DNA Binding by Fagaronine and Ethoxidine, Inhibitors of Human DNA Topoisomerases I and II, Probed by SERS and Flow Linear Dichroism Spectroscopy†

1999 ◽  
Vol 103 (11) ◽  
pp. 2008-2013 ◽  
Author(s):  
Anatoli Ianoul ◽  
Fabrice Fleury ◽  
Olivier Duval ◽  
Roger Waigh ◽  
Jean-Claude Jardillier ◽  
...  
Keyword(s):  
Dna Binding ◽  
Linear Dichroism ◽  
Dna Topoisomerases ◽  
Human Dna

Antitumor Effect of Pomolic Acid in Acute Myeloid Leukemia Cells Involves Cell Death, Decreased Cell Growth and Topoisomerases Inhibition

2019 ◽  
Vol 18 (10) ◽  
pp. 1457-1468
Author(s):  
Michelle X.G. Pereira ◽  
Amanda S.O. Hammes ◽  
Flavia C. Vasconcelos ◽  
Aline R. Pozzo ◽  
Thaís H. Pereira ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Acute Myeloid Leukemia ◽  
Cell Lines ◽  
Myeloid Leukemia ◽  
Natural Compound ◽  
Dna Topoisomerases ◽  
Human Dna ◽  
Pomolic Acid ◽  
Acute Myeloid

Background: Acute myeloid leukemia (AML) represents the largest number of annual deaths from hematologic malignancy. In the United States, it was estimated that 21.380 individuals would be diagnosed with AML and 49.5% of patients would die in 2017. Therefore, the search for novel compounds capable of increasing the overall survival rate to the treatment of AML cells is urgent. Objectives: To investigate the cytotoxicity effect of the natural compound pomolic acid (PA) and to explore the mechanism of action of PA in AML cell lines with different phenotypes. Methods: Three different AML cell lines, HL60, U937 and Kasumi-1 cells with different mechanisms of resistance were used to analyze the effect of PA on the cell cycle progression, on DNA intercalation and on human DNA topoisomerases (hTopo I and IIα) in vitro studies. Theoretical experiments of the inhibition of hTopo I and IIα were done to explore the binding modes of PA. Results: PA reduced cell viability, induced cell death, increased sub-G0/G1 accumulation and activated caspases pathway in all cell lines, altered the cell cycle distribution and inhibited the catalytic activity of both human DNA topoisomerases. Conclusion: Finally, this study showed that PA has powerful antitumor activity against AML cells, suggesting that this natural compound might be a potent antineoplastic agent to improve the treatment scheme of this neoplasm.

Domain Mapping of the DNA Binding, Endonuclease, and ERCC1 Binding Properties of the Human DNA Repair Protein XPF†

Biochemistry ◽  
1999 ◽  
Vol 38 (29) ◽  
pp. 9417-9425 ◽  
Author(s):  
Sandra L. McCutchen-Maloney ◽  
Cindi A. Giannecchini ◽  
Mona H. Hwang ◽  
Michael P. Thelen
Keyword(s):  
Dna Repair ◽  
Dna Binding ◽  
Binding Properties ◽  
Human Dna ◽  
Repair Protein ◽  
Domain Mapping ◽  
Dna Repair Protein

Anthocyanidins Modulate the Activity of Human DNA Topoisomerases I and II and Affect Cellular DNA Integrity

2005 ◽  
Vol 18 (9) ◽  
pp. 1395-1404 ◽  
Author(s):  
Michael Habermeyer ◽  
Jessica Fritz ◽  
Hans U. Barthelmes ◽  
Morten O. Christensen ◽  
Morten K. Larsen ◽  
...  
Keyword(s):  
Dna Integrity ◽  
Dna Topoisomerases ◽  
Human Dna ◽  
Cellular Dna

Unravelling the Function of Human DNA-Binding Protein Par14 in the Cellular Nucleus

2008 ◽  
Vol 2008 (Spring) ◽  
Author(s):  
Akuma Divine Saningong ◽  
Peter Bayer ◽  
Jonathan Wolf Mueller
Keyword(s):  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Human Dna

scholarly journals DNA binding properties of human DNA polymerase η: implications for fidelity and polymerase switching of translesion synthesis

2004 ◽  
Vol 9 (12) ◽  
pp. 1139-1150 ◽  
Author(s):  
Rika Kusumoto ◽  
Chikahide Masutani ◽  
Shizu Shimmyo ◽  
Shigenori Iwai ◽  
Fumio Hanaoka
Keyword(s):  
Dna Binding ◽  
Dna Polymerase ◽  
Translesion Synthesis ◽  
Binding Properties ◽  
Human Dna ◽  
Dna Binding Properties

Corrigendum to “Non-specific DNA binding interferes with the efficient excision of oxidative lesions from chromatin by the human DNA glycosylase, NEIL1” [DNA Repair 9 (2010) 134–143]

DNA Repair ◽  
2010 ◽  
Vol 9 (8) ◽  
pp. 938 ◽  
Author(s):  
Ian D. Odell ◽  
Kheng Newick ◽  
Nicholas H. Heintz ◽  
Susan S. Wallace ◽  
David S. Pederson
Keyword(s):  
Dna Repair ◽  
Dna Binding ◽  
Dna Glycosylase ◽  
Human Dna

The Topopyrones Poison Human DNA Topoisomerases I and II

2008 ◽  
Vol 130 (39) ◽  
pp. 12888-12889 ◽  
Author(s):  
Qasim A. Khan ◽  
Mark A. Elban ◽  
Sidney M. Hecht
Keyword(s):  
Dna Topoisomerases ◽  
Human Dna
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