Synthesis of Sulfated Alkyl Malto-oligosaccharides with Potent Inhibitory Effects on AIDS Virus Infection

1995 ◽  
Vol 28 (20) ◽  
pp. 6697-6700 ◽  
Author(s):  
Kaname Katsuraya ◽  
Takashi Shibuya ◽  
Kazuhiko Inazawa ◽  
Hideki Nakashima ◽  
Naoki Yamamoto ◽  
...  
Keyword(s):  
Virus Infection ◽  
Inhibitory Effects ◽  
Aids Virus

scholarly journals Synthesis of Azidothymidine-Bound Sulfated Alkyl Oligosaccharides and Their Inhibitory Effects on AIDS Virus Infection in vitro

1998 ◽  
Vol 30 (3) ◽  
pp. 243-248 ◽  
Author(s):  
Ying Gao ◽  
Kaname Katsuraya ◽  
Yutaro Kaneko ◽  
Toru Mimura ◽  
Hideki Nakashima ◽  
...  
Keyword(s):  
Virus Infection ◽  
Inhibitory Effects ◽  
Aids Virus

ChemInform Abstract: Synthesis of Sulfated Alkyl Malto- and Laminara-oligosaccharides with Potent Inhibitory Effects on AIDS Virus Infection.

ChemInform ◽  
2010 ◽  
Vol 25 (44) ◽  
pp. no-no
Author(s):  
K. KATSURAYA ◽  
N. IKUSHIMA ◽  
N. TAKAHASHI ◽  
T. SHOJI ◽  
H. NAKASHIMA ◽  
...  
Keyword(s):  
Virus Infection ◽  
Inhibitory Effects ◽  
Aids Virus

Synthesis of sulfated alkyl malto- and laminara-oligosaccharides with potent inhibitory effects on AIDS virus infection

1994 ◽  
Vol 260 (1) ◽  
pp. 51-61 ◽  
Author(s):  
Kaname Katsuraya ◽  
Naoya Ikushima ◽  
Nahoko Takahashi ◽  
Tadao Shoji ◽  
Hideki Nakashima ◽  
...  
Keyword(s):  
Virus Infection ◽  
Inhibitory Effects ◽  
Aids Virus

he novel therapeutic target and inhibitory effects of PF-429242 against Zika virus infection

2021 ◽  
pp. 105121
Author(s):  
Sandra Kendra Raini ◽  
Yuki Takamatsu ◽  
Shyam Prakash Dumre ◽  
Shuzo Urata ◽  
Shusaku Mizukami ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Therapeutic Target ◽  
Inhibitory Effects ◽  
Zika Virus Infection ◽  
Novel Therapeutic

An animal model for understanding the immunogenetics of AIDS virus infection

2000 ◽  
pp. 320-326
Author(s):  
Carol M. Kiekhaefer ◽  
David T. Evans ◽  
David H. O’Connor ◽  
David I. Watkins
Keyword(s):  
Animal Model ◽  
Virus Infection ◽  
Aids Virus

Synthesis and structural analysis of curdlan sulfate with a potent inhibitory effect in vitro of AIDS virus infection

1990 ◽  
Vol 23 (16) ◽  
pp. 3717-3722 ◽  
Author(s):  
Takashi Yoshida ◽  
Kenichi Hatanaka ◽  
Toshiyuki Uryu ◽  
Yutaro Kaneko ◽  
Eiichiro Suzuki ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Virus Infection ◽  
Inhibitory Effect ◽  
Aids Virus ◽  
Potent Inhibitory Effect

scholarly journals Comparison of the inhibitory effects of interferon alfacon-1 and ribavirin on yellow fever virus infection in a hamster model

2007 ◽  
Vol 73 (2) ◽  
pp. 140-146 ◽  
Author(s):  
Justin G. Julander ◽  
John D. Morrey ◽  
Lawrence M. Blatt ◽  
Kristiina Shafer ◽  
Robert W. Sidwell
Keyword(s):  
Virus Infection ◽  
Yellow Fever ◽  
Yellow Fever Virus ◽  
Fever Virus ◽  
Inhibitory Effects ◽  
Hamster Model

Inhibitory effects of carbocisteine on type A seasonal influenza virus infection in human airway epithelial cells

2010 ◽  
Vol 299 (2) ◽  
pp. L160-L168 ◽  
Author(s):  
Mutsuo Yamaya ◽  
Hidekazu Nishimura ◽  
Kyoko Shinya ◽  
Yukimasa Hatachi ◽  
Takahiko Sasaki ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Epithelial Cells ◽  
Virus Infection ◽  
Seasonal Influenza ◽  
Influenza Virus Infection ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Human Influenza ◽  
Inhibitory Effects ◽  
Human Influenza Virus

Type A human seasonal influenza (FluA) virus infection causes exacerbations of bronchial asthma and chronic obstructive pulmonary disease (COPD). l-carbocisteine, a mucolytic agent, reduces the frequency of common colds and exacerbations in COPD. However, the inhibitory effects of l-carbocisteine on FluA virus infection are uncertain. We studied the effects of l-carbocisteine on FluA virus infection in airway epithelial cells. Human tracheal epithelial cells were pretreated with l-carbocisteine and infected with FluA virus (H3N2). Viral titers in supernatant fluids, RNA of FluA virus in the cells, and concentrations of proinflammatory cytokines in supernatant fluids, including IL-6, increased with time after infection. l-carbocisteine reduced viral titers in supernatant fluids, RNA of FluA virus in the cells, the susceptibility to FluA virus infection, and concentrations of cytokines induced by virus infection. The epithelial cells expressed sialic acid with an α2,6-linkage (SAα2,6Gal), a receptor for human influenza virus on the cells, and l-carbocisteine reduced the expression of SAα2,6Gal. l-carbocisteine reduced the number of acidic endosomes from which FluA viral RNA enters into the cytoplasm and reduced the fluorescence intensity from acidic endosomes. Furthermore, l-carbocisteine reduced NF-κB proteins including p50 and p65 in the nuclear extracts of the cells. These findings suggest that l-carbocisteine may inhibit FluA virus infection, partly through the reduced expression of the receptor for human influenza virus in the human airway epithelial cells via the inhibition of NF-κB and through increasing pH in endosomes. l-carbocisteine may reduce airway inflammation in influenza virus infection.

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