Crystal Plane- and Size-Dependent Protein Adsorption on Nanozeolite

2009 ◽  
Vol 113 (42) ◽  
pp. 18040-18046 ◽  
Author(s):  
Yuan-Yuan Hu ◽  
Ya-Hong Zhang ◽  
Nan Ren ◽  
Yi Tang
Keyword(s):  
Protein Adsorption ◽  
Crystal Plane ◽  
Size Dependent ◽  
Dependent Protein

scholarly journals Size-dependent protein segregation at membrane interfaces

2016 ◽  
Vol 12 (7) ◽  
pp. 704-711 ◽  
Author(s):  
Eva M. Schmid ◽  
Matthew H. Bakalar ◽  
Kaushik Choudhuri ◽  
Julian Weichsel ◽  
Hyoung Sook Ann ◽  
...  
Keyword(s):  
Size Dependent ◽  
Membrane Interfaces ◽  
Dependent Protein

scholarly journals Microscopic Investigation of Reversible Nanoscale Surface Size Dependent Protein Conjugation

2009 ◽  
Vol 10 (5) ◽  
pp. 2348-2366 ◽  
Author(s):  
Kazushige Yokoyama ◽  
Hyunah Cho ◽  
Sean Cullen ◽  
Matthew Kowalik ◽  
Nicole Briglio ◽  
...  
Keyword(s):  
Microscopic Investigation ◽  
Protein Conjugation ◽  
Size Dependent ◽  
Dependent Protein

scholarly journals Mechanisms for Size-Dependent Protein Segregation at Immune Synapses Assessed with Molecular Rulers

2011 ◽  
Vol 100 (12) ◽  
pp. 2865-2874 ◽  
Author(s):  
Juha-Matti Alakoskela ◽  
Apurba L. Koner ◽  
Dominika Rudnicka ◽  
Karsten Köhler ◽  
Mark Howarth ◽  
...  
Keyword(s):  
Size Dependent ◽  
Molecular Rulers ◽  
Immune Synapses ◽  
Dependent Protein

scholarly journals Indirect Nanoplasmonic Sensing Platform for Monitoring Temperature-Dependent Protein Adsorption

2017 ◽  
Vol 89 (23) ◽  
pp. 12976-12983 ◽  
Author(s):  
Joshua A. Jackman ◽  
Abdul Rahim Ferhan ◽  
Bo Kyeong Yoon ◽  
Jae Hyeon Park ◽  
Vladimir P. Zhdanov ◽  
...  
Keyword(s):  
Protein Adsorption ◽  
Temperature Dependent ◽  
Sensing Platform ◽  
Dependent Protein ◽  
Monitoring Temperature

Titania nanotubes dimensions-dependent protein adsorption and its effect on the growth of osteoblasts

2013 ◽  
Vol 102 (10) ◽  
pp. 3598-3608 ◽  
Author(s):  
Weihu Yang ◽  
Xingfeng Xi ◽  
Xinkun Shen ◽  
Peng Liu ◽  
Yan Hu ◽  
...  
Keyword(s):  
Protein Adsorption ◽  
Titania Nanotubes ◽  
Dependent Protein

scholarly journals Size-dependent protein segregation creates a spatial switch for Notch and APP signaling

2020 ◽  
Author(s):  
Minsuk Kwak ◽  
Kaden M. Southard ◽  
Nam Hyeong Kim ◽  
Ramu Gopalappa ◽  
Woon Ryoung Kim ◽  
...  
Keyword(s):  
Cell Surface ◽  
Amyloid Precursor Proteins ◽  
High Cell ◽  
Downstream Signaling ◽  
Size Dependent ◽  
Enzyme Substrate ◽  
Secretase Activity ◽  
Precursor Proteins ◽  
Dependent Protein ◽  
Dependent Mechanism

Aberrant cleavage of Notch and amyloid precursor proteins (APPs) by γ-secretase is implicated in numerous diseases, but how cleavage is regulated in space and time is unclear. Here, we report that cadherin-based adherens junctions (cadAJs) are sites of high cell-surface γ-secretase activity, while simultaneously excluding these γ-secretase substrates by a size-dependent mechanism, prohibiting enzyme-substrate interactions. Upon activation, Notch and APP undergo drastic spatial rearrangements to cadAJs, concentrating them with γ-secretase, wherein they are further processed for downstream signaling. Spatial mutation by decreasing (or increasing) the size of Notch extracellular domain promotes (or inhibits) signaling, respectively. Dysregulation of this spatial switch also promotes formation of more amyloidogenic Aβ. Therefore, cadAJs creates distinct biochemical compartments regulating signaling events involving γ-secretase and prevent pathogenic activation of its substrates.

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