Effects of pH and Polyanions on the Thermal Stability of Fibroblast Growth Factor 20

2007 ◽  
Vol 4 (2) ◽  
pp. 232-240 ◽  
Author(s):  
Haihong Fan ◽  
Samadhi N. Vitharana ◽  
Tracy Chen ◽  
Donald O'Keefe ◽  
C. Russell Middaugh
Keyword(s):  
Thermal Stability ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Effects Of Ph ◽  
Thermal Stability Of ◽  
Factor 20

Single-Dose Prevention or Short-Term Treatment with Fibroblast Growth Factor-20 (CG53135-05) Reduces the Severity and Duration of Oral Mucositis

2005 ◽  
Vol 2 (2) ◽  
pp. 122-127 ◽  
Author(s):  
Enrique Alvarez ◽  
Valerie L. Gerlach ◽  
Robert W. Gerwien ◽  
Edward G. Fey ◽  
Brynmor A. Watkins ◽  
...  
Keyword(s):  
Single Dose ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Oral Mucositis ◽  
Term Treatment ◽  
Fibroblast Growth ◽  
Short Term ◽  
Short Term Treatment ◽  
Factor 20

Human fibroblast growth factor 20 (FGF-20; CG53135-05): A novel cytoprotectant with radioprotective potential

2005 ◽  
Vol 81 (8) ◽  
pp. 567-579 ◽  
Author(s):  
T. Maclachlan ◽  
B. Narayanan ◽  
V. L. Gerlach ◽  
G. Smithson ◽  
R. W. Gerwien ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Human Fibroblast ◽  
Fibroblast Growth ◽  
Factor 20

scholarly journals The Effect of MSCs Derived from the Human Umbilical Cord Transduced by Fibroblast Growth Factor-20 on Parkinson’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Li Jinfeng ◽  
Wang Yunliang ◽  
Liu Xinshan ◽  
Wang Shanshan ◽  
Xu Chunyang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Growth Factor ◽  
Cell Therapy ◽  
Fibroblast Growth Factor ◽  
Umbilical Cord ◽  
Human Umbilical Cord ◽  
Fibroblast Growth ◽  
Mice Model ◽  
Factor 20

Cell therapy is a potential therapeutic approach for Parkinson’s disease (PD). Mesenchymal stem cells derived from the human umbilical cord (hUC-MSCs) give priority to PD patients because of multiple advantages. The appropriate gene transduction of hUC-MSC before transplantation is a promising procedure for cell therapy. Fibroblast growth factor-20 (FGF-20) has been shown to protect dopaminergic neurons against a range of toxic insults in vitro. In this study, the hUC-MSCs were gene transduced with FGF-20, and then we transplanted them into the PD mice model. The results showed that MSC-FGF-20 treatment obviously improved the behavior of PD, accompanied by the increase of tyrosine carboxylase- (TH-) positive cell and dopamine (DA). Furtherly, immunohistochemistry disclosed that MSC-FGF-20 obviously promoted the degradation of nuclear factor-κB (NF-κB), a transcription factor that controls genes encoding proinflammatory cytokines, highly expressed in the nigrostriatal dopaminergic regions in PD patients. Therefore, MSC-FGF-20 has a potential for improving PD, closely related to the degradation of NF-κB.

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