scholarly journals Species and Density of Implant Surface Chemistry Affect the Extent of Foreign Body Reactions

Langmuir ◽  
2008 ◽  
Vol 24 (5) ◽  
pp. 2015-2024 ◽  
Author(s):  
Ashwin Nair ◽  
Ling Zou ◽  
Dhiman Bhattacharyya ◽  
Richard B. Timmons ◽  
Liping Tang
Keyword(s):  
Foreign Body ◽  
Surface Chemistry ◽  
Implant Surface ◽  
Foreign Body Reactions

Early Failure of a Polyvinyl Alcohol Hydrogel Implant With Osteolysis and Foreign Body Reactions in an Ovine Model of Cartilage Repair

2021 ◽  
pp. 036354652110336
Author(s):  
Marta Cercone ◽  
Jacqueline Chevalier ◽  
John G. Kennedy ◽  
Andrew D. Miller ◽  
Lisa A. Fortier
Keyword(s):  
Computed Tomography ◽  
Foreign Body ◽  
Polyvinyl Alcohol ◽  
Failure Rate ◽  
Synovial Membrane ◽  
Quantitative Computed Tomography ◽  
Macrophage Infiltration ◽  
Ovine Model ◽  
Foreign Body Reactions ◽  
Pva Hydrogel

Background: Hemiarthroplasty using a polyvinyl alcohol (PVA) hydrogel synthetic implant has been suggested as a good alternative to arthrodesis for the treatment of hallux rigidus. However, failure rates as high as 20% have been recorded. Purpose: To characterize the pathological processes in bone, cartilage, and the synovial membrane after PVA hemiarthroplasty in an ovine model with 6 months of follow-up. Study Design: Controlled laboratory study. Methods: A unilateral osteochondral defect (8-mm diameter × 10-mm depth) was made in the medial femoral condyle in 6 sheep. Animals were randomized to receive a PVA implant (n = 4) or to have an empty defect (n = 2) and were monitored for 6 months. Patellofemoral radiographs were obtained at monthly intervals, and quantitative computed tomography was performed at the end of the study. After death, the joints were macroscopically evaluated and scored. Osteochondral and synovial membrane histological findings were assessed using modified Osteoarthritis Research Society International (OARSI) and aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL) scoring systems. Immunohistochemistry using Iba1 was performed to evaluate activated macrophage infiltration. Results: Overall, 2 sheep with PVA implants were euthanized at 1 and 5 months because of uncontrollable pain and lameness (failed implants). Quantitative computed tomography showed that sheep with failed implants had 2.1-fold more osteolysis than those with successful implants. The sheep with failed implants had osteoarthritis with extensive glycosaminoglycan loss and cartilage fibrillation of the condyle and opposing tibial surface on histological examination. A foreign body reaction with severe chronic lymphoplasmacytic and granulomatous inflammation with giant cells was detected surrounding the implant. The synovial membrane ALVAL score was 9 of 19 and 14 of 19 in failed implants with synovial hyperplasia and lymphoplasmacytic and macrophage infiltration. In contrast, the synovial membrane in successful implants and empty defects was normal (ALVAL score = 0/19). Immunolabeling for Iba1 in failed implants confirmed extensive and dense macrophage infiltration within the condyle and synovial membrane, with the highest immunoreactive score (9/9). Conclusion: PVA hydrogel implants had a 50% failure rate with uncontrollable pain, severe osteolysis, inflammation, and foreign body reactions. Clinical Relevance: The failure rate and pathological characteristics of the PVA implants suggest that their use should not be continued in human patients without further in vivo safety studies.

Experimental oral foreign body reactions

1990 ◽  
Vol 69 (6) ◽  
pp. 713-719 ◽  
Author(s):  
Carol M. Stewart ◽  
Ronald E. Watson
Keyword(s):  
Foreign Body ◽  
Foreign Body Reactions

scholarly journals Uncommon Foreign Body Reactions Occurring in the Lip: Clinical Misdiagnosis and the Use of Special Techniques of Analysis

2010 ◽  
Vol 5 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Adriele Ferreira Gouvêa ◽  
João Adolfo Costa Hanemann ◽  
Alessandro Antonio Costa Pereira ◽  
Ana Carolina Prado Ribeiro ◽  
Mário José Romañach ◽  
...  
Keyword(s):  
Foreign Body ◽  
Foreign Body Reactions

Surgical Wound Complications after Knee Cruciate Ligament Reconstruction in Patients with Atopic Dermatitis

2020 ◽  
Author(s):  
Takuji Yokoe ◽  
Takuya Tajima ◽  
Nami Yamaguchi ◽  
Yudai Morita ◽  
Etsuo Chosa
Keyword(s):  
Atopic Dermatitis ◽  
Foreign Body ◽  
Ligament Reconstruction ◽  
Cruciate Ligament ◽  
Wound Complications ◽  
Surgical Wound ◽  
Barrier Dysfunction ◽  
Suture Materials ◽  
Cruciate Ligament Reconstruction ◽  
Foreign Body Reactions

AbstractAtopic dermatitis (AD), sometimes referred to as eczema, is a common skin disease, and skin barrier dysfunction and immunological disorders are well recognized. However, surgical wound complications after orthopaedic surgery in patients with AD have not been described. This study aimed to report four patients with AD who developed foreign body reactions to FiberWire sutures with or without surgical wound infection (SSI) after knee cruciate ligament reconstruction (CLR). The mean age was 19.8 (range, 16–25) years, and patients 1 and 3 underwent reconstructions of the posterior and anterior cruciate ligament, respectively. At a mean of 7.5 (range, 4–10) weeks postoperatively, discharge from the surgical wound at the tibial side of the fixed graft was identified. All patients were treated with continuous saline lavage and antibiotics; however, their wounds did not heal. Second-look arthroscopy and hardware removal were performed at a mean 12.2 (range, 9–15) months postoperatively. Proliferated granulation tissue surrounding the FiberWire was identified. Intraoperative wound cultures were negative in three of the four patients. Histological examination of the tissues adjacent to the FiberWire revealed a foreign body reaction. All wounds healed immediately after the second surgery. In addition to SSI, foreign body reactions are more likely to occur in patients with AD than in those without AD. Preoperative management of AD by dermatologists and consideration of appropriate suture materials are mandatory to reduce surgical wound complications after knee CLR in patients with AD.

Foreign body reactions may not influence the keloid recurrence

2015 ◽  
Vol 15 (1) ◽  
pp. 78-81
Author(s):  
Tae Hwan Park ◽  
Boram Lee ◽  
Ji Hae Park ◽  
Dong Kyun Rah
Keyword(s):  
Foreign Body ◽  
Foreign Body Reactions

scholarly journals Bovine Onchocerciasis Caused by Onchocerca armillata and O. gutturosa

1978 ◽  
Vol 15 (4) ◽  
pp. 495-505 ◽  
Author(s):  
A. H. Cheema ◽  
B. Ivoghli
Keyword(s):  
Foreign Body ◽  
Connective Tissue ◽  
Plasma Cells ◽  
Giant Cells ◽  
Tissue Reaction ◽  
Foreign Body Reactions ◽  
Gross Lesions ◽  
Acute Changes

Onchocerca armillata was found in 284 (28%) of 1,016 aortas, and O. gutturosa in 82 (28.87%) of 284 nuchal ligaments and in 11 (7.85%) of 140 rumenosplenic areas in specimens from cattle slaughtered during a 12-month period. Adult parasites were not found in 600 hides. Gross lesions included parasitic tunnels, nodules, roughening and calcification in the aortic walls. The connective tissue of nuchal ligaments and rumenosplenic areas was increased in amount, was gelatinous and brown and had a few nodules. Microscopically there were acute changes with oedema, haemorrhages and cellular infiltrations predominantly by eosinophils. There were chronic granulomatous reactions characterized by accumulation of macrophages, lymphocytes, plasma cells, giant cells, calcification and fibrosis around degenerate and dead parasites. Neutral fat was in parasites and surrounding cells. Both changes often occurred in the same specimen and many samples had parasites but no tissue reaction. Hypersensitivity, foreign-body reactions and parasitic toxins apparently were involved in the genesis of these lesions.

Sign in / Sign up

Export Citation Format

Share Document