Optically Active Supramolecular Complexes of Water-Soluble Achiral Polythiophenes and Folic Acid: Spectroscopic Studies and Sensing Applications

Langmuir ◽  
2008 ◽  
Vol 24 (22) ◽  
pp. 12829-12835 ◽  
Author(s):  
Zhiyi Yao ◽  
Chun Li ◽  
Gaoquan Shi
Keyword(s):  
Folic Acid ◽  
Spectroscopic Studies ◽  
Optically Active ◽  
Water Soluble ◽  
Supramolecular Complexes ◽  
Sensing Applications

A water-soluble cationic oligopyrene derivative: Spectroscopic studies and sensing applications

2009 ◽  
Vol 138 (2) ◽  
pp. 563-571 ◽  
Author(s):  
Youqiang Chen ◽  
Hua Bai ◽  
Qi Chen ◽  
Chun Li ◽  
Gaoquan Shi
Keyword(s):  
Spectroscopic Studies ◽  
Water Soluble ◽  
Sensing Applications

Spectroscopic studies of the interaction of cationic water-soluble iron(III) meso-tetrakis(4-N-methylpyridiniumyl)porphyrin (FeTMPyP) with ionic and nonionic micelles

2005 ◽  
Vol 09 (02) ◽  
pp. 94-108 ◽  
Author(s):  
Patrícia S. Santiago ◽  
Shirley C. M. Gandini ◽  
Marcel Tabak
Keyword(s):  
Optical Absorption ◽  
Binding Constants ◽  
Spectroscopic Studies ◽  
Resonance Light Scattering ◽  
Water Soluble ◽  
Absorption Data ◽  
Additional Species ◽  
Surfactant Aggregates ◽  
Order Of Magnitude ◽  
Triton X

Interactions of cationic FeTMPyP with ionic and nonionic micelles have been studied by optical absorption, resonance light scattering (RLS) and 1 H NMR spectroscopies. The equilibrium behavior of FeTMPyP as a function of pH is described by several species in aqueous solution. The presence of phosphate anions leads to the existence of additional species in the acid p H region, probably due to the coordination of phosphates to the iron. FeTMPyP solution as a function of pH in the presence of anionic SDS showed a simplified equilibrium in acidic pH region, favoring the transition to the dimeric species. Titration of FeTMPyP as a function of SDS surfactant concentration showed the presence of three different porphyrin species: free metalloporphyrin monomers (or dimers depending on pH), metalloporphyrin monomers (or dimers) bound to the micelles, and nonmicellar metalloporphyrin/surfactant aggregates. In the case of zwitterionic LPC and HPS, and nonionic TRITON X-100 the nonmicellar metalloporphyrin/surfactant aggregates were not observed. Binding constants were calculated from optical absorption data and have values of 2 × 103 M −1 for SDS being much smaller for HPS (58 M −1), LPC and TRITON X-100. Comparison with our previous data for anionic FeTPPS 4 shows that both the electrostatic factor and hydrophobic forces are relevant in the porphyrin-surfactant interaction: for FeTPPS 4 binding constants to cationic CTAC and zwitterionic HPS are of the same order of magnitude, 1-3 × 104 M −1; for FeTMPyP the delocalization of the positive charges from the periphery substituents into the macrocycle ring leads to reduction of both electrostatic attraction to the micelle as well as hydrophobic character of the porphyrin ring, leading to a 10-fold reduction of binding to the micelles of opposite charge to the porphyrin. NMR data indicated that FeTMPyP is bound to the micelles as an equilibrium of two forms of monomer at pH 2.0, and at pH 9.0 the bound aggregated form (possibly dimers) is observed predominantly with some amount of a monomeric form.

scholarly journals Absorption of Folic Acid from Different Delivery Forms: A Randomized, Crossover Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 970-970
Author(s):  
Prasad Devarshi ◽  
Ryan Grant ◽  
Meredith Wilcox ◽  
Moneka Ali ◽  
Lisa Sanders ◽  
...  
Keyword(s):  
Folic Acid ◽  
Crossover Study ◽  
Water Soluble ◽  
Serum Folate ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Maximum Serum ◽  
Study Product ◽  
To Receive ◽  
Randomized Crossover Study

Abstract Objectives Folate, or folic acid, is a water-soluble B vitamin that plays a role in single carbon transfer reactions, which are involved in the synthesis and metabolism of nucleotides and amino acids. It has been established that adequate folic acid intake helps decrease the prevalence of neural tube defects during conception and early pregnancy. The objective of this study was to assess the bioavailability of folic acid from Prenatal Multi Gummies and Folic Acid tablets in women of childbearing age. Methods Eleven healthy, adult, premenopausal women of childbearing age (18–44 years) were recruited for a single-blind, randomized, crossover study. Each participant was randomly assigned to receive a single dose (2 gummies or 2 tablets) of Prenatal Multi Gummies or Folic Acid tablets (containing ∼800 µg folic acid) and then crossed over to receive the other study product after a wash-out period of ∼7 days. The study product was consumed along with a low folic acid breakfast meal. Blood samples were collected for the analysis of serum folate at t = −0.5, 1, 2, 4, 6 and 8 hours where t = 0 is the time of study product consumption. Results The mean serum folate total area under the curve (AUC0–8 hours) was 239.67 ± 24.50 h × ng/mL for the Prenatal Multi Gummies and 255.23 ± 30.17 h × ng/mL for the Folic Acid tablets. For both study products, the dose-adjusted net incremental AUC was significantly greater than 0 h × ng/mL (P ≤ 0.001). The maximum serum folate concentration (Cmax) was 47.69 ± 5.65 ng/mL for the Prenatal Multi Gummies and 52.45 ± 5.86 ng/mL for the Folic Acid tablets, and the median time to maximum serum concentration (Tmax) was 1.00 h for each product (interquartile limits for both included 1.00 to 1.08 hours). Conclusions In conclusion, folic acid contained in the Prenatal Multi Gummies and Folic Acid tablets was absorbed from both the Prenatal Multi Gummies and the Folic Acid tablets. Funding Sources This study was funded by Pharmavite LLC.

ChemInform Abstract: Synthesis and Spectroscopic Studies of Optically Active N-Acetyl Butenoates and N-Acetyl-2-alkyl-pyrrolin-4-ones.

ChemInform ◽  
2010 ◽  
Vol 33 (27) ◽  
pp. no-no
Author(s):  
Efstathios Gavrielatos ◽  
Giorgos Athanasellis ◽  
Olga Igglessi-Markopoulou
Keyword(s):  
Spectroscopic Studies ◽  
Optically Active
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