Synthesis and Thermoresponsive Solution Properties of Poly[oligo(ethylene glycol) (meth)acrylamide]s: Biocompatible PEG Analogues

2012 ◽  
Vol 45 (3) ◽  
pp. 1362-1374 ◽  
Author(s):  
Giles B. H. Chua ◽  
Peter J. Roth ◽  
Hien T. T. Duong ◽  
Thomas P. Davis ◽  
Andrew B. Lowe
Keyword(s):  
Ethylene Glycol ◽  
Solution Properties

Short oligo(ethylene glycol) chain incorporated thermoresponsive microgels: from structural analysis to modulation of solution properties

Soft Matter ◽  
2020 ◽  
Vol 16 (33) ◽  
pp. 7845-7859
Author(s):  
Priyanshi Agnihotri ◽  
Ritu Raj ◽  
Dinesh Kumar ◽  
Abhijit Dan
Keyword(s):  
Structural Analysis ◽  
Ethylene Glycol ◽  
Aqueous Medium ◽  
Solution Properties ◽  
Glycol Methacrylate ◽  
Colloidal Properties

This work reports the synthesis, structural analysis and colloidal properties in aqueous medium of thermoresponsive PNIPAM-based microgels incorporating short oligo(ethylene glycol) methacrylate comonomers.

One-shot synthesis and solution properties of ROS/pH responsive methoxy poly(ethylene glycol)-b-polycarbonate

2019 ◽  
Vol 10 (17) ◽  
pp. 2143-2151 ◽  
Author(s):  
Yan Zhang ◽  
Yue Xu ◽  
Chao Wei ◽  
Chuanhao Sun ◽  
Bingkun Yan ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Tertiary Amine ◽  
Solution Properties ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Amine Groups ◽  
Poly Ethylene

A one-shot method was employed to synthesize ROS/pH responsive methoxy poly(ethylene glycol)-b-polycarbonate (mPEG-b-poly(MN-co-MSe)) with the selenide and tertiary amine groups situated on the backbone.

scholarly journals Influence of the chemistry of conjugation of poly(ethylene glycol) to Hb on the oxygen-binding and solution properties of the PEG-Hb conjugate

2005 ◽  
Vol 392 (3) ◽  
pp. 555-564 ◽  
Author(s):  
Tao Hu ◽  
Muthuchidambaram Prabhakaran ◽  
Seetharama A. Acharya ◽  
Belur N. Manjula
Keyword(s):  
Ethylene Glycol ◽  
Direct Consequence ◽  
Oxygen Binding ◽  
Solution Properties ◽  
Reductive Alkylation ◽  
Poly Ethylene Glycol ◽  
Protein Mass ◽  
Allosteric Effectors ◽  
Surface Decoration ◽  
Poly Ethylene

Our recent studies on PEG–Hb [poly(ethylene glycol)–Hb] conjugates generated by thiolation-mediated maleimide-chemistry based PEGylation demonstrated that the vasoactivity of the PEG–Hb conjugates is a function of the configuration of the PEG chains on the surface of the protein and is independent of the PEG/protein-mass ratio [Manjula, A. G. Tsai, Intaglietta, H.-C. Tsai, Ho, Smith, Perumalsamy, Kanika, Friedman and Acharya (2005) Protein J. 24, 133–146]. A Hb conjugated with six PEG5k chains (SP-PEG5k)6-Hb, was vasoinactive. In an attempt to understand whether the chemistry of conjugation of PEG to Hb has any influence on the modulation of its functional and solution properties, we have now generated a new hexaPEGylated-Hb, (propyl-PEG5k)6-Hb, by reductive alkylation chemistry. CD (circular dichroism) spectral measurements indicated that the overall secondary structure of Hb is not adversely influenced upon PEGylation. (Propyl-PEG5k)6-Hb exhibited an increased O2 affinity with decreased co-operativity and decreased modulation by allosteric effectors comparable with that of (SP-PEG5k)6-Hb, although its Cys-93(β) is not derivatized as in the latter. On a molecular mass basis, PEG linked to Hb by reductive alkylation increased its COP (colloidal osmotic pressure) more efficiently than when linked by thiolation-mediated maleimide-chemistry. These results demonstrate that the functional properties of PEG–Hb conjugates may be a direct consequence of surface decoration of Hb with PEG, but are independent of the site (pattern) and/or the chemistry of PEGylation. However the solution properties of PEGylated Hb are influenced by the site (pattern) and/or the chemistry of PEGylation and the presence or absence of an ‘extension arm’ between the conjugating site of Hb and the PEG chain.

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