Modeling Enzyme Reaction Intermediates and Transition States:  Citrate Synthase

1998 ◽  
Vol 102 (34) ◽  
pp. 6635-6646 ◽  
Author(s):  
Adrian J. Mulholland ◽  
W. Graham Richards
Keyword(s):  
Citrate Synthase ◽  
Transition States ◽  
Enzyme Reaction ◽  
Reaction Intermediates

The Role of the Substituent Pattern in Determining Selectivity in the Preparation of Tricarbonyl(η5-cyclohexadienyl)iron(1+) Salts by Acid-Catalyzed Demethoxylation

1992 ◽  
Vol 45 (1) ◽  
pp. 121 ◽  
Author(s):  
GR Stephenson ◽  
DA Owen ◽  
H Finch ◽  
S Swanson
Keyword(s):  
Transition States ◽  
Kinetic Control ◽  
Reaction Intermediates ◽  
Acid Catalyzed

The factors that determine the selectivity of the acid-catalysed dealkoxylation of unsymmetrically substituted tricarbonyl(η4-alkoxycyclohexa-1,3-diene)iron(0) complexes have been investigated. Regioselective demethoxylation of complexes with a variety of substitution patterns has indicated that the selectivity arises from differences in the stabilization of the reaction intermediates and transition states by the diene substituents on the π-bound ligand. The observed regioisomers correspond to the product of the most stabilized intermediate pathway, rather than the product of minimum rearrangement. The reactions have been shown to proceed under kinetic control.

Synthesis of Novel Analogs of Acetyl Coenzyme A: Mimics of Enzyme Reaction Intermediates

1994 ◽  
Vol 116 (11) ◽  
pp. 4660-4668 ◽  
Author(s):  
David P. Martin ◽  
Richard T. Bibart ◽  
Dale G. Drueckhammer
Keyword(s):  
Coenzyme A ◽  
Enzyme Reaction ◽  
Reaction Intermediates ◽  
Acetyl Coenzyme A ◽  
Acetyl Coenzyme

Detection of Acetyl-S-Enzyme Reaction Intermediates of Hydroxymethylglutaryl-CoA Synthase and β-Ketothiolase by13C NMR

1999 ◽  
Vol 121 (1) ◽  
pp. 270-271 ◽  
Author(s):  
Dmitriy Vinarov ◽  
Chakravarthy Narasimhan ◽  
Henry M. Miziorko
Keyword(s):  
Enzyme Reaction ◽  
Reaction Intermediates

Effect of Solvation on Ozonolysis Reaction Intermediates and Transition States

2000 ◽  
Vol 6 (12) ◽  
pp. 608-617 ◽  
Author(s):  
Cenk Selçuki ◽  
Viktorya Aviyente ◽  
Philippe Aplincourt ◽  
Manuel Felipe Ruiz-López
Keyword(s):  
Transition States ◽  
Reaction Intermediates
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