Diastereomeric DNA-Binding Geometries of Intercalated Ruthenium(II) Trischelates Probed by Linear Dichroism:  [Ru(phen)2DPPZ]2+and [Ru(phen)2BDPPZ]2+

1996 ◽  
Vol 118 (11) ◽  
pp. 2644-2653 ◽  
Author(s):  
Per Lincoln ◽  
Anders Broo ◽  
Bengt Nordén
Keyword(s):  
Dna Binding ◽  
Linear Dichroism

DNA Binding by Fagaronine and Ethoxidine, Inhibitors of Human DNA Topoisomerases I and II, Probed by SERS and Flow Linear Dichroism Spectroscopy†

1999 ◽  
Vol 103 (11) ◽  
pp. 2008-2013 ◽  
Author(s):  
Anatoli Ianoul ◽  
Fabrice Fleury ◽  
Olivier Duval ◽  
Roger Waigh ◽  
Jean-Claude Jardillier ◽  
...  
Keyword(s):  
Dna Binding ◽  
Linear Dichroism ◽  
Dna Topoisomerases ◽  
Human Dna

Mode of DNA Binding of Bis-Benzimidazoles and Related Structures Studied by Electric Linear Dichroism

1994 ◽  
Vol 12 (1) ◽  
pp. 173-181 ◽  
Author(s):  
Christian Bailly ◽  
Pierre Colson ◽  
Claude Houssier ◽  
Huying Wang ◽  
Yadagiri Bathini ◽  
...  
Keyword(s):  
Dna Binding ◽  
Linear Dichroism

scholarly journals Unspecific DNA binding of the DNA binding domain of the glucocorticoid receptor studied with flow linear dichroism

FEBS Letters ◽  
1989 ◽  
Vol 253 (1-2) ◽  
pp. 28-32 ◽  
Author(s):  
Per Hagmar ◽  
Karin Dahlman ◽  
Masayuki Takahashi ◽  
Jan Carlstedt-Duke ◽  
Jan-Åke Gustafsson ◽  
...  
Keyword(s):  
Dna Binding ◽  
Glucocorticoid Receptor ◽  
Linear Dichroism ◽  
Binding Domain ◽  
Dna Binding Domain

DNA Binding of ∧-and Δ-cis-β-[Ru(RR-picchxn)(phen)]2+Studied by NMR and Flow Linear Dichroism Spectroscopy

1999 ◽  
Vol 17 (3) ◽  
pp. 519-525 ◽  
Author(s):  
Kymberley Vickery ◽  
Robert Vagg ◽  
Per Lincoln ◽  
Bengt Nordén ◽  
Magdalena Eriksson
Keyword(s):  
Dna Binding ◽  
Linear Dichroism

scholarly journals Synthesis and DNA-Binding Studies of a Dinuclear Gadolinium(III)–Platinum(II) Complex

2015 ◽  
Vol 68 (4) ◽  
pp. 576 ◽  
Author(s):  
Jacob M. Fenton ◽  
Madleen Busse ◽  
Louis M. Rendina
Keyword(s):  
Dna Binding ◽  
Linear Dichroism ◽  
Binding Mode ◽  
In Vitro Cytotoxicity ◽  
Binding Studies ◽  
Binding Interaction ◽  
Absorption Region ◽  
Synthetic Strategy ◽  
Dna Binding Studies

The synthesis and characterisation of a new dinuclear GdIII–PtII complex (1·PF6) containing a functionalised macrocyclic 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid derivative linked to a PtII-terpy (terpy = 2,2′ : 6′,2″-terpyridine) unit by means of a short thiolato linker are reported. The complex was synthesised in six steps from cyclen by means of a modular synthetic strategy. A preliminary DNA-binding study with calf-thymus DNA (ct-DNA) was performed on 1·PF6 by means of linear dichroism (LD). The observed changes in the DNA LD signal in the presence of the metal complex are fully consistent with an intercalative binding mode. Furthermore, an induced negative LD signal in the ultraviolet absorption region of the complex provides strong evidence of a strong DNA-binding interaction. The in vitro cytotoxicity of 1·PF6 towards a human glioblastoma cell line (T98G) was also determined.

Water soluble palladium(ii) and platinum(ii) acyclic diaminocarbene complexes: solution behavior, DNA binding, and antiproliferative activity

2020 ◽  
Vol 44 (15) ◽  
pp. 5762-5773 ◽  
Author(s):  
Tatiyana V. Serebryanskaya ◽  
Mikhail A. Kinzhalov ◽  
Vladimir Bakulev ◽  
Georgii Alekseev ◽  
Anastasiya Andreeva ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antiproliferative Activity ◽  
Water Soluble ◽  
Solution Behavior ◽  
Antitumor Potential ◽  
Acyclic Diaminocarbene

Water soluble Pd(ii) and Pt(ii)–ADC species synthesized via the metal-mediated coupling of isocyanides and 1,2-diaminobenzene have demonstrated antitumor potential.

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