Aggregation of Colloidal Particles in the Presence of Oppositely Charged Polyelectrolytes:  Effect of Surface Charge Heterogeneities

Langmuir ◽  
2001 ◽  
Vol 17 (17) ◽  
pp. 5225-5231 ◽  
Author(s):  
Frederic Bouyer ◽  
Andrea Robben ◽  
Wei Li Yu ◽  
Michal Borkovec
Keyword(s):  
Surface Charge ◽  
Colloidal Particles ◽  
Oppositely Charged ◽  
Effect Of Surface

Multilayers of Oppositely Charged SiO2Nanoparticles:  Effect of Surface Charge on Multilayer Assembly

Langmuir ◽  
2007 ◽  
Vol 23 (17) ◽  
pp. 8833-8837 ◽  
Author(s):  
Daeyeon Lee ◽  
Zekeriyya Gemici ◽  
Michael F. Rubner ◽  
Robert E. Cohen
Keyword(s):  
Surface Charge ◽  
Oppositely Charged ◽  
Effect Of Surface

scholarly journals EFFECTS OF POLYMERIC NANOPARTICLE SURFACE PROPERTIES ON INTERACTION WITH BRAIN TUMOR ENVIRONMENT

Nano LIFE ◽  
2013 ◽  
Vol 03 (04) ◽  
pp. 1343003 ◽  
Author(s):  
BRANDON MATTIX ◽  
THOMAS MOORE ◽  
OLGA UVAROV ◽  
SAMUEL POLLARD ◽  
LAUREN O'DONNELL ◽  
...  
Keyword(s):  
Human Brain ◽  
Surface Charge ◽  
Cellular Uptake ◽  
Drug Clearance ◽  
Cellular Interaction ◽  
Normal Tissues ◽  
Poly Ethylene ◽  
Uptake Studies ◽  
Effect Of Surface

Current chemotherapy treatments are limited by poor drug solubility, rapid drug clearance and systemic side effects. Additionally, drug penetration into solid tumors is limited by physical diffusion barriers [e.g., extracellular matrix (ECM)]. Nanoparticle (NP) blood circulation half-life, biodistribution and ability to cross extracellular and cellular barriers will be dictated by NP composition, size, shape and surface functionality. Here, we investigated the effect of surface charge of poly(lactide)-poly(ethylene glycol) NPs on mediating cellular interaction. Polymeric NPs of equal sizes were used that had two different surface functionalities: negatively charged carboxyl ( COOH ) and neutral charged methoxy ( OCH 3). Cellular uptake studies showed significantly higher uptake in human brain cancer cells compared to noncancerous human brain cells, and negatively charged COOH NPs were uptaken more than neutral OCH 3 NPs in 2D culture. NPs were also able to load and control the release of paclitaxel (PTX) over 19 days. Toxicity studies in U-87 glioblastoma cells showed that PTX-loaded NPs were effective drug delivery vehicles. Effect of surface charge on NP interaction with the ECM was investigated using collagen in a 3D cellular uptake model, as collagen content varies with the type of cancer and the stage of the disease compared to normal tissues. Results demonstrated that NPs can effectively diffuse across an ECM barrier and into cells, but NP mobility is dictated by surface charge. In vivo biodistribution of OCH 3 NPs in intracranial tumor xenografts showed that NPs more easily accumulated in tumors with less collagen. These results indicate that a robust understanding of NP interaction with various tumor environments can lead to more effective patient-tailored therapies.

Effect of Surface Charge Density of Graphene Oxide on Chemical Warfare Agent Simulants Blocking

2021 ◽  
pp. 152225
Author(s):  
Youna Kim ◽  
Moonhyun Choi ◽  
Jiwoong Heo ◽  
Sungwon Jung ◽  
Dongwon Ka ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Charge Density ◽  
Surface Charge ◽  
Surface Charge Density ◽  
Chemical Warfare Agent ◽  
Chemical Warfare ◽  
Effect Of Surface

Induced asymmetries in the heteroaggregation of oppositely charged colloidal particles

2003 ◽  
Vol 265 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Antonio M Puertas ◽  
A Fernández-Barbero ◽  
F.J de las Nieves
Keyword(s):  
Colloidal Particles ◽  
Oppositely Charged

Effect of Surface Charge on the Uptake of Magnetic Nanoparticles in Mouse Fibroblast Cells

2017 ◽  
Vol 8 ◽  
pp. 1-5 ◽  
Author(s):  
Jefunnie S. Matahum ◽  
Chao-Ming Su ◽  
Wei-Jie Wang ◽  
Shyh-Liang Lou ◽  
Tzong-Rong Ger
Keyword(s):  
Magnetic Nanoparticles ◽  
Surface Charge ◽  
Mouse Fibroblast ◽  
Fibroblast Cells ◽  
Effect Of Surface
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