scholarly journals Role of Architecture on the Conformation, Rheology, and Orientation Behavior of Linear, Star, and Hyperbranched Polymer Melts. 1. Synthesis and Molecular Characterization

2003 ◽  
Vol 36 (2) ◽  
pp. 399-406 ◽  
Author(s):  
Semen B. Kharchenko ◽  
Rangaramanujam M. Kannan ◽  
Jeff J. Cernohous ◽  
Shivshankar Venkataramani
Shock ◽  
1997 ◽  
Vol 7 (3) ◽  
pp. 157-163 ◽  
Author(s):  
Edward Kelly ◽  
Nishit S. Shah ◽  
Nathan N. Morgan ◽  
Simon C. Watkins ◽  
Andrew B. Peitzman ◽  
...  

Blood ◽  
2015 ◽  
Vol 125 (22) ◽  
pp. 3388-3392 ◽  
Author(s):  
Olli Silvennoinen ◽  
Stevan R. Hubbard

Abstract The critical role of Janus kinase-2 (JAK2) in regulation of myelopoiesis was established 2 decades ago, but identification of mutations in the pseudokinase domain of JAK2 in myeloproliferative neoplasms (MPNs) and in other hematologic malignancies highlighted the role of JAK2 in human disease. These findings have revolutionized the diagnostics of MPNs and led to development of novel JAK2 therapeutics. However, the molecular mechanisms by which mutations in the pseudokinase domain lead to hyperactivation of JAK2 and clinical disease have been unclear. Here, we describe recent advances in the molecular characterization of the JAK2 pseudokinase domain and how pathogenic mutations lead to constitutive activation of JAK2.


2015 ◽  
Vol 70 (9) ◽  
pp. 2488-2498 ◽  
Author(s):  
Sushmita D. Lahiri ◽  
Robert E. McLaughlin ◽  
James D. Whiteaker ◽  
Jane E. Ambler ◽  
Richard A. Alm

2007 ◽  
Vol 40 (17) ◽  
pp. 6325-6332 ◽  
Author(s):  
Regis Schach ◽  
Yvette Tran ◽  
Alain Menelle ◽  
Costantino Creton

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