Diverse nanostructures and gel behaviours contained in a thermo- and dual-pH-sensitive ABC (PNIPAM–PAA–P4VP) terpolymer in an aqueous solution

RSC Advances ◽  
2016 ◽  
Vol 6 (91) ◽  
pp. 88306-88314 ◽  
Author(s):  
Ping Yong ◽  
Yuejiao Yang ◽  
Zhiyong Wang ◽  
Liming Yang ◽  
Jie Chen
Keyword(s):  
Aqueous Solution ◽  
Triblock Copolymer ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Ph Sensitive ◽  
Reversible Addition ◽  
Subsequent Hydrolysis ◽  
Abc Triblock Copolymer

PNIPAM-b-PAA-b-P4VP (NAV), a thermo- and dual-pH-sensitive ABC triblock copolymer, was synthesized via sequential reversible addition–fragmentation chain transfer (RAFT) polymerization and subsequent hydrolysis.

scholarly journals Switchable Reversible Addition–Fragmentation Chain Transfer (RAFT) Polymerization in Aqueous Solution,N,N-Dimethylacrylamide

2011 ◽  
Vol 44 (17) ◽  
pp. 6738-6745 ◽  
Author(s):  
Daniel J. Keddie ◽  
Carlos Guerrero-Sanchez ◽  
Graeme Moad ◽  
Ezio Rizzardo ◽  
San H. Thang
Keyword(s):  
Aqueous Solution ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Reversible Addition

Synthesis of Zwitterionic Chimeric Polymersomes for Efficient Protein Loading and Intracellular Delivery

2021 ◽  
Author(s):  
bingbing zhao ◽  
Yuting Yan ◽  
Junmei Zhang ◽  
Enping Chen ◽  
Ke Wang ◽  
...  
Keyword(s):  
Ring Opening ◽  
Triblock Copolymer ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Intracellular Delivery ◽  
Ring Opening Polymerization ◽  
H Nmr ◽  
Protein Loading ◽  
Reversible Addition

A novel zwitterionic triblock copolymer of poly(dimethylamino carbonate)-polycaprolactone-poly((2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium) [PAC(DMA)-PCL-PMDMSA] was designed and synthesized via sequential ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer (RAFT) polymerization successively. The 1H NMR and...

Enzyme catalysis-induced RAFT polymerization in water for the preparation of epoxy-functionalized triblock copolymer vesicles

2018 ◽  
Vol 9 (39) ◽  
pp. 4908-4916 ◽  
Author(s):  
Qin Xu ◽  
Yuxuan Zhang ◽  
Xueliang Li ◽  
Jun He ◽  
Jianbo Tan ◽  
...  
Keyword(s):  
Enzyme Catalysis ◽  
Triblock Copolymer ◽  
Room Temperature ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Reversible Addition

Enzyme catalysis-induced aqueous reversible addition–fragmentation chain transfer (RAFT) polymerization was conducted at room temperature for the preparation of epoxy-functionalized triblock copolymer vesicles.

Synthesis, self-assembly and self-healing properties of organic–inorganic ABA triblock copolymers with poly(POSS acrylate) endblocks

2019 ◽  
Vol 10 (19) ◽  
pp. 2424-2435 ◽  
Author(s):  
Bingjie Zhao ◽  
Sen Xu ◽  
Sixun Zheng
Keyword(s):  
Self Assembly ◽  
Triblock Copolymer ◽  
Chain Transfer ◽  
Triblock Copolymers ◽  
Raft Polymerization ◽  
Self Healing ◽  
Reversible Addition ◽  
Aba Triblock Copolymer

A novel organic–inorganic ABA triblock copolymer with a poly(acrylate amide) (PAA) midblock and poly(POSS acrylate) [P(POSS)] endblocks was synthesized via sequential reversible addition–fragmentation chain transfer (RAFT) polymerization.

scholarly journals Synthesis, aqueous solution behavior and self-assembly of a dual pH/thermo-responsive fluorinated diblock terpolymer

2021 ◽  
Author(s):  
Panagiotis G. Falireas ◽  
Vincent Ladmiral ◽  
Bruno Ameduri
Keyword(s):  
Aqueous Solution ◽  
Self Assembly ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Solution Behavior ◽  
Dual Responsive ◽  
Reversible Addition ◽  
Block Terpolymers

The synthesis of fluorinated dual-responsive block terpolymers via sequential reversible addition–fragmentation chain transfer (RAFT) polymerization is presented.

Preparation of Thermo-Sensitive Supramolecular Hydrogels Formed from MPEG-b-PNIPAM-b-MPEG Triblock Copolymer with α-Cyclodextrin

2014 ◽  
Vol 934 ◽  
pp. 75-79 ◽  
Author(s):  
Xiao Feng Ye ◽  
Mi Zhou ◽  
Jing Ying Hu ◽  
Xin Qian
Keyword(s):  
Triblock Copolymer ◽  
Chain Transfer ◽  
Triblock Copolymers ◽  
Raft Polymerization ◽  
Inclusion Complexation ◽  
Gel Permeation Chromatography ◽  
H Nmr ◽  
Reversible Addition ◽  
Response Interval ◽  
Gel Permeation

To develop a new drug delivery matrix with the suitable responsive interval, a well-defined triblock copolymer MPEG-b-PNIPAM-b-MPEG was synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. Then, the supramolecular hydrogels were fabricated via inclusion complexation with α-cyclodextrin (α-CD) and the triblock copolymers in aqueous solutions. The triblock copolymers were characterized by 1H NMR and gel permeation chromatography (GPC), and the supramolecular structures of hydrogels was confirmed by DSC. The resultant hydrogels was found to be thermo-sensitive, and the response interval could be modulated by controlling the content of PNIPAM.

scholarly journals Semi-Fluorinated Di and Triblock Copolymer Nano-Objects Prepared via RAFT Alcoholic Dispersion Polymerization (PISA)

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2502
Author(s):  
Gregoire Desnos ◽  
Adrien Rubio ◽  
Chaimaa Gomri ◽  
Mathias Gravelle ◽  
Vincent Ladmiral ◽  
...  
Keyword(s):  
Self Assembly ◽  
Triblock Copolymer ◽  
Dispersion Polymerization ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
The Self ◽  
The Core ◽  
Transmission Electron ◽  
Reversible Addition ◽  
Polymerization Conditions

A set of well-defined amphiphilic, semi-fluorinated di and triblock copolymers were synthesized via polymerization-induced self-assembly (PISA) under alcoholic dispersion polymerization conditions. This study investigates the influence of the length, nature and position of the solvophobic semi-fluorinated block. A poly(N,N-dimethylaminoethyl methacrylate) was used as the stabilizing block to prepare the di and tri block copolymer nano-objects via reversible addition-fragmentation chain transfer (RAFT) controlled dispersion polymerization at 70 °C in ethanol. Benzylmethacrylate (BzMA) and semi-fluorinated methacrylates and acrylates with 7 (heptafluorobutyl methacrylate (HFBMA)), 13 (heneicosafluorododecyl methacrylate (HCFDDMA)) and 21 (tridecafluorooctyl acrylate (TDFOA)) fluorine atoms were used as monomers for the core-forming blocks. The RAFT polymerization of these semi-fluorinated monomers was monitored by SEC and 1H NMR. The evolution of the self-assembled morphologies was investigated by transmission electron microscopy (TEM). The results demonstrate that the order of the blocks and the number of fluorine atoms influence the microphase segregation of the core-forming blocks and the final morphology of the nano-objects.

Self-Healing Hydrophobic POSS-functionalized Fluorinated Copolymer via RAFT Polymerization and dynamic Diels-Alder Reaction

2021 ◽  
Author(s):  
Siva Ponnupandian ◽  
Prantik Mondal ◽  
Thomas Becker ◽  
Richard Hoogenboom ◽  
Andrew B Lowe ◽  
...  
Keyword(s):  
Chain Transfer ◽  
Raft Polymerization ◽  
Alder Reaction ◽  
Diels Alder ◽  
Self Healing ◽  
Diels Alder Reaction ◽  
Reversible Addition

This investigation reports the preparation of a tailor-made copolymer of furfuryl methacrylate (FMA) and trifluoroethyl methacrylate (TFEMA) via reversible addition-fragmentation chain transfer (RAFT) polymerization. The furfuryl groups of the copolymer...

scholarly journals Nano-Assemblies from Amphiphilic PnBA-b-POEGA Copolymers as Drug Nanocarriers

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1164
Author(s):  
Angeliki Chroni ◽  
Thomas Mavromoustakos ◽  
Stergios Pispas
Keyword(s):  
Molecular Weight ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Polymeric Nanocarriers ◽  
Reversible Addition ◽  
2D Noesy ◽  
Drug Nanocarriers ◽  
Glycol Methyl Ether ◽  
Different Molecular Weight

The focus of this study is the development of highly stable losartan potassium (LSR) polymeric nanocarriers. Two novel amphiphilic poly(n-butyl acrylate)-block-poly(oligo(ethylene glycol) methyl ether acrylate) (PnBA-b-POEGA) copolymers with different molecular weight (Mw) of PnBA are synthesized via reversible addition fragmentation chain transfer (RAFT) polymerization, followed by the encapsulation of LSR into both PnBA-b-POEGA micelles. Based on dynamic light scattering (DLS), the PnBA30-b-POEGA70 and PnBA27-b-POEGA73 (where the subscripts denote wt.% composition of the components) copolymers formed micelles of 10 nm and 24 nm in water. The LSR-loaded PnBA-b-POEGA nanocarriers presented increased size and greater mass nanostructures compared to empty micelles, implying the successful loading of LSR into the inner hydrophobic domains. A thorough NMR (nuclear magnetic resonance) characterization of the LSR-loaded PnBA-b-POEGA nanocarriers was conducted. Strong intermolecular interactions between the biphenyl ring and the butyl chain of LSR with the methylene signals of PnBA were evidenced by 2D-NOESY experiments. The highest hydrophobicity of the PnBA27-b-POEGA73 micelles contributed to an efficient encapsulation of LSR into the micelles exhibiting a greater value of %EE compared to PnBA30-b-POEGA70 + 50% LSR nanocarriers. Ultrasound release profiles of LSR signified that a great amount of the encapsulated LSR is strongly attached to both PnBA30-b-POEGA70 and PnBA27-b-POEGA73 micelles.

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