scholarly journals Novel Hybrids of Natural Oridonin-Bearing Nitrogen Mustards as Potential Anticancer Drug Candidates

2014 ◽  
Vol 5 (7) ◽  
pp. 797-802 ◽  
Author(s):  
Shengtao Xu ◽  
Lingling Pei ◽  
Chengqian Wang ◽  
Yun-Kai Zhang ◽  
Dahong Li ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Nitrogen Mustards ◽  
Drug Candidates

Molecular Topological Properties of Alkylating Agents Based Anticancer Drug Candidates Via Some Ve-degree Topological Indices

2020 ◽  
Vol 16 (2) ◽  
pp. 190-195 ◽  
Author(s):  
Süleyman Ediz ◽  
Murat Cancan
Keyword(s):  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Alkylating Agents ◽  
Topological Indices ◽  
Pharmacological Properties ◽  
Topological Properties ◽  
Drug Candidates ◽  
New Drug ◽  
Atom Bond ◽  
Dual Target

Background: Reckoning molecular topological indices of drug structures gives the data about the underlying topology of these drug structures. Novel anticancer drugs have been leading by researchers to produce ideal drugs. Materials and Methods: Pharmacological properties of these new drug agents explored by utilizing simulation strategies. Topological indices additionally have been utilized to research pharmacological properties of some drug structures. Novel alkylating agents based anticancer drug candidates and ve-degree molecular topological indices have been introduced recently. Results and Conclusion: In this study we calculate ve-degree atom-bond connectivity, harmonic, geometric-arithmetic and sum-connectivity molecular topological indices for the newly defined alkylating agents based dual-target anticancer drug candidates.

CZE–ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP

2008 ◽  
Vol 102 (5-6) ◽  
pp. 1060-1065 ◽  
Author(s):  
Michael Groessl ◽  
Christian G. Hartinger ◽  
Paul J. Dyson ◽  
Bernhard K. Keppler
Keyword(s):  
Anticancer Drug ◽  
Model Compound ◽  
Drug Candidates ◽  
Icp Ms ◽  
Hydrolysis Of

In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR

2016 ◽  
Vol 14 (2) ◽  
pp. 125-134 ◽  
Author(s):  
Wolfgang Walther ◽  
Oyinlola Dada ◽  
Cillian O’Beirne ◽  
Ingo Ott ◽  
Goar Sánchez-Sanz ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Gold Chloride ◽  
Drug Candidates

Development and Advances of Drugs for Cancer Theranostics – PART-IV

2021 ◽  
Vol 21 (18) ◽  
pp. 1644-1644
Author(s):  
Lian-Shun Feng
Keyword(s):  
Drug Discovery ◽  
Side Effects ◽  
Anticancer Activity ◽  
Anticancer Drug ◽  
Anticancer Agents ◽  
Drug Repurposing ◽  
Biological Properties ◽  
Drug Candidates ◽  
Pharmacokinetic Profiles ◽  
Hybrid Molecules

Cancer, a highly heterogeneous disease at intra/inter patient levels, is one of the most serious threats to human health across the world [1, 2]. Notwithstanding the noteworthy advances in its treat-ment, the morbidity and mortality of cancer are projected to grow for a long period, and the global cancer burden is expected to be 28.4 million cases in 2040, a 47% rise from 2020 [3]. Accordingly, there is a constant need to explore novel anticancer agents. <p> There are several strategies to discover novel anticancer candidates: (1) new lead hits or candidates from natural resources [4] whichexhibit various biological properties and are a rich source of com-pounds in drug discovery due to the structural and mechanistic diversity, and more than 60% anti-cancer agents can be traced to a natural product; (2) Molecular hybridization is one of the most prom-ising strategies for the discovery of novel anticancer drug candidates since hybrid molecules have the potential to bind multiple targets or to enhance the effect through acting with another bio-target or to counterbalance the side effects caused by the other part of the hybrid [5]; (3) Dimerization is a useful tool to develop novel anticancer drug candidates with enhanced biological activity, reduced side effects and improved pharmacokinetic profiles [6]; (4) Drug repurposing strategy is is an attractive strategy and has been approved, along with non-anticancer macrolide drugs for the treatment of cancer, for anticancer drug discovery since toxicity and pharmacokinetic profiles have already been estab-lished [7]. <p> Heterocycles coumarin, β-lactone, macrolide and triazole are useful anticancer pharmacophores since their derivatives could exert the anticancer activity through diverse mechanisms, inclusive of inhibition of aromatase, carbonic anhydrase, ki-nase, P-glycoprotein, sulfatase, telomerase, vascular endothelial growth factor receptor 2 and tubulin [8-11]. In particular, nat-ural-derived coumarin, β-lactone and macrolide derivatives are important sources of new anticancer lead hits/candidates; mac-rolide repurposed drugs can circumvent high cost and long-time associated with traditional drug discovery strategies; couma-rin, β-lactone and macrolide hybrids as well as bis-triazole compounds have the potential to enhance the anticancer activity, overcome drug resistance, reduce the side effects and improve pharmacokinetic profiles.

scholarly journals Atypical Lone Pair–π Interaction with Quinone Methides in a Series of Imido‐Ferrociphenol Anticancer Drug Candidates

2019 ◽  
Author(s):  
Yong Wang ◽  
Pascal Pigeon ◽  
Siden Top ◽  
Juan Sanz García ◽  
Claire Troufflard ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Lone Pair ◽  
Quinone Methides ◽  
Drug Candidates

Marine steroids as potential anticancer drug candidates: In silico investigation in search of inhibitors of Bcl-2 and CDK-4/Cyclin D1

Steroids ◽  
2015 ◽  
Vol 102 ◽  
pp. 7-16 ◽  
Author(s):  
Surovi Saikia ◽  
Bhaskor Kolita ◽  
Partha P. Dutta ◽  
Deep J. Dutta ◽  
Neipihoi ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Anticancer Drug ◽  
In Silico ◽  
Drug Candidates

Ferrocenes as new anticancer drug candidates: Determination of the mechanism of action

2020 ◽  
Vol 867 ◽  
pp. 172825 ◽  
Author(s):  
Hana Skoupilova ◽  
Martin Bartosik ◽  
Lucia Sommerova ◽  
Jiri Pinkas ◽  
Tomas Vaculovic ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Mechanism Of Action ◽  
Drug Candidates
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