Synthesis and aqueous solution properties of aliphatic double chain end-capped poly(ethylene glycol)

2001 ◽  
Vol 46 (6) ◽  
pp. 471-478 ◽  
Author(s):  
S. Rangelov ◽  
Ch. Tsvetanov
Keyword(s):  
Aqueous Solution ◽  
Ethylene Glycol ◽  
Solution Properties ◽  
Poly Ethylene Glycol ◽  
Double Chain ◽  
Poly Ethylene

One-shot synthesis and solution properties of ROS/pH responsive methoxy poly(ethylene glycol)-b-polycarbonate

2019 ◽  
Vol 10 (17) ◽  
pp. 2143-2151 ◽  
Author(s):  
Yan Zhang ◽  
Yue Xu ◽  
Chao Wei ◽  
Chuanhao Sun ◽  
Bingkun Yan ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Tertiary Amine ◽  
Solution Properties ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Amine Groups ◽  
Poly Ethylene

A one-shot method was employed to synthesize ROS/pH responsive methoxy poly(ethylene glycol)-b-polycarbonate (mPEG-b-poly(MN-co-MSe)) with the selenide and tertiary amine groups situated on the backbone.

scholarly journals Influence of the chemistry of conjugation of poly(ethylene glycol) to Hb on the oxygen-binding and solution properties of the PEG-Hb conjugate

2005 ◽  
Vol 392 (3) ◽  
pp. 555-564 ◽  
Author(s):  
Tao Hu ◽  
Muthuchidambaram Prabhakaran ◽  
Seetharama A. Acharya ◽  
Belur N. Manjula
Keyword(s):  
Ethylene Glycol ◽  
Direct Consequence ◽  
Oxygen Binding ◽  
Solution Properties ◽  
Reductive Alkylation ◽  
Poly Ethylene Glycol ◽  
Protein Mass ◽  
Allosteric Effectors ◽  
Surface Decoration ◽  
Poly Ethylene

Our recent studies on PEG–Hb [poly(ethylene glycol)–Hb] conjugates generated by thiolation-mediated maleimide-chemistry based PEGylation demonstrated that the vasoactivity of the PEG–Hb conjugates is a function of the configuration of the PEG chains on the surface of the protein and is independent of the PEG/protein-mass ratio [Manjula, A. G. Tsai, Intaglietta, H.-C. Tsai, Ho, Smith, Perumalsamy, Kanika, Friedman and Acharya (2005) Protein J. 24, 133–146]. A Hb conjugated with six PEG5k chains (SP-PEG5k)6-Hb, was vasoinactive. In an attempt to understand whether the chemistry of conjugation of PEG to Hb has any influence on the modulation of its functional and solution properties, we have now generated a new hexaPEGylated-Hb, (propyl-PEG5k)6-Hb, by reductive alkylation chemistry. CD (circular dichroism) spectral measurements indicated that the overall secondary structure of Hb is not adversely influenced upon PEGylation. (Propyl-PEG5k)6-Hb exhibited an increased O2 affinity with decreased co-operativity and decreased modulation by allosteric effectors comparable with that of (SP-PEG5k)6-Hb, although its Cys-93(β) is not derivatized as in the latter. On a molecular mass basis, PEG linked to Hb by reductive alkylation increased its COP (colloidal osmotic pressure) more efficiently than when linked by thiolation-mediated maleimide-chemistry. These results demonstrate that the functional properties of PEG–Hb conjugates may be a direct consequence of surface decoration of Hb with PEG, but are independent of the site (pattern) and/or the chemistry of PEGylation. However the solution properties of PEGylated Hb are influenced by the site (pattern) and/or the chemistry of PEGylation and the presence or absence of an ‘extension arm’ between the conjugating site of Hb and the PEG chain.

Fe3O4 nanoparticles functionalized with poly(ethylene glycol) for the selective separation and enrichment of Au(iii)

2020 ◽  
Vol 44 (4) ◽  
pp. 1313-1319
Author(s):  
Xu Yang ◽  
Kunhao Yang ◽  
Li Wu ◽  
Jingkui Yang ◽  
Yujian He
Keyword(s):  
Aqueous Solution ◽  
Magnetic Nanoparticles ◽  
Ethylene Glycol ◽  
Fe3o4 Nanoparticles ◽  
Selective Separation ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Mechanism of Fe3O4@CPTES@PEG magnetic nanoparticles for selectively adsorbing Au(iii) from aqueous solution at pH = 1.0.

Thermogelation Properties of ABA Triblock Copolymers of Poly(Ethylene Glycol) (B) and Copolyacrylates of Oligo(Ethylene Glycol)s (A) in Aqueous Solution

2013 ◽  
Vol 11 (2) ◽  
pp. 149-156 ◽  
Author(s):  
Ioana Negru ◽  
Mircea Teodorescu ◽  
Paul O. Stănescu ◽  
Constantin Drăghici ◽  
Anamaria Lungu ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Ethylene Glycol ◽  
Triblock Copolymers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Multiple Lyotropic Polymorphism of a Poly(ethylene glycol)-Peptide Conjugate in Aqueous Solution

2008 ◽  
Vol 20 (23) ◽  
pp. 4394-4397 ◽  
Author(s):  
Ian W. Hamley ◽  
Marta J. Krysmann ◽  
Valeria Castelletto ◽  
Laurence Noirez
Keyword(s):  
Aqueous Solution ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Multiple Lyotropic Polymorphism of a Poly(ethylene glycol)-Peptide Conjugate in Aqueous Solution

2008 ◽  
Vol 20 (23) ◽  
pp. NA-NA
Author(s):  
Ian W. Hamley ◽  
Marta J. Krysmann ◽  
Valeria Castelletto ◽  
Laurence Noirez
Keyword(s):  
Aqueous Solution ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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