1277 ◽  
Author(s):  
Mehak Mehta ◽  
Vishard Ragoonanan ◽  
Gregory B. McKenna ◽  
Raj Suryanarayanan
Keyword(s):  
Molecular Mobility ◽  
Physical Stability

scholarly journals Effect of Water on Molecular Mobility and Physical Stability of Amorphous Pharmaceuticals

2016 ◽  
Vol 13 (4) ◽  
pp. 1339-1346 ◽  
Author(s):  
Mehak Mehta ◽  
Khushboo Kothari ◽  
Vishard Ragoonanan ◽  
Raj Suryanarayanan
Keyword(s):  
Molecular Mobility ◽  
Physical Stability ◽  
Amorphous Pharmaceuticals ◽  
Effect Of Water

scholarly journals Applications of Dynamic Mechanical Analysis in the Engineering of Amorphous Solid Dispersions

2020 ◽  
Vol 02 (01) ◽  
pp. e55-e63
Author(s):  
Andrew Toye Ojo ◽  
Ping I. Lee
Keyword(s):  
Molecular Mobility ◽  
Solid Dispersions ◽  
Physical Stability ◽  
Amorphous Solid ◽  
Mechanical Analysis ◽  
Water Soluble ◽  
Amorphous Solid Dispersions ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

AbstractDynamic mechanical analysis (DMA) offers several advantages over prevailing methods in the characterization of amorphous solid dispersions (ASDs) typically used for improving the delivery of poorly water-soluble drugs. This method of analysis, though underutilized in the study of pharmaceutical systems, is particularly attuned to rheological investigations of thermal and mechanical properties of solids such as ASDs. Its ability to determine the viscoelastic properties of systems across a wide range of temperatures and shear conditions provides useful insight for the development and processing of ASDs. The response of materials to an imposed stress, captured by DMA, can help identify proper conditions for preparing homogenous extrudates of the polymer and active pharmaceutical ingredient through hot melt extrusion (HME). As HME continues to gain utility within the pharmaceutical industry, the ability to tailor process conditions will become increasingly important for the efficient design and production of ASD products for poorly water-soluble drugs. Furthermore, DMA can be used to probe molecular mobility and its link to physical stability of ASDs. Establishing the link between molecular mobility and crystallization kinetics is central to predicting the physical stability of ASDs. Therefore, increasing the understanding of material properties through DMA will enable the successful development of more stable amorphous drug products. This review summarizes current characterization tools for ASDs and discusses the potential of utilizing DMA as a robust alternative to traditional methods.

Physical Stability of Amorphous Pharmaceuticals: Importance of Configurational Thermodynamic Quantities and Molecular Mobility

2002 ◽  
Vol 91 (8) ◽  
pp. 1863-1872 ◽  
Author(s):  
Deliang Zhou ◽  
Geoff G.Z. Zhang ◽  
Devalina Law ◽  
David J.W. Grant ◽  
Eric A. Schmitt
Keyword(s):  
Molecular Mobility ◽  
Physical Stability ◽  
Thermodynamic Quantities ◽  
Amorphous Pharmaceuticals

Physical Stability of the Amorphous Anticholesterol Agent (Ezetimibe): The Role of Molecular Mobility

2014 ◽  
Vol 11 (11) ◽  
pp. 4280-4290 ◽  
Author(s):  
J. Knapik ◽  
Z. Wojnarowska ◽  
K. Grzybowska ◽  
L. Hawelek ◽  
W. Sawicki ◽  
...  
Keyword(s):  
Molecular Mobility ◽  
Physical Stability
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