scholarly journals Poly(ethylene oxide)-Modified Poly(β-amino ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs. 1. In Vitro Evaluations

2005 ◽  
Vol 2 (5) ◽  
pp. 357-366 ◽  
Author(s):  
Dinesh Shenoy ◽  
Steven Little ◽  
Robert Langer ◽  
Mansoor Amiji
Keyword(s):  
Ethylene Oxide ◽  
Targeted Delivery ◽  
Ph Sensitive ◽  
Amino Ester ◽  
Hydrophobic Drugs ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

scholarly journals Drug Delivery System Based on pH-Sensitive Biocompatible Poly(2-vinyl pyridine)-b-poly(ethylene oxide) Nanomicelles Loaded with Curcumin and 5-Fluorouracil

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1450 ◽  
Author(s):  
Camelia-Elena Iurciuc-Tincu ◽  
Monica Stamate Cretan ◽  
Violeta Purcar ◽  
Marcel Popa ◽  
Oana Maria Daraba ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Ethylene Oxide ◽  
Ph Sensitive ◽  
Hydrophobic Drugs ◽  
Practical Utilization ◽  
Vinyl Pyridine ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Smart polymeric micelles (PMs) are of practical interest as nanocarriers for the encapsulation and controlled release of hydrophobic drugs. Two hydrophobic drugs, naturally-based curcumin (Cur) and synthetic 5-fluorouracil (5-FU), were loaded into the PMs formed by a well-defined pH-sensitive poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP90-b-PEO398) block copolymer. The influence of the drug loading on the micellar sizes was investigated by dynamic light scattering (DLS) and it appears that the size of the PMs increases from around 60 to 100 nm when Cur is loaded. On the contrary, the loading of the 5-FU has a smaller effect on the micellar sizes. This difference can be attributed to higher molar mass of Cur with respect to 5-FU but also to higher loading efficiency of Cur, 6.4%, compared to that of 5-FU, 5.8%. In vitro drug release was studied at pH 2, 6.8, and 7.4, and it was observed that the pH controls the release of both drugs. At pH 2, where the P2VP sequences from the “frozen-in” micellar core are protonated, the drug release efficiencies exceed 90%. Moreover, it was demonstrated, by in vitro assays, that these PMs are hemocompatible and biocompatible. Furthermore, the PMs protect the Cur against the photo-degradation, whereas the non-ionic PEO corona limits the adsorption of bovine serum albumin (BSA) protein on the surface. This study demonstrates that these pH-sensitive PMs are suitable for practical utilization as human-safe and smart, injectable drug delivery systems.

Micellization of pH-sensitive poly(butadiene)-block -poly(2 vinylpyridine)-block -poly(ethylene oxide) triblock copolymers: Complex formation with anionic surfactants

2017 ◽  
Vol 134 (38) ◽  
pp. 45313 ◽  
Author(s):  
Leonard Ionut Atanase ◽  
Jean-Philippe Lerch ◽  
Simona Caprarescu ◽  
Camelia Elena Iurciuc Tincu ◽  
Gerard Riess
Keyword(s):  
Complex Formation ◽  
Ethylene Oxide ◽  
Anionic Surfactants ◽  
Triblock Copolymers ◽  
Ph Sensitive ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Surface Modification of Copolyether-Urethane Catheters with Poly(Ethylene Oxide)

1989 ◽  
Vol 12 (6) ◽  
pp. 390-394 ◽  
Author(s):  
E. Brinkman ◽  
A. Poot ◽  
T. Beugeling ◽  
L. Van Der Does ◽  
A. Bantjes
Keyword(s):  
Surface Modification ◽  
Ethylene Oxide ◽  
Blood Compatibility ◽  
Angle Measurements ◽  
Fold Reduction ◽  
Contact Angle Measurements ◽  
Platelet Deposition ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Pellethane 2363 80A catheters were modified with poly(ethylene oxide) in order to improve their blood compatibility. Contact angle measurements showed that Pellethane 2363 80A surfaces had increased wettability after this modification. The results of in vitro blood compatibility tests showed that surface modification with poly(ethylene oxide) resulted in a five-fold reduction of platelet deposition. Activation of coagulation was not affected.

Fabrication of electrospun poly(ethylene oxide)–poly(capro lactone) composite nanofibers for co-delivery of niclosamide and silver nanoparticles exhibits enhanced anti-cancer effects in vitro

2016 ◽  
Vol 4 (4) ◽  
pp. 726-742 ◽  
Author(s):  
Poornima Dubey ◽  
P. Gopinath
Keyword(s):  
Silver Nanoparticles ◽  
Ethylene Oxide ◽  
Anticancer Drugs ◽  
Composite Nanofibers ◽  
Water Solubility ◽  
Intrinsic Property ◽  
Anti Cancer ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

An intrinsic property of many anticancer drugs including niclosamide is poor water solubility, which hindered their translation from laboratory to clinics.

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