scholarly journals Preparation of Multifunctional Dopamine-Coated Zerovalent Iron/Reduced Graphene Oxide for Targeted Phototheragnosis in Breast Cancer

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1957
Author(s):  
Chia-Hua Lin ◽  
Yi-Chun Chen ◽  
Pin-I. Huang
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Cancer Cells ◽  
Reduced Graphene Oxide ◽  
Tumor Imaging ◽  
Zerovalent Iron ◽  
Therapeutic Effects ◽  
Low Concentration ◽  
Specific Targeting ◽  
Reduced Graphene

The present study aimed to develop a multifunctional nanoparticle platform with properties that are beneficial in imaging, targeting, and synergistic cancer phototherapy. To this end, we synthesized novel nanoparticles composed of polydopamine, nano zero-valent iron (nZVI), and reduced graphene oxide (rGO). We immobilized nZVI on the surface of GO (nZVI/GO), then further modified nZVI/GO with dopamine to form polydopamine-conjugated nZVI/rGO (nZVI/rGO@pDA). Because nZVI/rGO@pDA absorbs near infrared radiation (NIR) and binds biomolecules of cancer cells, this platform is highly efficacious in photothermal and photodynamic cancer therapy and enables specific targeting of breast cancer cells. Use of nZVI/rGO@pDA at a low concentration (10 μg/mL) resulted in irreversible damage to MCF-7 cells under NIR irradiation (808 nm) without inducing cytotoxic effects in normal cells. Furthermore, nZVI/rGO@pDA showed high sensitivity in magnetic resonance imaging (MRI), comparable to nZVI@pDA, even at low concentration. Monitoring the treatment response through evaluation of MRI signal intensity of nZVI/rGO@pDA in phototherapeutic therapy revealed that the novel material combines the advantages of nZVI, rGO, and pDA to provide specific targeting capabilities, excellent biocompatibility, and cancer phototherapeutic and tumor imaging abilities. Thus, this platform offers great potential in terms of imaging and therapeutic effects in phototherapy treatment for breast cancer.

Optimizing the hybrid nanostructure of functionalized reduced graphene oxide/silver for highly efficient cancer nanotherapy

2018 ◽  
Vol 42 (15) ◽  
pp. 13157-13168 ◽  
Author(s):  
Hossein Golzar ◽  
Fatemeh Yazdian ◽  
Mohadeseh Hashemi ◽  
Meisam Omidi ◽  
Dorsa Mohammadrezaei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Cancer Cells ◽  
Reduced Graphene Oxide ◽  
Breast Cancer Cells ◽  
Hybrid Nanostructure ◽  
Her2 Positive ◽  
Her2 Positive Breast Cancer ◽  
Reduced Graphene ◽  
Positive Breast Cancer

Conjugation of Herceptin to the surface of an optimized rGO-PLL/AgNP nanohybrid to achieve an efficient targeted DDS against Her2 positive breast cancer cells.

scholarly journals Enhanced Apoptosis by Functionalized Highly Reduced Graphene Oxide and Gold Nanocomposites in MCF-7 Breast Cancer Cells

ACS Omega ◽  
2021 ◽  
Author(s):  
Syed Farooq Adil ◽  
Mohammed Rafi Shaik ◽  
Fahd A. Nasr ◽  
Ali S. Alqahtani ◽  
Mohammad Z. Ahmed ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Cancer Cells ◽  
Reduced Graphene Oxide ◽  
Breast Cancer Cells ◽  
Reduced Graphene ◽  
Gold Nanocomposites ◽  
Mcf 7

scholarly journals The Preliminary Study on the Proapoptotic Effect of Reduced Graphene Oxide in Breast Cancer Cell Lines

2021 ◽  
Vol 22 (22) ◽  
pp. 12593
Author(s):  
Rafał Krętowski ◽  
Agata Jabłońska-Trypuć ◽  
Marzanna Cechowska-Pasko
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Graphene Oxide ◽  
Cancer Cells ◽  
Reduced Graphene Oxide ◽  
Cell Lines ◽  
Breast Cancer Cell ◽  
Breast Cancer Cells ◽  
Breast Cancer Cell Lines ◽  
Reduced Graphene

Breast cancer is the most common cancer diagnosed in women, however traditional therapies have several side effects. This has led to an urgent need to explore novel drug approaches to treatment strategies such as graphene-based nanomaterials such as reduced graphene oxide (rGO). It was noticed as a potential drug due to its target selectivity, easy functionalisation, chemisensitisation, and high drug-loading capacity. rGO is widely used in many fields, including biological and biomedical, due to its unique physicochemical properties. However, the possible mechanisms of rGO toxicity remain unclear. In this paper, we present findings on the cytotoxic and antiproliferative effects of rGO and its ability to induce oxidative stress and apoptosis of breast cancer cell lines. We indicate that rGO induced time- and dose-dependent cytotoxicity in MDA-MB-231 and ZR-75-1 cell lines, but not in T-47D, MCF-7, Hs 578T cell lines. In rGO-treated MDA-MB-231 and ZR-75-1 cell lines, we noticed increased induction of apoptosis and necrosis. In addition, rGO has been found to cause oxidative stress, reduce proliferation, and induce structural changes in breast cancer cells. Taken together, these studies provide new insight into the mechanism of oxidative stress and apoptosis in breast cancer cells.

Curcumin-reduced graphene oxide sheets and their effects on human breast cancer cells

2015 ◽  
Vol 55 ◽  
pp. 482-489 ◽  
Author(s):  
Shadie Hatamie ◽  
Omid Akhavan ◽  
Sayed Khatiboleslam Sadrnezhaad ◽  
Mohammad Mahdi Ahadian ◽  
Mandar M. Shirolkar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Cancer Cells ◽  
Reduced Graphene Oxide ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Reduced Graphene ◽  
Graphene Oxide Sheets

scholarly journals Facile fabrication of nano zerovalent iron – Reduced graphene oxide composites for nitrate reduction in water

2021 ◽  
Vol 3 ◽  
pp. 100024
Author(s):  
J.U. Halpegama ◽  
P.M.C.J. Bandara ◽  
L. Jayarathna ◽  
A. Bandara ◽  
Chen-Yu Yeh ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Nitrate Reduction ◽  
Zerovalent Iron ◽  
Reduced Graphene ◽  
Nano Zerovalent Iron ◽  
Facile Fabrication ◽  
Oxide Composites
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