Modifying the Hydrophilic–Hydrophobic Interface of PEG-b-PCL To Increase Micelle Stability: Preparation of PEG-b-PBO-b-PCL Triblock Copolymers, Micelle Formation, and Hydrolysis Kinetics

2012 ◽  
Vol 45 (2) ◽  
pp. 660-665 ◽  
Author(s):  
Xiaobo Zhu ◽  
Michael Fryd ◽  
Benjamin D. Tran ◽  
Marc A. Ilies ◽  
Bradford B. Wayland
Keyword(s):  
Triblock Copolymers ◽  
Micelle Formation ◽  
Hydrolysis Kinetics ◽  
Hydrophobic Interface

Supramolecular ABA Triblock Copolymers via a Polycondensation Approach:  Synthesis, Characterization, and Micelle Formation

2006 ◽  
Vol 39 (4) ◽  
pp. 1569-1576 ◽  
Author(s):  
Michael A. R. Meier ◽  
Daan Wouters ◽  
Christina Ott ◽  
Pierre Guillet ◽  
Charles-André Fustin ◽  
...  
Keyword(s):  
Triblock Copolymers ◽  
Micelle Formation

Polyethylene Oxide-Polystyrene Oxide Triblock Copolymers as Biological-Responsive Nanocarriers.

2012 ◽  
Vol 1468 ◽  
Author(s):  
Adriana Cambón ◽  
Ana Rey-Rico ◽  
Silvia Barbosa ◽  
Jose Brea ◽  
M. I. Loza ◽  
...  
Keyword(s):  
Cell Line ◽  
Polyethylene Oxide ◽  
Triblock Copolymers ◽  
Styrene Oxide ◽  
Temporal Stability ◽  
Tumor Cell Line ◽  
Micelle Formation ◽  
Multidrug Resistant ◽  
Drug Release Profile

ABSTRACTThe present work presents the synthesis, characterization and evaluation of the biocompatibility and ability to dissolve and chemically protect the anticancer drug doxorubicin (DOXO) of two polyethylene oxide-polystyrene oxide triblock copolymers, EO33SO13EO33 and EO38SO10EO38, where EO and SO denote the ethylene oxide and styrene oxide blocks, respectively. Block copolymer length and SO/EO ratio were selected with the objective of ensuring an optimal compromise between chain solubility, micelle formation ability and core size for enhanced drug solubilization. The temporal stability of the drug-loaded micelles and drug release profile were also analyzed as well as their efficacy as an antitumoral polymeric formulation in vitro by using a multidrug resistant ovarian tumor cell line (NCI-ADR-RES), with the special aim of analyzing the possible capability of both copolymers as potential P-glycoprotein efflux (P-gp) pump inhibitors to enhance DOXO accumulation in this cell line.

Micelle formation of BAB triblock copolymers in solvents that preferentially dissolve the A block

1991 ◽  
Vol 24 (8) ◽  
pp. 1975-1986 ◽  
Author(s):  
N. P. Balsara ◽  
M. Tirrell ◽  
T. P. Lodge
Keyword(s):  
Triblock Copolymers ◽  
Micelle Formation

Supramolecular flower micelle formation of polyrotaxane-containing triblock copolymers prepared from macro-chain transfer agents bearing molecular hooks

2014 ◽  
Vol 5 (15) ◽  
pp. 4511-4520 ◽  
Author(s):  
Atsushi Tamura ◽  
Hajime Tanaka ◽  
Nobuhiko Yui
Keyword(s):  
Aqueous Solution ◽  
Chain Transfer ◽  
Triblock Copolymers ◽  
Micelle Formation ◽  
Polymeric Micelle ◽  
Transfer Agents

A precise synthesis of polyrotaxanes (PRX)-containing triblock copolymers was achieved using PRX macro-chain transfer agents with terminal hooks. Also, polymeric micelle formation of them in aqueous solution was investigated.

Self-Assembly of Hydrogels From Elastin-Mimetic Block Copolymers

2002 ◽  
Vol 724 ◽  
Author(s):  
Elizabeth R. Wright ◽  
R. Andrew McMillan ◽  
Alan Cooper ◽  
Robert P. Apkarian ◽  
Vincent P. Conticello
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Variable Temperature ◽  
Inverse Temperature ◽  
Temperature Transition ◽  
Scanning Calorimetry ◽  
Design Synthesis ◽  
Inverse Temperature Transition ◽  
Functional Biomaterials

AbstractTriblock copolymers have traditionally been synthesized with conventional organic components. However, triblock copolymers could be synthesized by the incorporation of two incompatible protein-based polymers. The polypeptides would differ in their hydrophobicity and confer unique physiochemical properties to the resultant materials. One protein-based polymer, based on a sequence of native elastin, that has been utilized in the synthesis of biomaterials is poly (Valine-Proline-Glycine-ValineGlycine) or poly(VPGVG) [1]. This polypeptide has been shown to have an inverse temperature transition that can be adjusted by non-conservative amino acid substitutions in the fourth position [2]. By combining polypeptide blocks with different inverse temperature transition values due to hydrophobicity differences, we expect to produce amphiphilic polypeptides capable of self-assembly into hydrogels. Our research examines the design, synthesis and characterization of elastin-mimetic block copolymers as functional biomaterials. The methods that are used for the characterization include variable temperature 1D and 2D High-Resolution-NMR, cryo-High Resolutions Scanning Electron Microscopy and Differential Scanning Calorimetry.

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