Characterization of Impurities Formed by Interaction of Duloxetine HCl with Enteric Polymers Hydroxypropyl Methylcellulose Acetate Succinate and Hydroxypropyl Methylcellulose Phthalate

1998 ◽  
Vol 87 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Patrick J. Jansen ◽  
Peter L. Oren ◽  
Craig A. Kemp ◽  
Steven R. Maple ◽  
Steven W. Baertschi
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Enteric Polymers ◽  
Hydroxypropyl Methylcellulose Phthalate

scholarly journals NOVEL APPROACH OF EXTRACTION AND CHARACTERIZATION OF OKRA GUM AS A BINDER FOR TABLET FORMULATION

2019 ◽  
Vol 12 (1) ◽  
pp. 189
Author(s):  
Shayeri Chatterjee ◽  
Rana Mazumder
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Scanning Calorimetry ◽  
Swelling Properties ◽  
Novel Approach ◽  
Coated Tablet ◽  
Present Aspect ◽  
Tablet Formulations ◽  
Okra Gum ◽  
The Fourier Transform

Objective: The major objective of the present investigation was to extract a natural polymer (okra gum) with its characterization as pharmaceutical binder and to formulate, develop, and evaluate the compression-coated tablet using okra as binder along with synthetic hydrophilic polymers like various grades of hydroxypropyl methylcellulose (HPMC).Methods: A novel extraction method was carried out using fresh unripe pods of okra (ladies finger) with the aid of organic solvents and its characterization was done. The core tablets were prepared by direct compression method which was compression coated with okra gum and HPMC.Results: After the extraction of the okra gum was carried out, the yield of mucilage obtained was 10%. It is considered as a proof for the purity of the mucilage extract. The above study reveals that the polymers were subjected to the Fourier transform infrared and differential scanning calorimetry thermogram had no significant interactions between the drug and the polymers. The characterization of the new polymer okra showed that it has swelling properties, and in spite of being a hydrophilic polymer, it can be successfully used in pharmaceutical formulation as a good binder.Conclusion: In the present aspect of the study was to evaluate the efficacy of okra gum that has been used as a tablet binder. It is easily available and inexpensive. Okra gum as a binder produces tablet formulations with good physicochemical properties and good candidate for sustained release formulations.

Characterization of pH-sensitive chitosan/hydroxypropyl methylcellulose composite nanoparticles for delivery of melatonin in cancer therapy

2021 ◽  
Vol 282 ◽  
pp. 128818
Author(s):  
Hessam Jafari ◽  
Mehdi Hassanpour ◽  
Ali Akbari ◽  
Jafar Rezaie ◽  
Gholamreza Gohari ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Hydroxypropyl Methylcellulose ◽  
Ph Sensitive ◽  
Composite Nanoparticles

scholarly journals Preparation and Characterization of Hydroxypropyl Methylcellulose/Polycarbophil Mucoadhesive Blend Films Using a Mixture Design Approach

2017 ◽  
Vol 65 (3) ◽  
pp. 284-294 ◽  
Author(s):  
Pakorn Kraisit ◽  
Sontaya Limmatvapirat ◽  
Jurairat Nunthanid ◽  
Pornsak Sriamornsak ◽  
Manee Luangtana-Anan
Keyword(s):  
Hydroxypropyl Methylcellulose ◽  
Mixture Design ◽  
Design Approach ◽  
Blend Films

scholarly journals Preparation and Characterization of HPMC/PVP Blend Films Plasticized with Sorbitol

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
H. Somashekarappa ◽  
Y. Prakash ◽  
K. Hemalatha ◽  
T. Demappa ◽  
R. Somashekar
Keyword(s):  
Mechanical Properties ◽  
Hydroxypropyl Methylcellulose ◽  
Solution Casting ◽  
Casting Method ◽  
Elongation At Break ◽  
X Ray ◽  
Blend Films ◽  
X Ray Scattering ◽  
Solution Casting Method

The aim of this present work is to investigate the effect of plasticizers like Sorbitol on microstructural and mechanical properties of hydroxypropyl methylcellulose (HPMC) and Polyvinylpyrrolidone (PVP) blend films. The pure blend and plasticized blend films were prepared by solution casting method and investigated using wide angle X-ray scattering (WAXS) method. WAXS analysis confirms that the plasticizers can enter into macromolecular blend structure and destroy the crystallinity of the films. FTIR spectra show that there are a shift and decrease in the intensity of the peaks confirming the interaction of plasticizer with the blend. Mechanical properties like tensile strength and Young’s Modulus decrease up to 0.6% of Sorbitol content in the films. Percentage of elongation at break increases suggesting that the plasticized films are more flexible than pure blend films. These films are suitable to be used as environmental friendly and biodegradable packaging films.

Sign in / Sign up

Export Citation Format

Share Document