scholarly journals Synthesis of 2α-Heteroarylalkyl Active Vitamin D3 with Therapeutic Effect on Enhancing Bone Mineral Density in Vivo

2013 ◽  
Vol 4 (7) ◽  
pp. 671-674 ◽  
Author(s):  
Miki Matsuo ◽  
Asami Hasegawa ◽  
Masashi Takano ◽  
Hiroshi Saito ◽  
Shinji Kakuda ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Therapeutic Effect ◽  
Bone Mineral ◽  
Vitamin D3 ◽  
Active Vitamin ◽  
Mineral Density

Effect of active vitamin D3 on reduction in Bone Mineral Density after oophorectomy

1992 ◽  
Vol 17 ◽  
pp. 183
Author(s):  
Y. Seimiya ◽  
J-T. Chen ◽  
Y. Hirai ◽  
M. Shiraki
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Vitamin D3 ◽  
Active Vitamin ◽  
Mineral Density

The effects of ovariectomy on bone mineral density, geometrical, and biomechanical characteristics in the rabbit femur

2010 ◽  
Vol 23 (01) ◽  
pp. 31-36 ◽  
Author(s):  
M. E. Kara ◽  
F. Sevil
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Animal Studies ◽  
Biomechanical Properties ◽  
Mineral Density ◽  
Cross Sectional ◽  
Tomographic Images ◽  
Three Point Bending ◽  
Rabbit Femur

SummaryThe aim of the study was to evaluate the bone mineral density, as well as the biomechanic and morphometric changes in the femur of ovariectomised rabbits.Twenty-four six-month-old New Zealand rabbits were randomly divided into an ovariectomy (n = 12) and a sham (n = 12) group. Six rabbits in each group were euthanatized at eight and 16 weeks after surgery, and the femora were resected. The morphometric data were obtained from tomographic images. Periosteal and endosteal diameters and cortical thickness were measured. Total cross-sectional, cortical and medullary areas were also measured. The bone mineral content, the bone area and the bone mineral density were measured from the proximal, distal and mid-shaft of the femur as well as the total femur by dual energy X-ray absorptiometry. Employing the three-point bending method, the ultimate force, stiffness and work-to-failure were measured. The mechanical data were normalised to obtain intrinsic biomechanical properties such as ultimate stress, elastic modulus, and toughness, all of which are independent of size and shape.The results indicated that the femur was both larger and weaker 16 weeks after surgery in the ovariectomised group. Results also suggest that the rabbit might be a useful animal model for investigation of diseases related to oestrogen loss such as human postmenopausal osteoporosis. However, additional studies with advanced techniques at several time points via in vivo animal studies, and precision and predictability analyses should be designed to standardise the rabbit as a model for osteoporosis.

scholarly journals Assessing bone mineral density in vivo: digitized fluoroscopy and ultrasound

2004 ◽  
Vol 83 (2) ◽  
pp. 207-214 ◽  
Author(s):  
R.H. Fleming ◽  
D. Korver ◽  
H.A. McCormack ◽  
C.C. Whitehead
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density
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