Effect of surface charge on the curvature elasticity of membranes

1988 ◽  
Vol 92 (24) ◽  
pp. 6865-6867 ◽  
Author(s):  
M. Winterhalter ◽  
W. Helfrich
Keyword(s):  
Surface Charge ◽  
Curvature Elasticity ◽  
Effect Of Surface

scholarly journals EFFECTS OF POLYMERIC NANOPARTICLE SURFACE PROPERTIES ON INTERACTION WITH BRAIN TUMOR ENVIRONMENT

Nano LIFE ◽  
2013 ◽  
Vol 03 (04) ◽  
pp. 1343003 ◽  
Author(s):  
BRANDON MATTIX ◽  
THOMAS MOORE ◽  
OLGA UVAROV ◽  
SAMUEL POLLARD ◽  
LAUREN O'DONNELL ◽  
...  
Keyword(s):  
Human Brain ◽  
Surface Charge ◽  
Cellular Uptake ◽  
Drug Clearance ◽  
Cellular Interaction ◽  
Normal Tissues ◽  
Poly Ethylene ◽  
Uptake Studies ◽  
Effect Of Surface

Current chemotherapy treatments are limited by poor drug solubility, rapid drug clearance and systemic side effects. Additionally, drug penetration into solid tumors is limited by physical diffusion barriers [e.g., extracellular matrix (ECM)]. Nanoparticle (NP) blood circulation half-life, biodistribution and ability to cross extracellular and cellular barriers will be dictated by NP composition, size, shape and surface functionality. Here, we investigated the effect of surface charge of poly(lactide)-poly(ethylene glycol) NPs on mediating cellular interaction. Polymeric NPs of equal sizes were used that had two different surface functionalities: negatively charged carboxyl ( COOH ) and neutral charged methoxy ( OCH 3). Cellular uptake studies showed significantly higher uptake in human brain cancer cells compared to noncancerous human brain cells, and negatively charged COOH NPs were uptaken more than neutral OCH 3 NPs in 2D culture. NPs were also able to load and control the release of paclitaxel (PTX) over 19 days. Toxicity studies in U-87 glioblastoma cells showed that PTX-loaded NPs were effective drug delivery vehicles. Effect of surface charge on NP interaction with the ECM was investigated using collagen in a 3D cellular uptake model, as collagen content varies with the type of cancer and the stage of the disease compared to normal tissues. Results demonstrated that NPs can effectively diffuse across an ECM barrier and into cells, but NP mobility is dictated by surface charge. In vivo biodistribution of OCH 3 NPs in intracranial tumor xenografts showed that NPs more easily accumulated in tumors with less collagen. These results indicate that a robust understanding of NP interaction with various tumor environments can lead to more effective patient-tailored therapies.

Effect of Surface Charge Density of Graphene Oxide on Chemical Warfare Agent Simulants Blocking

2021 ◽  
pp. 152225
Author(s):  
Youna Kim ◽  
Moonhyun Choi ◽  
Jiwoong Heo ◽  
Sungwon Jung ◽  
Dongwon Ka ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Charge Density ◽  
Surface Charge ◽  
Surface Charge Density ◽  
Chemical Warfare Agent ◽  
Chemical Warfare ◽  
Effect Of Surface

Effect of Surface Charge on the Uptake of Magnetic Nanoparticles in Mouse Fibroblast Cells

2017 ◽  
Vol 8 ◽  
pp. 1-5 ◽  
Author(s):  
Jefunnie S. Matahum ◽  
Chao-Ming Su ◽  
Wei-Jie Wang ◽  
Shyh-Liang Lou ◽  
Tzong-Rong Ger
Keyword(s):  
Magnetic Nanoparticles ◽  
Surface Charge ◽  
Mouse Fibroblast ◽  
Fibroblast Cells ◽  
Effect Of Surface

scholarly journals Effect of Surface Charge on the Cellular Uptake and Cytotoxicity of Fluorescent Labeled Cellulose Nanocrystals

2010 ◽  
Vol 2 (10) ◽  
pp. 2924-2932 ◽  
Author(s):  
Khaled A. Mahmoud ◽  
Jimmy A. Mena ◽  
Keith B. Male ◽  
Sabahudin Hrapovic ◽  
Amine Kamen ◽  
...  
Keyword(s):  
Surface Charge ◽  
Cellular Uptake ◽  
Cellulose Nanocrystals ◽  
Effect Of Surface

scholarly journals Effect of surface charge of gold nanoparticles on fluorescence amplification of polydiacetylene-based liposomes

2020 ◽  
Vol 15 (1) ◽  
pp. 174-181
Author(s):  
Kyu Ha Park ◽  
Sangjin Oh ◽  
Jeonghyo Kim ◽  
Seung Yun Yang ◽  
Beum-Soo An ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Surface Charge ◽  
Fluorescence Amplification ◽  
Effect Of Surface

Study on Polarization and Adhesion Property of Gecko Inspired Mushroom-Shaped Pillars

2020 ◽  
Vol 1013 ◽  
pp. 19-24
Author(s):  
Ming Yue Lu ◽  
Yang Li ◽  
Qing Song He ◽  
Zhen Dong Dai
Keyword(s):  
Chemical Composition ◽  
Surface Charge ◽  
High Voltage ◽  
Negative Charge ◽  
Biological Tissues ◽  
Adhesion Property ◽  
Positive Electrode ◽  
Adhesion Performance ◽  
Effect Of Surface ◽  
Adhesive Materials

Geckos can run swiftly on various surfaces, is not only related to the micro-nanostructure of their setae, but also related to the charged keratin in biological tissues of epidermis. Many gecko-inspired structural materials have been developed in order to obtain desired adhesion property. Much research has been done to improve their adhesion by changing chemical composition and optimizing micro-nanostructure, but little research has been done on the effect of surface charge. Therefore, this study aims to investigate the effect of surface charge on the adhesion of gecko-inspired materials, and to explore a new way to improve their adhesion performance. In this work, the dry adhesive materials made of polyvinylsiloxane (PVS) with mushroom-shaped pillars were polarized under high voltage. The results showed that polarized samples with the mushroom-shaped pillars facing the positive electrode have more negative charge, and the adhesion was improved a lot with increasing charge.

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