scholarly journals Ring Structure and Aromatic Substituent Effects on the pKa of the Benzoxaborole Pharmacophore

2011 ◽  
Vol 3 (1) ◽  
pp. 48-52 ◽  
Author(s):  
John W. Tomsho ◽  
Arnab Pal ◽  
Dennis G. Hall ◽  
Stephen J. Benkovic
Keyword(s):  
Substituent Effects ◽  
Ring Structure ◽  
Aromatic Substituent

Substituent effects in naphthalene. II. The strengths of the 4, 5, 6, 7, and 8-substituted 2-naphthoic acids

1965 ◽  
Vol 18 (9) ◽  
pp. 1365 ◽  
Author(s):  
PR Wells ◽  
W Adcock
Keyword(s):  
Electrostatic Interactions ◽  
Aqueous Ethanol ◽  
Substituent Effects ◽  
Simple Expression ◽  
Dipole Orientation ◽  
Aromatic Substituent ◽  
Resonance Effects ◽  
Naphthoic Acid ◽  
Inductive Effects ◽  
Substituted 1

The apparent pKa values of 44 substituted 2-naphthoic acids, six substituted 1-naphthoic acids, and the unsubstituted naphthoic acids have been determined for 50% v/v aqueous ethanol at 25�. The ΔpK values are examined in terms of Dewar and Grisdale's simple expression for aromatic substituent effects. This expression proves to be fairly satisfactory, but takes no account of substituent dipole orientation, secondary resonance effects, nor π-inductive effects. A survey of the naphthoic acid strengths demonstrates the importance of these factors. In particular, unambiguous evidence for the important role played by direct electrostatic interactions is obtained.

Aromatic substituent effects in palladium-catalyzed intramolecular olefin oxyarylation reactions

2020 ◽  
Vol 61 (13) ◽  
pp. 151674
Author(s):  
Mark C. Maust ◽  
Zacary L. Croft ◽  
Mackenzie W. Sullivan ◽  
Ross L. Dove ◽  
Emily E. Hardy ◽  
...  
Keyword(s):  
Substituent Effects ◽  
Aromatic Substituent ◽  
Palladium Catalyzed

ChemInform Abstract: Synthesis of Vinca Alkaloids and Related Compounds. Part 49. Aromatic Substituent Effects in the C-14 Epimerization.

ChemInform ◽  
2010 ◽  
Vol 22 (33) ◽  
pp. no-no
Author(s):  
I. MOLDVAI ◽  
A. VEDRES ◽  
C. JUN. SZANTAY ◽  
G. TOTH ◽  
C. SZANTAY
Keyword(s):  
Substituent Effects ◽  
Vinca Alkaloids ◽  
Aromatic Substituent ◽  
Related Compounds

Aromatic Substituent Effects on the Flexibility of Metal–Organic Frameworks

2016 ◽  
Vol 55 (15) ◽  
pp. 7576-7581 ◽  
Author(s):  
Hyungwoo Hahm ◽  
Kwangho Yoo ◽  
Hyeonbin Ha ◽  
Min Kim
Keyword(s):  
Metal Organic Frameworks ◽  
Substituent Effects ◽  
Aromatic Substituent ◽  
Metal Organic

Solvent Modulation of Aromatic Substituent Effects in Molecular Balances Controlled by CH−π Interactions

2018 ◽  
Vol 122 (4) ◽  
pp. 909-915 ◽  
Author(s):  
Bright U. Emenike ◽  
Ronald A. Spinelle ◽  
Ambar Rosario ◽  
David W. Shinn ◽  
Barney Yoo
Keyword(s):  
Substituent Effects ◽  
Aromatic Substituent ◽  
Π Interactions
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