Triblock Copolymers with Grafted Fluorine-Free, Amphiphilic, Non-Ionic Side Chains for Antifouling and Fouling-Release Applications

2011 ◽  
Vol 44 (12) ◽  
pp. 4783-4792 ◽  
Author(s):  
Youngjin Cho ◽  
Harihara S. Sundaram ◽  
Craig J. Weinman ◽  
Marvin Y. Paik ◽  
Michael D. Dimitriou ◽  
...  
Keyword(s):  
Triblock Copolymers ◽  
Side Chains ◽  
Fouling Release

Amphiphilic Surface Active Triblock Copolymers with Mixed Hydrophobic and Hydrophilic Side Chains for Tuned Marine Fouling-Release Properties

Langmuir ◽  
2010 ◽  
Vol 26 (12) ◽  
pp. 9772-9781 ◽  
Author(s):  
Daewon Park ◽  
Craig J. Weinman ◽  
John A. Finlay ◽  
Benjamin R. Fletcher ◽  
Marvin Y. Paik ◽  
...  
Keyword(s):  
Triblock Copolymers ◽  
Side Chains ◽  
Marine Fouling ◽  
Fouling Release ◽  
Surface Active

More Is Less: Curcumin and Paclitaxel Formulations Using Poly(2-Oxazoline) and Poly(2-Oxazine) Based Amphiphiles Bearing Linear and Branched C9 Side Chains

2018 ◽  
Author(s):  
Michael M. Lübtow ◽  
Larissa Keßler ◽  
Thomas Lorson ◽  
Niklas Gangloff ◽  
Marius Kirsch ◽  
...  
Keyword(s):  
Triblock Copolymers ◽  
Side Chain ◽  
Side Chains ◽  
General Strategy ◽  
Loading Capacity ◽  
Hydrophobic Core ◽  
Polymer Micelles ◽  
Drug Solubilization ◽  
Solubilization Capacity ◽  
Insoluble Compounds

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 11.0px Helvetica} <p>A known limitation of polymer micelles for the formulation of hydrophobic drugs is their low loading capacity, which rarely exceeds 20 wt.%. One general strategy to overcome this limitation is to increase the amphiphilic contrast, i.e. to make the hydrophobic core of the micelles more hydrophobic. However, we reported earlier that for poly(2-oxazoline) based amphiphilic triblock copolymers, a minimal amphiphilic contrast is beneficial, which was tentatively attributed to possible side chain crystallization. Here, we revisit this subject in more detail using more hydrophobic side chains that are either linear (nonyl) or branched (3-ethylheptyl), the latter of which should not crystallize. Moreover, we investigate two different backbones within the hydrophobic block, in particular poly(2-oxazoline) and poly(2-oxazine), for the solubilization and co-solubilization of the two highly water insoluble compounds curcumin and paclitaxel. Even though high loading capacities could be achieved for curcumin within poly(2-oxazine) based triblock copolymers, the solubilization capacity of all investigated polymers with longer side chains was significantly lower compared to poly(2-oxazoline)s and poly(2-oxazine)s with shorter side chains. Although the even lower loading capacity for paclitaxel could be somehow attenuated by co-formulating curcumin, this study corroborates that in the case of poly(2-oxazoline) and poly(2-oxazine) based polymer micelles, an increased amphiphilic contrast leads to less drug solubilization.</p>

scholarly journals Fluorine-free mixed amphiphilic polymers based on PDMS and PEG side chains for fouling release applications

Biofouling ◽  
2011 ◽  
Vol 27 (6) ◽  
pp. 589-602 ◽  
Author(s):  
Harihara S. Sundaram ◽  
Youngjin Cho ◽  
Michael D. Dimitriou ◽  
Craig J. Weinman ◽  
John A. Finlay ◽  
...  
Keyword(s):  
Amphiphilic Polymers ◽  
Side Chains ◽  
Fouling Release

ABC Triblock Surface Active Block Copolymer with Grafted Ethoxylated Fluoroalkyl Amphiphilic Side Chains for Marine Antifouling/Fouling-Release Applications

Langmuir ◽  
2009 ◽  
Vol 25 (20) ◽  
pp. 12266-12274 ◽  
Author(s):  
Craig J. Weinman ◽  
John A. Finlay ◽  
Daewon Park ◽  
Marvin Y. Paik ◽  
Sitaraman Krishnan ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Side Chains ◽  
Fouling Release ◽  
Surface Active ◽  
Marine Antifouling ◽  
Active Block

scholarly journals Amphiphilic triblock copolymers with PEGylated hydrocarbon structures as environmentally friendly marine antifouling and fouling-release coatings

Biofouling ◽  
2014 ◽  
Vol 30 (5) ◽  
pp. 589-604 ◽  
Author(s):  
Zhaoli Zhou ◽  
David R. Calabrese ◽  
Warren Taylor ◽  
John A. Finlay ◽  
Maureen E. Callow ◽  
...  
Keyword(s):  
Triblock Copolymers ◽  
Environmentally Friendly ◽  
Fouling Release ◽  
Marine Antifouling

More Is Less: Curcumin and Paclitaxel Formulations Using Poly(2-Oxazoline) and Poly(2-Oxazine) Based Amphiphiles Bearing Linear and Branched C9 Side Chains

2018 ◽  
Author(s):  
Michael M. Lübtow ◽  
Larissa Keßler ◽  
Thomas Lorson ◽  
Niklas Gangloff ◽  
Marius Kirsch ◽  
...  
Keyword(s):  
Triblock Copolymers ◽  
Side Chain ◽  
Side Chains ◽  
General Strategy ◽  
Loading Capacity ◽  
Hydrophobic Core ◽  
Polymer Micelles ◽  
Drug Solubilization ◽  
Solubilization Capacity ◽  
Insoluble Compounds

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 11.0px Helvetica} <p>A known limitation of polymer micelles for the formulation of hydrophobic drugs is their low loading capacity, which rarely exceeds 20 wt.%. One general strategy to overcome this limitation is to increase the amphiphilic contrast, i.e. to make the hydrophobic core of the micelles more hydrophobic. However, we reported earlier that for poly(2-oxazoline) based amphiphilic triblock copolymers, a minimal amphiphilic contrast is beneficial, which was tentatively attributed to possible side chain crystallization. Here, we revisit this subject in more detail using more hydrophobic side chains that are either linear (nonyl) or branched (3-ethylheptyl), the latter of which should not crystallize. Moreover, we investigate two different backbones within the hydrophobic block, in particular poly(2-oxazoline) and poly(2-oxazine), for the solubilization and co-solubilization of the two highly water insoluble compounds curcumin and paclitaxel. Even though high loading capacities could be achieved for curcumin within poly(2-oxazine) based triblock copolymers, the solubilization capacity of all investigated polymers with longer side chains was significantly lower compared to poly(2-oxazoline)s and poly(2-oxazine)s with shorter side chains. Although the even lower loading capacity for paclitaxel could be somehow attenuated by co-formulating curcumin, this study corroborates that in the case of poly(2-oxazoline) and poly(2-oxazine) based polymer micelles, an increased amphiphilic contrast leads to less drug solubilization.</p>

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