Prediction of Critical Micelle Concentrations of Nonideal Ternary Surfactant Mixtures

Langmuir ◽  
1998 ◽  
Vol 14 (15) ◽  
pp. 4105-4114 ◽  
Author(s):  
Anat Shiloach ◽  
Daniel Blankschtein
Keyword(s):  
Surfactant Mixtures ◽  
Critical Micelle Concentrations

Solubilization of pada in Hydrocarbon Fluorocarbon Surfactant Mixtures

1992 ◽  
Vol 45 (4) ◽  
pp. 769 ◽  
Author(s):  
TJ Connolly ◽  
VC Reinsborough ◽  
XY Xiang
Keyword(s):  
Mixed Micelle ◽  
Mixed Micelles ◽  
Surfactant Mixtures ◽  
Critical Micelle Concentrations ◽  
Fluorocarbon Surfactant ◽  
Surfactant Systems ◽  
Sodium Decyl Sulfate ◽  
Sodium Perfluorooctanoate

Solubilities of pyridine-2-azo-p-dimethylaniline ( pada ) were determined at 25�C in four mixed fluorocarbon/hydrocarbon short-chained surfactant systems: ( i ) sodium decyl sulfate/sodium perfluoroheptanoate; (ii) sodium octanesulfonate /sodium perfluorooctanoate ; (iii) sodium octanesulfonate /sodium perfluoroheptanoate ; (iv) sodium nonanesulfonate /sodium perfluoroheptanoate. Systems ( i ), (iii) and (iv) showed micellar miscibility (one mixed micelle) and synergistic solubilization effects. System (ii) had two critical micelle concentrations pointing to two micellar forms in solution, and no synergism could be detected. From these four examples, it is deduced that single mixed micelles are formed when the critical micelle concentrations of the pure surfactants are within a factor of 3 of each other.

Prediction of critical micelle concentrations of nonideal binary surfactant mixtures

Langmuir ◽  
1992 ◽  
Vol 8 (11) ◽  
pp. 2690-2697 ◽  
Author(s):  
Claudia Sarmoria ◽  
Sudhakar Puvvada ◽  
Daniel Blankschtein
Keyword(s):  
Surfactant Mixtures ◽  
Critical Micelle Concentrations

Critical micelle concentrations and interaction parameters of aqueous binary surfactant:ionic surfactant mixtures

2005 ◽  
Vol 288 (1) ◽  
pp. 238-246 ◽  
Author(s):  
Hideo Akisada ◽  
Junko Kuwahara ◽  
Kouji Noyori ◽  
Ryobun Kuba ◽  
Takashi Shimooka ◽  
...  
Keyword(s):  
Interaction Parameters ◽  
Surfactant Mixtures ◽  
Critical Micelle Concentrations

scholarly journals Critical Micelle Concentrations in Surfactant Mixtures and Blends by Simulation

2021 ◽  
Author(s):  
Annalaura Del Regno ◽  
Patrick B. Warren ◽  
David J. Bray ◽  
Richard L. Anderson
Keyword(s):  
Surfactant Mixtures ◽  
Critical Micelle Concentrations

Phase behavior of cationic and anionic surfactants at low concentrations

1992 ◽  
Vol 50 (1) ◽  
pp. 694-695
Author(s):  
E. Naranjo
Keyword(s):  
Phase Behavior ◽  
Structural Characterization ◽  
Dynamic Systems ◽  
Anionic Surfactants ◽  
Intermolecular Forces ◽  
Stable Form ◽  
Surfactant Mixtures ◽  
Low Concentrations ◽  
Cationic And Anionic Surfactants ◽  
General Method

Equilibrium vesicles, those which are the stable form of aggregation and form spontaneously on mixing surfactant with water, have never been demonstrated in single component bilayers and only rarely in lipid or surfactant mixtures. Designing a simple and general method for producing spontaneous and stable vesicles depends on a better understanding of the thermodynamics of aggregation, the interplay of intermolecular forces in surfactants, and an efficient way of doing structural characterization in dynamic systems.

Solubilization of Itraconazole by Surfactants and Phospholipid-Surfactant Mixtures: Interplay of Amphiphile Structure, pH and Electrostatic Interactions

2020 ◽  
Author(s):  
Zahari Vinarov ◽  
Gabriela Gancheva ◽  
Nikola Burdzhiev ◽  
Slavka S. Tcholakova
Keyword(s):  
Nmr Spectroscopy ◽  
Electrostatic Interactions ◽  
Triazole Ring ◽  
Water Soluble ◽  
Single Chain ◽  
Surfactant Mixtures ◽  
Solubilization Capacity ◽  
Water Soluble Drugs ◽  
Hydrophobic Chain ◽  
Brick Dust

Although surfactants are frequently used in enabling formulations of poorly water-soluble drugs, the link between their structure and drug solubilization capacity is still unclear. We studied the solubilization of the “brick-dust” molecule itraconazole by 16 surfactants and 3 phospholipid:surfactant mixtures. NMR spectroscopy was used to study in more details the drug-surfactant interactions. Very high solubility of itraconazole (up to 3.6 g/L) was measured in anionic surfactant micelles at pH = 3, due to electrostatic attraction between the oppositely charged (at this pH) drug and surfactant molecules. <sup>1</sup>H NMR spectroscopy showed that itraconazole is ionized at two sites (2+ charge) at these conditions: in the phenoxy-linked piperazine nitrogen and in the dioxolane-linked triazole ring. The increase of amphiphile hydrophobic chain length had a markedly different effect, depending on the amphiphile type: the solubilization capacity of single-chain surfactants increased, whereas a decrease was observed for double-chained surfactants (phosphatidylglycerols). The excellent correlation between the chain melting temperatures of phosphatidylglycerols and itraconazole solubilization illustrated the importance of hydrophobic chain mobility. This study provides rules for selection of itraconazole solubilizers among classical single-chain surfactants and phospholipids. The basic physics underpinning the described effects suggests that these rules should be transferrable to other “brick-dust” molecules.

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