Hydrophilic Composite Elastomeric Mold for High-Resolution Soft Lithography

Langmuir ◽  
2006 ◽  
Vol 22 (21) ◽  
pp. 9018-9022 ◽  
Author(s):  
Nae Yoon Lee ◽  
Ju Ri Lim ◽  
Min Jung Lee ◽  
Jong Bok Kim ◽  
Sung Jin Jo ◽  
...  
Keyword(s):  
High Resolution ◽  
Soft Lithography

scholarly journals Micromechanical Punching: A Versatile Method for Non-Spherical Microparticle Fabrication

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 83
Author(s):  
Ritika Singh Petersen ◽  
Anja Boisen ◽  
Stephan Sylvest Keller
Keyword(s):  
Drug Delivery ◽  
High Resolution ◽  
Physicochemical Properties ◽  
High Throughput ◽  
Liquid State ◽  
Soft Lithography ◽  
Glycolic Acid ◽  
Thermosetting Polymers ◽  
Spherical Microparticle ◽  
Spherical Microparticles

Microparticles are ubiquitous in applications ranging from electronics and drug delivery to cosmetics and food. Conventionally, non-spherical microparticles in various materials with specific shapes, sizes, and physicochemical properties have been fabricated using cleanroom-free lithography techniques such as soft lithography and its high-resolution version particle replication in non-wetting template (PRINT). These methods process the particle material in its liquid/semi-liquid state by deformable molds, limiting the materials from which the particles and the molds can be fabricated. In this study, the microparticle material is exploited as a sheet placed on a deformable substrate, punched by a robust mold. Drawing inspiration from the macro-manufacturing technique of punching metallic sheets, Micromechanical Punching (MMP) is a high-throughput technique for fabrication of non-spherical microparticles. MMP allows production of microparticles from prepatterned, porous, and fibrous films, constituting thermoplastics and thermosetting polymers. As an illustration of application of MMP in drug delivery, flat, microdisk-shaped Furosemide embedded poly(lactic-co-glycolic acid) microparticles are fabricated and Furosemide release is observed. Thus, it is shown in the paper that Micromechanical punching has potential to make micro/nanofabrication more accessible to the research and industrial communities active in applications that require engineered particles.

High-Resolution Soft Lithography: Enabling Materials for Nanotechnologies

2004 ◽  
Vol 116 (43) ◽  
pp. 5920-5923 ◽  
Author(s):  
Jason P. Rolland ◽  
Erik C. Hagberg ◽  
Ginger M. Denison ◽  
Kenneth R. Carter ◽  
Joseph M. De Simone
Keyword(s):  
High Resolution ◽  
Soft Lithography

Novel Silicon-Elastomers for Advanced Soft Lithography

2006 ◽  
Vol 947 ◽  
Author(s):  
Kyung Choi
Keyword(s):  
Thermal Expansion ◽  
High Resolution ◽  
Soft Lithography ◽  
Materials Properties ◽  
Nano Scale ◽  
Thermal Expansion Coefficients ◽  
High Thermal Expansion ◽  
Expansion Coefficients

ABSTRACTHigh resolution pattern transfers in the nano-scale regime have been considerable challenges in ‘soft lithography’ to achieve nanodevices with enhanced performances. In this technology, the resolution of pattern integrations is significantly rely on the materials' properties of polydimethylsiloxane (PDMS) stamps. Since commercial PDMS stamps have shown limitations in nano-scale resolution soft lithography due to their low physical toughness and high thermal expansion coefficients, we developed stiffer, photocured PDMS silicon elastomers designed, specifically for nano-sized soft lithography and photopatternable nanofabrications.

scholarly journals Rapid and Inexpensive Fabrication of Multi-Depth Microfluidic Device using High-Resolution LCD Stereolithographic 3D Printing

2019 ◽  
Vol 3 (1) ◽  
pp. 26 ◽  
Author(s):  
Mohamed Mohamed ◽  
Hitendra Kumar ◽  
Zongjie Wang ◽  
Nicholas Martin ◽  
Barry Mills ◽  
...  
Keyword(s):  
High Resolution ◽  
3D Printing ◽  
Soft Lithography ◽  
Liquid Crystal Display ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Single Step ◽  
Droplet Generator ◽  
Rapid Fabrication ◽  
Printing System

With the dramatic increment of complexity, more microfluidic devices require 3D structures, such as multi-depth and -layer channels. The traditional multi-step photolithography is time-consuming and labor-intensive and also requires precise alignment during the fabrication of microfluidic devices. Here, we present an inexpensive, single-step, and rapid fabrication method for multi-depth microfluidic devices using a high-resolution liquid crystal display (LCD) stereolithographic (SLA) three-dimensional (3D) printing system. With the pixel size down to 47.25 μm, the feature resolutions in the horizontal and vertical directions are 150 μm and 50 μm, respectively. The multi-depth molds were successfully printed at the same time and the multi-depth features were transferred properly to the polydimethylsiloxane (PDMS) having multi-depth channels via soft lithography. A flow-focusing droplet generator with a multi-depth channel was fabricated using the presented 3D printing method. Experimental results show that the multi-depth channel could manipulate the morphology and size of droplets, which is desired for many engineering applications. Taken together, LCD SLA 3D printing is an excellent alternative method to the multi-step photolithography for the fabrication of multi-depth microfluidic devices. Taking the advantages of its controllability, cost-effectiveness, and acceptable resolution, LCD SLA 3D printing can have a great potential to fabricate 3D microfluidic devices.

Siloxane Polymers for High-Resolution, High-Accuracy Soft Lithography

2000 ◽  
Vol 33 (8) ◽  
pp. 3042-3049 ◽  
Author(s):  
H. Schmid ◽  
B. Michel
Keyword(s):  
High Resolution ◽  
Soft Lithography ◽  
High Accuracy ◽  
Siloxane Polymers

scholarly journals Stem cell behaviors on periodic arrays of nanopillars analyzed by high-resolution scanning electron microscope images

2020 ◽  
Vol 50 (1) ◽  
Author(s):  
Jihun Kang ◽  
Eun-Hye Kang ◽  
Young-Shik Yun ◽  
Seungmuk Ji ◽  
In-Sik Yun ◽  
...  
Keyword(s):  
Electron Microscope ◽  
High Resolution ◽  
Scanning Electron Microscope ◽  
Soft Lithography ◽  
Accurate Analysis ◽  
Cell Behaviors ◽  
Periodic Arrays ◽  
Crucial Information ◽  
High Resolution Images ◽  
Scanning Electron

AbstractThe biocompatible polyurethane acrylate (PUA) nanopillars were fabricated by soft lithography using three different sizes of nanobeads (350, 500, and 1000 nm), and the human adipose-derived stem cells (hASCs) were cultured on the nanopillars. The hASCs and their various behaviors, such as cytoplasmic projections, migration, and morphology, were observed by high resolution images using a scanning electron microscope (SEM). With the accurate analysis by SEM for the controlled sizes of nanopillars, the deflections are observed at pillars fabricated with 350- and 500-nm nanobeads. These high-resolution images could offer crucial information to elucidate the complicated correlations between nanopillars and the cells, such as morphology and cytoplasmic projections.

scholarly journals Cheap, Versatile, and Turnkey Fabrication of Microfluidic Master Molds Using Consumer Grade LCD Stereolithography 3D Printing

2021 ◽  
Author(s):  
Vincent G. Colin ◽  
Théo A. Travers ◽  
Denis Gindre ◽  
Régis Barillé ◽  
Matthieu Loumaigne
Keyword(s):  
High Resolution ◽  
3D Printing ◽  
Cost Efficiency ◽  
Soft Lithography ◽  
Microfluidic Devices ◽  
Teaching Tool ◽  
3D Printer ◽  
Uv Led ◽  
Led Array ◽  
3D Printers

Abstract The recent development of 3D printers allowed a lot of limitations in the field of microfabrication to be circumvented. The ever-growing chase for smaller dimensions has come to an end in domains such as microfluidics, and the focus now shifted to a cost-efficiency challenge. In this paper, the use of a high-resolution stereolithography LCD 3D printer is investigated for fast and cheap production of microfluidic master molds. More precisely, we use the UV LED array and the LCD matrix of the printer as an illuminator and a programmable photomask for soft lithography. The achieved resolution of around 100µm is mainly limited by the pixel geometry of the LCD matrix. A tree-shape gradient mixer was fabricated using the presented method. It shows very good performances despite the presence of sidewall ripples due to the uneven pixel geometry of the LCD matrix. Given its sub-€1,000 cost, this method is a very good entry point for labs wishing to explore the potential of microfluidic devices in their experiments, as well as a teaching tool for introducing students to microfluidics.

scholarly journals Paper-Thin Multilayer Microfluidic Devices with Integrated Valves

2020 ◽  
Author(s):  
Soohong Kim ◽  
Gabriel Dorlhiac ◽  
Rodrigo Cotrim Chaves ◽  
Mansi Zalavadia ◽  
Aaron Streets
Keyword(s):  
High Resolution ◽  
Raman Scattering ◽  
Soft Lithography ◽  
Stimulated Raman Scattering ◽  
Single Cells ◽  
Microfluidic Devices ◽  
Fluorescent Imaging ◽  
Cover Glass ◽  
On Chip ◽  
Stimulated Raman

Integrated valve microfluidics has an unparalleled capability to automate the rapid delivery of fluids at the nanoliter scale for high-throughput biological experimentation. However, multilayer soft lithography, which is used to fabricate valve-microfluidics, produces devices with a minimum thickness of around five millimeters. This form-factor limitation prevents the use of such devices in experiments with limited sample thickness tolerance such as 4-pi microscopy, stimulated Raman scattering microscopy, and many forms of optical or magnetic tweezer applications. We present a new generation of integrated valve microfluidic devices that are less than 300 μm thick, including the cover-glass substrate, that resolves the thickness limitation. This "thin-chip" was fabricated through a novel soft-lithography technique that produces on-chip micro-valves with the same functionality and reliability of traditional thick valve-microfluidic devices despite the orders of magnitude reduction in thickness. We demonstrated the advantage of using our thin-chip over traditional thick devices to automate fluid control while imaging on a high-resolution inverted microscope. First, we demonstrate that the thin-chip provides improved signal to noise when imaging single cells with two-color stimulated Raman scattering (SRS). We then demonstrated how the thin-chip can be used to simultaneously perform on-chip magnetic manipulation of beads and fluorescent imaging. This study reveals the potential of our thin-chip in high-resolution imaging, sorting, and bead capture-based single-cell multi-omics applications.

High Resolution Separation of Proteins in a Polymeric Micro-Fluidic Chip

2003 ◽  
Author(s):  
Keisuke Horiuchi ◽  
Prashanta Dutta ◽  
Huanchun Cui ◽  
Cornelius F. Ivory
Keyword(s):  
High Resolution ◽  
Mass Production ◽  
Soft Lithography ◽  
Fluorescent Proteins ◽  
Three Dimensional ◽  
Peak Capacity ◽  
Microfluidic Chips ◽  
Sharp Edges ◽  
Separation Of Proteins ◽  
Long Channel

An integrated micro-fluidic chip has been developed using Poly-di-methyl siloxane (PDMS) to separate proteins by isoelectric focusing (IEF). Soft lithography techniques, which offer rapid prototyping, easy multilayer fabrication, mass production capability and biocompatibility, were utilized to fabricate various parts of the micro-fluidic chip. Separately molded PDMS layers were bonded together to form three-dimensional microfluidic chips. The microfluidic chips were prepared for IEF by conditioning the channel with 1 M NaOH and then loading it with a solution of fluorescent proteins made using 0.4% MC, 4% broad-range ampholyte and 0.018 mg/ml protein in 18 MOhm water. Relatively large reservoirs on the acidic and basic ends of the channel were filled with anolyte (50 mM phosphoric acid) and catholyte (50 mM sodium hydroxide), respectively, and then current was applied along the axis of the channel until one or more bands of protein focused, usually in just a few minutes even at relatively low voltages. The focused bands were generally well-formed with sharp edges and were less than 100 microns across yielding a putative peak capacity in excess of 100 peaks in a 2-cm long channel.

Titelbild: High-Resolution Soft Lithography: Enabling Materials for Nanotechnologies (Angew. Chem. 43/2004)

2004 ◽  
Vol 116 (43) ◽  
pp. 5827-5827 ◽  
Author(s):  
Jason P. Rolland ◽  
Erik C. Hagberg ◽  
Ginger M. Denison ◽  
Kenneth R. Carter ◽  
Joseph M. De Simone
Keyword(s):  
High Resolution ◽  
Soft Lithography
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