Phase Behavior of a Weakly Interacting Block Copolymer by Temperature-Dependent FTIR Spectroscopy

2006 ◽  
Vol 39 (1) ◽  
pp. 408-412 ◽  
Author(s):  
Hye Jeong Kim ◽  
Seung Bin Kim ◽  
Jin Kon Kim ◽  
Young Mee Jung ◽  
Du Yeol Ryu ◽  
...  
2008 ◽  
Vol 64 (a1) ◽  
pp. C146-C146
Author(s):  
P. Thiyagarajan ◽  
V. Pol ◽  
D. Bohnsack ◽  
C.-T. Lo ◽  
B. Lee ◽  
...  

1999 ◽  
Vol 32 (3) ◽  
pp. 637-645 ◽  
Author(s):  
Mårten Svensson ◽  
Paschalis Alexandridis ◽  
Per Linse

2008 ◽  
pp. 391-417 ◽  
Author(s):  
Carlos Rodrguez ◽  
Arturo Lpez-Quintela ◽  
Md. Hemayet Uddin ◽  
Kenji Aramaki ◽  
Hironobu Kunieda

2020 ◽  
Vol 12 (51) ◽  
pp. 57421-57430
Author(s):  
Michael D. Galluzzo ◽  
Whitney S. Loo ◽  
Eric Schaible ◽  
Chenhui Zhu ◽  
Nitash P. Balsara

Science ◽  
2020 ◽  
Vol 367 (6478) ◽  
pp. 694-699 ◽  
Author(s):  
Erik W. Martin ◽  
Alex S. Holehouse ◽  
Ivan Peran ◽  
Mina Farag ◽  
J. Jeremias Incicco ◽  
...  

Prion-like domains (PLDs) can drive liquid-liquid phase separation (LLPS) in cells. Using an integrative biophysical approach that includes nuclear magnetic resonance spectroscopy, small-angle x-ray scattering, and multiscale simulations, we have uncovered sequence features that determine the overall phase behavior of PLDs. We show that the numbers (valence) of aromatic residues in PLDs determine the extent of temperature-dependent compaction of individual molecules in dilute solutions. The valence of aromatic residues also determines full binodals that quantify concentrations of PLDs within coexisting dilute and dense phases as a function of temperature. We also show that uniform patterning of aromatic residues is a sequence feature that promotes LLPS while inhibiting aggregation. Our findings lead to the development of a numerical stickers-and-spacers model that enables predictions of full binodals of PLDs from their sequences.


1998 ◽  
Vol 108 (7) ◽  
pp. 2989-3000 ◽  
Author(s):  
Wayne W. Maurer ◽  
Frank S. Bates ◽  
Timothy P. Lodge ◽  
Kristoffer Almdal ◽  
Kell Mortensen ◽  
...  

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