Synergistic Antibacterial Brilliant Blue/Reduced Graphene Oxide/Quaternary Phosphonium Salt Composite with Excellent Water Solubility and Specific Targeting Capability

Langmuir ◽  
2011 ◽  
Vol 27 (12) ◽  
pp. 7828-7835 ◽  
Author(s):  
Xiang Cai ◽  
Shaozao Tan ◽  
Minsong Lin ◽  
Agui Xie ◽  
Wenjie Mai ◽  
...  
2012 ◽  
Vol 455-456 ◽  
pp. 696-700
Author(s):  
Ai Li Yu ◽  
Min Song Lin ◽  
Agui Xie ◽  
Xiang Cai ◽  
Shao Zao Tan ◽  
...  

π stacking and water-solubility of brilliant blue (BB) are expected to facilitate the hydrazine mediated reduction of graphene oxide (GO) in aqueous environment. Our newly-obtained BB-functionalized reduced graphene oxide (BB-rGO) exhibited excellent solubility and stability in water. The properties of BB-rGO were investigated. The results showed that the BB molecules stacked non-covalently onto the basal plane of rGO by strong π-π interactions while the sulfo groups of BB prevented the rGO from aggregation by electrostatic and steric repulsions, therefore leading to the solubility and stability of BB-rGO in aqueous dispersion.


2012 ◽  
Vol 455-456 ◽  
pp. 696-700
Author(s):  
Ai Li Yu ◽  
Min Song Lin ◽  
Agui Xie ◽  
Xiang Cai ◽  
Shao Zao Tan ◽  
...  

2019 ◽  
Vol 19 (6) ◽  
pp. 3544-3550 ◽  
Author(s):  
Jutamas Ampaiwong ◽  
Pranee Rattanawaleedirojn ◽  
Kanokwan Saengkiettiyut ◽  
Nadnudda Rodthongkum ◽  
Pranut Potiyaraj ◽  
...  

Herein, carboxymethyl cellulose nanocomposite films incorporated with graphene oxide and reduced graphene oxide were successfully prepared by a novel approach for the first time, and their alternative properties compared with the original carboxymethyl cellulose films were disclosed. For carboxymethyl cellulose/reduced graphene oxide film preparation, sodium borohydride was used as a chemical reducing agent. The carboxymethyl cellulose films were prepared by using a solvent casting method, followed by an acid treatment to decrease the water solubility (98%) while enhancing the tensile strength (15%) and elastic modulus (32%) of the original carboxymethyl cellulose films. Overall, the addition of 1.0 wt% graphene oxide and reduced graphene oxide to the treated films increased the water solubility, water absorption, tensile properties and electrical conductivity. Particularly, the electrical conductivity was predominantly enhanced 1.3×105 times with graphene oxide and 2.2×105 times with reduced graphene oxide compared to the treated carboxymethyl cellulose film. The electrical conductivity of the treated carboxymethyl cellulose film also increased with an increase in reduced graphene oxide. The effects of reduced graphene oxide on the water solubility, water absorption, tensile properties and electrical conductivity of the treated carboxymethyl cellulose film were more pronounced than those of graphene oxide, especially for the electrical conductivity. In conclusion, graphene oxide and reduced graphene oxide might be alternative nanofillers for improving the carboxymethyl cellulose film properties. For the future applications, carboxymethyl cellulose/reduced graphene oxide films prepared by using this approach might be employed as alternative materials in electronic packagings and electrochemical biosensors.


Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1957
Author(s):  
Chia-Hua Lin ◽  
Yi-Chun Chen ◽  
Pin-I. Huang

The present study aimed to develop a multifunctional nanoparticle platform with properties that are beneficial in imaging, targeting, and synergistic cancer phototherapy. To this end, we synthesized novel nanoparticles composed of polydopamine, nano zero-valent iron (nZVI), and reduced graphene oxide (rGO). We immobilized nZVI on the surface of GO (nZVI/GO), then further modified nZVI/GO with dopamine to form polydopamine-conjugated nZVI/rGO (nZVI/rGO@pDA). Because nZVI/rGO@pDA absorbs near infrared radiation (NIR) and binds biomolecules of cancer cells, this platform is highly efficacious in photothermal and photodynamic cancer therapy and enables specific targeting of breast cancer cells. Use of nZVI/rGO@pDA at a low concentration (10 μg/mL) resulted in irreversible damage to MCF-7 cells under NIR irradiation (808 nm) without inducing cytotoxic effects in normal cells. Furthermore, nZVI/rGO@pDA showed high sensitivity in magnetic resonance imaging (MRI), comparable to nZVI@pDA, even at low concentration. Monitoring the treatment response through evaluation of MRI signal intensity of nZVI/rGO@pDA in phototherapeutic therapy revealed that the novel material combines the advantages of nZVI, rGO, and pDA to provide specific targeting capabilities, excellent biocompatibility, and cancer phototherapeutic and tumor imaging abilities. Thus, this platform offers great potential in terms of imaging and therapeutic effects in phototherapy treatment for breast cancer.


2020 ◽  
Author(s):  
Christos E. Athanasiou ◽  
Mok Yun Jin ◽  
Cristina Ramirez ◽  
Nitin P. Padture ◽  
Brian W. Sheldon

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