scholarly journals Molecular characterization of MRSA isolates bracketing the current EUCAST ceftaroline-susceptible breakpoint forStaphylococcus aureus: the role of PBP2a in the activity of ceftaroline

2015 ◽  
Vol 70 (9) ◽  
pp. 2488-2498 ◽  
Author(s):  
Sushmita D. Lahiri ◽  
Robert E. McLaughlin ◽  
James D. Whiteaker ◽  
Jane E. Ambler ◽  
Richard A. Alm
Keyword(s):  
Molecular Characterization

PHYSIOLOGIC AND MOLECULAR CHARACTERIZATION OF THE ROLE OF NITRIC OXIDE IN HEMORRHAGIC SHOCK

Shock ◽  
1997 ◽  
Vol 7 (3) ◽  
pp. 157-163 ◽  
Author(s):  
Edward Kelly ◽  
Nishit S. Shah ◽  
Nathan N. Morgan ◽  
Simon C. Watkins ◽  
Andrew B. Peitzman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Hemorrhagic Shock ◽  
Molecular Characterization

scholarly journals Molecular insights into regulation of JAK2 in myeloproliferative neoplasms

Blood ◽  
2015 ◽  
Vol 125 (22) ◽  
pp. 3388-3392 ◽  
Author(s):  
Olli Silvennoinen ◽  
Stevan R. Hubbard
Keyword(s):  
Molecular Characterization ◽  
Human Disease ◽  
Molecular Mechanisms ◽  
Myeloproliferative Neoplasms ◽  
Critical Role ◽  
Hematologic Malignancies ◽  
Janus Kinase ◽  
Constitutive Activation

Abstract The critical role of Janus kinase-2 (JAK2) in regulation of myelopoiesis was established 2 decades ago, but identification of mutations in the pseudokinase domain of JAK2 in myeloproliferative neoplasms (MPNs) and in other hematologic malignancies highlighted the role of JAK2 in human disease. These findings have revolutionized the diagnostics of MPNs and led to development of novel JAK2 therapeutics. However, the molecular mechanisms by which mutations in the pseudokinase domain lead to hyperactivation of JAK2 and clinical disease have been unclear. Here, we describe recent advances in the molecular characterization of the JAK2 pseudokinase domain and how pathogenic mutations lead to constitutive activation of JAK2.

scholarly journals Molecular characterization of Kv2.1 channels in sheep vasculature: Role of Kv channels in regulating vascular tone

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
K Dinesh ◽  
S Hirenallur ◽  
Avinash G Telang ◽  
Santhosh K Mishra
Keyword(s):  
Molecular Characterization ◽  
Vascular Tone ◽  
Kv Channels

scholarly journals Molecular characterization of encephalomyocarditis virus strains isolated from an African elephant and rats in a French zoo

2020 ◽  
pp. 104063872097838
Author(s):  
Aurore Romey ◽  
Benjamin Lamglait ◽  
Yannick Blanchard ◽  
Fabrice Touzain ◽  
Helene Quenault ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Genome Sequencing ◽  
Rattus Rattus ◽  
African Elephant ◽  
Encephalomyocarditis Virus ◽  
Nucleotide Sequence Level ◽  
Genome Analyses ◽  
3D Sequences

In November 2013, a fatal encephalomyocarditis virus (EMCV) case in a captive African elephant ( Loxodonta africana) occurred at the Réserve Africaine de Sigean, a zoo in the south of France. Here we report the molecular characterization of the EMCV strains isolated from samples collected from the dead elephant and from 3 rats ( Rattus rattus) captured in the zoo at the same time. The EMCV infection was confirmed by reverse-transcription real-time PCR (RT-rtPCR) and genome sequencing. Complete genome sequencing and sequence alignment indicated that the elephant’s EMCV strain was 98.1–99.9% identical to the rat EMCV isolates at the nucleotide sequence level. Phylogenetic analysis of the ORF, P1, VP1, and 3D sequences revealed that the elephant and rat strains clustered into lineage A of the EMCV 1 group. To our knowledge, molecular characterization of EMCV in France and Europe has not been reported previously in a captive elephant. The full genome analyses of EMCV isolated from an elephant and rats in the same outbreak emphasizes the role of rodents in EMCV introduction and circulation in zoos.

Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver

Hepatology ◽  
2007 ◽  
Vol 46 (1) ◽  
pp. 147-157 ◽  
Author(s):  
Jiansheng Huang ◽  
Jahangir Iqbal ◽  
Pradip K. Saha ◽  
Jun Liu ◽  
Lawrence Chan ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Molecular Characterization ◽  
Orphan Receptor ◽  
Small Heterodimer Partner
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