Fabrication of electrospun poly(ethylene oxide)–poly(capro lactone) composite nanofibers for co-delivery of niclosamide and silver nanoparticles exhibits enhanced anti-cancer effects in vitro

2016 ◽  
Vol 4 (4) ◽  
pp. 726-742 ◽  
Author(s):  
Poornima Dubey ◽  
P. Gopinath
Keyword(s):  
Silver Nanoparticles ◽  
Ethylene Oxide ◽  
Anticancer Drugs ◽  
Composite Nanofibers ◽  
Water Solubility ◽  
Intrinsic Property ◽  
Anti Cancer ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

An intrinsic property of many anticancer drugs including niclosamide is poor water solubility, which hindered their translation from laboratory to clinics.

scholarly journals Development of Self-Associating SN-38-Conjugated Poly(ethylene oxide)-Poly(ester) Micelles for Colorectal Cancer Therapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1033
Author(s):  
Sams M. A. Sadat ◽  
Mohammad Reza Vakili ◽  
Igor M. Paiva ◽  
Michael Weinfeld ◽  
Afsaneh Lavasanifar
Keyword(s):  
Colorectal Cancer ◽  
Ethylene Oxide ◽  
Water Solubility ◽  
In Vitro Release ◽  
Critical Micellar Concentration ◽  
Anticancer Activities ◽  
Poly Ethylene Oxide ◽  
Self Assembled ◽  
Poly Ethylene

The clinical use of 7-ethyl-10-hydroxy-camptothecin (SN-38), which is the active metabolite of irinotecan, has been hampered because of its practical water-insolubility. In this study, we successfully synthesized two self-associating SN-38-polymer drug conjugates to improve the water-solubility of SN-38, while retaining its anticancer activity. The polymeric micellar SN-38 conjugates were composed of either methoxy-poly(ethylene oxide)-block-poly(α-benzyl carboxylate-ε-caprolactone) conjugated to SN-38 at the PBCL end (mPEO-b-PBCL/SN-38) or mPEO-block-poly(α-carboxyl-ε-caprolactone) attached to SN-38 from the pendent-free carboxyl site (mPEO-b-PCCL/SN-38). The chemical structure of block copolymers was confirmed by 1H NMR. The physicochemical characterizations of their self-assembled structures including size, surface charge, polydispersity, critical micellar concentration, conjugation content and efficiency, morphology, kinetic stability, and in vitro release of SN-38 were compared between the two formulations. In vitro anticancer activities were evaluated by measuring cellular cytotoxicity and caspase activation by MTS and Caspase-Glo 3/7 assays, respectively. The hemolytic activity of both micellar structures against rat red blood cells was also measured. The results showed the formation of SN-38-polymeric micellar conjugates at diameters < 50 nm with a narrow size distribution and sustained release of SN-38 for both structures. The loading content of SN-38 in mPEO-b-PBCL and mPEO-b-PCCL were 11.47 ± 0.10 and 12.03 ± 0.17 (% w/w), respectively. The mPEO-b-PBCL/SN-38, end-capped micelles were kinetically more stable than mPEO-b-PCCL/SN-38. The self-assembled mPEO-b-PBCL/SN-38 and mPEO-b-PCCL/SN-38 micelles resulted in significantly higher cytotoxic effects than irinotecan against human colorectal cancer cell lines HCT116, HT-29, and SW20. The CRC cells were found to be 70-fold to 330-fold more sensitive to micellar SN-38 than irinotecan, on average. Both SN-38-incorporated micelles showed two-fold higher caspase-3/7 activation levels than irinotecan. The mPEO-b-PBCL/SN-38 micelles were not hemolytic, but mPEO-b-PCCL/SN-38 showed some hemolysis. The overall results from this study uphold mPEO-b-PBCL/SN-38 over mPEO-b-PCCL/SN-38 micellar formulation as an effective delivery system of SN-38 that warrants further preclinical investigation.

scholarly journals Electrospun Silver Nanoparticles-Embedded Feather Keratin/Poly(vinyl alcohol)/Poly(ethylene oxide) Antibacterial Composite Nanofibers

Polymers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 305 ◽  
Author(s):  
Ming He ◽  
Man Chen ◽  
Yao Dou ◽  
Jiao Ding ◽  
Hangbo Yue ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Ethylene Oxide ◽  
Vinyl Alcohol ◽  
Composite Nanofibers ◽  
Poly Vinyl Alcohol ◽  
Feather Keratin ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Feathers, which contain >90% keratin, are valuable natural protein resources. The aim of this study is to prepare antimicrobial feather keratin (FK)-based nanofibers by incorporating silver nanoparticles (AgNPs). A series of AgNPs-embedded feather keratin/poly(vinyl alcohol)/poly(ethylene oxide) (FK/PVA/PEO) composite nanofibers with varying amounts of AgNPs content were fabricated by electrospinning. Their morphology, crystallinity, thermal stability, tensile property, and antibacterial activity were systematically investigated. The average diameters of composite nanofibers gradually decreased with increases in the amount of AgNPs. The crystallinity, thermal stability, and antibacterial activity of FK/PVA/PEO nanofibers were enhanced by embedding AgNPs. When embedded with 1.2% AgNPs, both the tensile strength and elongation-at-break reached the highest level. This work has the potential to expand the application of FK-based nanofibers in the biomaterial field.

Surface Modification of Copolyether-Urethane Catheters with Poly(Ethylene Oxide)

1989 ◽  
Vol 12 (6) ◽  
pp. 390-394 ◽  
Author(s):  
E. Brinkman ◽  
A. Poot ◽  
T. Beugeling ◽  
L. Van Der Does ◽  
A. Bantjes
Keyword(s):  
Surface Modification ◽  
Ethylene Oxide ◽  
Blood Compatibility ◽  
Angle Measurements ◽  
Fold Reduction ◽  
Contact Angle Measurements ◽  
Platelet Deposition ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Pellethane 2363 80A catheters were modified with poly(ethylene oxide) in order to improve their blood compatibility. Contact angle measurements showed that Pellethane 2363 80A surfaces had increased wettability after this modification. The results of in vitro blood compatibility tests showed that surface modification with poly(ethylene oxide) resulted in a five-fold reduction of platelet deposition. Activation of coagulation was not affected.

Adsorption of hexavalent chromium by novel chitosan/poly(ethylene oxide)/permutit electrospun nanofibers

2018 ◽  
Vol 42 (21) ◽  
pp. 17740-17749 ◽  
Author(s):  
Panpan Wang ◽  
Lihua Wang ◽  
Shujun Dong ◽  
Guohui Zhang ◽  
Xuejuan Shi ◽  
...  
Keyword(s):  
Ion Exchange ◽  
Ethylene Oxide ◽  
Hexavalent Chromium ◽  
Electrostatic Interaction ◽  
Composite Nanofibers ◽  
Adsorption Mechanism ◽  
Electrospun Nanofibers ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

The Cr(vi) adsorption mechanism by CS/PEO/PT composite nanofibers includes electrostatic interaction, chelation, reduction and ion exchange.

Influence of surface coverage with poly(ethylene oxide) on attachment of sterically stabilized microspheres to rat Kupffer cells in vitro

Biomaterials ◽  
1995 ◽  
Vol 16 (6) ◽  
pp. 427-439 ◽  
Author(s):  
Garry R. Harper ◽  
Stanley S. Davis ◽  
Martyn C. Davies ◽  
Maria E. Norman ◽  
Tharwat F. Tadros ◽  
...  
Keyword(s):  
Ethylene Oxide ◽  
Kupffer Cells ◽  
Surface Coverage ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

In vitro anticancer activity of docetaxel-loaded micelles based on poly(ethylene oxide)-poly(epsilon-caprolactone) block copolymers: Do nanocarrier properties have a role?

2010 ◽  
Vol 148 (2) ◽  
pp. 255-263 ◽  
Author(s):  
Luisanna Ostacolo ◽  
Monica Marra ◽  
Francesca Ungaro ◽  
Silvia Zappavigna ◽  
Giovanni Maglio ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Oxide ◽  
Anticancer Activity ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

One-step fabrication of antibacterial (silver nanoparticles/poly(ethylene oxide)) – Polyurethane bicomponent hybrid nanofibrous mat by dual-spinneret electrospinning

2012 ◽  
Vol 134 (2-3) ◽  
pp. 557-561 ◽  
Author(s):  
Leonard D. Tijing ◽  
Michael Tom G. Ruelo ◽  
Altangerel Amarjargal ◽  
Hem Raj Pant ◽  
Chan-Hee Park ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Ethylene Oxide ◽  
One Step ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene
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